WormBase Tree Display for Gene: WBGene00000767
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WBGene00000767 | Evidence | Paper_evidence | WBPaper00013270 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C35D10 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | coq | ||||||
Allele (41) | |||||||
Strain | WBStrain00035920 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00061363 | ||||||
00061364 | |||||||
00061365 | |||||||
00061366 | |||||||
00061367 | |||||||
00061368 | |||||||
00061369 | |||||||
00061370 | |||||||
00061371 | |||||||
Contained_in_operon | CEOP3226 | ||||||
Ortholog (44) | |||||||
Paralog | WBGene00007358 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00008410 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00010877 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00010897 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00014164 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00016355 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00018523 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00021315 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | coq-8 encodes a putative protein kinase orthologous to ABC1 (COQ8) fromS. cerevisiae and UbiB from E. coli, and paralogous to C. elegansD2023.6 and its (uncharacterized) eukaryotic orthologs; COQ-8 isrequired for ubiquinone (coenzyme Q9) biosynthesis and for normallyshort lifespan; alternative hypotheses for COQ-8's biochemical functionare that it is a 2-polyprenylphenol 6-hydroxylase, or that it mayactivate proteins necessary for monooxygenase activity viaphosphorylation; coq-8 is expressed in several tissues during larvaldevelopment, but in later adult life its expression is restricted toneurons; coq-8 mutants have slowed pharyngeal pumping, and eventuallyarrest as paralysed larvae before dying; coq-8(RNAi) animals havereduced levels of coenzyme Q9 and superoxide, and have abnormally longlifespans; coq-8 mutants are not rescued by dietary coenzyme Q. | Paper_evidence | WBPaper00005863 | |||
WBPaper00013530 | |||||||
WBPaper00013607 | |||||||
WBPaper00027036 | |||||||
WBPaper00028290 | |||||||
WBPaper00028292 | |||||||
WBPaper00028324 | |||||||
WBPaper00028325 | |||||||
WBPaper00028394 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 26 Oct 2006 00:00:00 | ||||||
Automated_description | Predicted to enable ATP binding activity and transferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Expressed in coelomocyte; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9 and primary coenzyme Q10 deficiency 4. Is an ortholog of human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0070241 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16812) | ||
DOID:0080391 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19041) | ||||
Molecular_info | Corresponding_CDS | C35D10.4 | |||||
Corresponding_CDS_history | C35D10.4:wp88 | ||||||
Corresponding_transcript | C35D10.4.1 | ||||||
Other_sequence (51) | |||||||
Associated_feature | WBsf658874 | ||||||
WBsf992233 | |||||||
WBsf1014813 | |||||||
WBsf224816 | |||||||
Experimental_info | RNAi_result | WBRNAi00041986 | Inferred_automatically | RNAi_primary | |||
WBRNAi00011663 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041985 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001233 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022977 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027211 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00029580 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00024743 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005952 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr3875 | ||||||
Expr1017796 | |||||||
Expr1030472 | |||||||
Expr1145996 | |||||||
Expr2010467 | |||||||
Expr2028707 | |||||||
Drives_construct | WBCnstr00011708 | ||||||
WBCnstr00037292 | |||||||
Construct_product | WBCnstr00011708 | ||||||
WBCnstr00037292 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (119) | |||||||
Interaction (65) | |||||||
Map_info | Map | III | Position | -2.41526 | Error | 0.000858 | |
Positive | Positive_clone | C35D10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (16) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |