WormBase Tree Display for Gene: WBGene00000767
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| WBGene00000767 | Evidence | Paper_evidence | WBPaper00013270 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C35D10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | coq-8 | Person_evidence | WBPerson247 | |||||
| Sequence_name | C35D10.4 | ||||||||
| Molecular_name | C35D10.4 | ||||||||
| C35D10.4.1 | |||||||||
| CE32159 | |||||||||
| Other_name | CELE_C35D10.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | coq-8 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | coq | ||||||||
| Allele (41) | |||||||||
| Strain | WBStrain00035920 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00061363 | ||||||||
| 00061364 | |||||||||
| 00061365 | |||||||||
| 00061366 | |||||||||
| 00061367 | |||||||||
| 00061368 | |||||||||
| 00061369 | |||||||||
| 00061370 | |||||||||
| 00061371 | |||||||||
| Contained_in_operon | CEOP3226 | ||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00007358 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00008410 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010877 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010897 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00014164 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016355 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018523 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021315 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | coq-8 encodes a putative protein kinase orthologous to ABC1 (COQ8) fromS. cerevisiae and UbiB from E. coli, and paralogous to C. elegansD2023.6 and its (uncharacterized) eukaryotic orthologs; COQ-8 isrequired for ubiquinone (coenzyme Q9) biosynthesis and for normallyshort lifespan; alternative hypotheses for COQ-8's biochemical functionare that it is a 2-polyprenylphenol 6-hydroxylase, or that it mayactivate proteins necessary for monooxygenase activity viaphosphorylation; coq-8 is expressed in several tissues during larvaldevelopment, but in later adult life its expression is restricted toneurons; coq-8 mutants have slowed pharyngeal pumping, and eventuallyarrest as paralysed larvae before dying; coq-8(RNAi) animals havereduced levels of coenzyme Q9 and superoxide, and have abnormally longlifespans; coq-8 mutants are not rescued by dietary coenzyme Q. | Paper_evidence | WBPaper00005863 | |||||
| WBPaper00013530 | |||||||||
| WBPaper00013607 | |||||||||
| WBPaper00027036 | |||||||||
| WBPaper00028290 | |||||||||
| WBPaper00028292 | |||||||||
| WBPaper00028324 | |||||||||
| WBPaper00028325 | |||||||||
| WBPaper00028394 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Oct 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity and transferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Expressed in coelomocyte; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9 and primary coenzyme Q10 deficiency 4. Is an ortholog of human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070241 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16812) | ||||
| DOID:0080391 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19041) | ||||||
| Molecular_info | Corresponding_CDS | C35D10.4 | |||||||
| Corresponding_CDS_history | C35D10.4:wp88 | ||||||||
| Corresponding_transcript | C35D10.4.1 | ||||||||
| Other_sequence (51) | |||||||||
| Associated_feature | WBsf658874 | ||||||||
| WBsf992233 | |||||||||
| WBsf1014813 | |||||||||
| WBsf224816 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00041986 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00011663 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041985 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001233 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022977 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027211 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029580 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024743 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005952 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3875 | ||||||||
| Expr1017796 | |||||||||
| Expr1030472 | |||||||||
| Expr1145996 | |||||||||
| Expr2010467 | |||||||||
| Expr2028707 | |||||||||
| Drives_construct | WBCnstr00011708 | ||||||||
| WBCnstr00037292 | |||||||||
| Construct_product | WBCnstr00011708 | ||||||||
| WBCnstr00037292 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (65) | |||||||||
| Map_info | Map | III | Position | -2.41526 | Error | 0.000858 | |||
| Positive | Positive_clone | C35D10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
