coq-8 encodes a putative protein kinase orthologous to ABC1 (COQ8) fromS. cerevisiae and UbiB from E. coli, and paralogous to C. elegansD2023.6 and its (uncharacterized) eukaryotic orthologs; COQ-8 isrequired for ubiquinone (coenzyme Q9) biosynthesis and for normallyshort lifespan; alternative hypotheses for COQ-8's biochemical functionare that it is a 2-polyprenylphenol 6-hydroxylase, or that it mayactivate proteins necessary for monooxygenase activity viaphosphorylation; coq-8 is expressed in several tissues during larvaldevelopment, but in later adult life its expression is restricted toneurons; coq-8 mutants have slowed pharyngeal pumping, and eventuallyarrest as paralysed larvae before dying; coq-8(RNAi) animals havereduced levels of coenzyme Q9 and superoxide, and have abnormally longlifespans; coq-8 mutants are not rescued by dietary coenzyme Q.
Predicted to enable ATP binding activity and transferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Expressed in coelomocyte; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9 and primary coenzyme Q10 deficiency 4. Is an ortholog of human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.