WormBase Tree Display for Gene: WBGene00000526

WBGene00000526 Evidence: Person_evidence: WBPerson765
  SMap: S_parent: Sequence: C01C10
  Identity: Version: 1
    Name: CGC_name: clc-5
      Sequence_name: C01C10.4
      Molecular_name: C01C10.4
        C01C10.4.1
        CE28882
      Other_name: CELE_C01C10.4 Accession_evidence: NDB BX284606
      Public_name: clc-5
    DB_info: Database: AceView gene XI53
        WormQTL gene WBGene00000526
        WormFlux gene WBGene00000526
        NDB locus_tag CELE_C01C10.4
        Panther gene CAEEL|WormBase=WBGene00000526|UniProtKB=Q9NGJ7
          family PTHR10671
        NCBI gene 181000
        RefSeq protein NM_076857.7
        SwissProt UniProtAcc Q9NGJ7
        TREEFAM TREEFAM_ID TF316179
        UniProt_GCRP UniProtAcc Q9NGJ7
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clc
    Allele (47)
    Strain: WBStrain00051462
    RNASeq_FPKM (74)
    GO_annotation: 00096673
      00096674
      00096675
      00096676
      00096677
      00096678
      00107535
    Contained_in_operon: CEOPX088
    Ortholog (27)
    Paralog: WBGene00000522 Caenorhabditis elegans From_analysis: Panther
      WBGene00000523 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00013458
      WBGene00011014 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00016067 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00010742 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00016706 Caenorhabditis elegans From_analysis: Panther
      WBGene00021415 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: clc-5 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; CLC-5 is worm-specific, with obvious homologs only in C. elegans; CLC-5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. Paper_evidence: WBPaper00004961
            WBPaper00005654
            WBPaper00005946
            WBPaper00005975
            WBPaper00012856
            WBPaper00018356
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be located in plasma membrane. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C01C10.4
    Corresponding_transcript: C01C10.4.1
    Other_sequence (17)
    Associated_feature: WBsf662967
      WBsf235934
  Experimental_info: RNAi_result: WBRNAi00009908 Inferred_automatically: RNAi_primary
      WBRNAi00039293 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1022861
      Expr1030313
      Expr1143411
      Expr2010045
      Expr2028286
    Drives_construct: WBCnstr00037473
    Construct_product: WBCnstr00037473
    Microarray_results (20)
    Expression_cluster: WBPaper00032976:dosage_compensated_genes
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040560:hpl-2_embryo_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046121:ecdoderm_unique
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AMsh
      WBPaper00061340:B_F_K_Kp_U_Y
      WBPaper00061340:CEPsh
      WBPaper00061340:CEPso
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:F_U
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:Glia
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:hyp3
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:ILso
      WBPaper00061340:P_cell
      WBPaper00061340:Tail_hypodermis
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:lon-8-C18D11.1_11630
      WBPaper00061651:AMso_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
      WBPaper00065841:5_0
      WBPaper00065841:5_1
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4489_group_14
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00034739:N2lessDR1350
      WBPaper00035227:heat_shock_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_A
    Interaction: WBInteraction000579893
  Map_info: Map: X Position: -1.72843
    Positive: Positive_clone: C01C10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00039831
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene