| WBGene00000469 | SMap | S_parent | Sequence | ZK909 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | ces-2 | Person_evidence | WBPerson268 |
| | | Sequence_name | ZK909.4 |
| | | Molecular_name | ZK909.4 |
| | | | ZK909.4.1 |
| | | | CE15479 |
| | | Other_name | CELE_ZK909.4 | Accession_evidence | NDB | BX284601 |
| | | Public_name | ces-2 |
| | DB_info | Database | AceView | gene | 1P559 |
| | | | WormQTL | gene | WBGene00000469 |
| | | | WormFlux | gene | WBGene00000469 |
| | | | NDB | locus_tag | CELE_ZK909.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000469|UniProtKB=Q94126 |
| | | | | family | PTHR11988 |
| | | | NCBI | gene | 173365 |
| | | | RefSeq | protein | NM_061209.6 |
| | | | SwissProt | UniProtAcc | Q94126 |
| | | | TREEFAM | TREEFAM_ID | TF315869 |
| | | | UniProt_GCRP | UniProtAcc | Q94126 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ces |
| | Allele (73) |
| | Legacy_information | [C.elegansII] n732 : sisters of NSM (but not I2) fail to undergo programmed cell death.Cloned: encodes protein related to bZIP transcription factors.[Ellis and Horvitz 1991; MT] |
| | | [C.elegansII] n732 : sisters of NSM (but not I2) fail to undergo programmed cell death. Cloned: encodes protein related to bZIP transcription factors. [Ellis and Horvitz 1991; MT] |
| | Strain | WBStrain00027189 |
| | | WBStrain00036792 |
| | | WBStrain00036925 |
| | | WBStrain00051976 |
| | | WBStrain00055552 |
| | RNASeq_FPKM (74) |
| | GO_annotation (31) |
| | Ortholog (51) |
| | Paralog | WBGene00000220 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | WBGene00017535 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00013100 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00011130 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor, most similar in sequence and binding specificity to the PAR (proline- and acid-rich) subfamily of bZIP proteins; ces-2 is required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons, and is transcriptionally inhibited by activated LET-60(G12V); in regulating programmed cell death in the NSM sister cell, CES-2 functions together with DNJ-11 to negatively regulate transcription of ces-1 which, in turn, negatively regulates transcription of the pro-apoptotic BH3-only gene egl-1; ces-2 also functions together with dnj-11 to regulate asymmetric cell division and mitotic spindle orientation in the NSM lineage, revealing a functional coupling between asymmetric cell division and apoptosis. | Paper_evidence | WBPaper00002515 |
| | | | | | WBPaper00005376 |
| | | | | | WBPaper00031670 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 15 Dec 2008 00:00:00 |
| | | Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including apoptotic process; positive regulation of programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in excretory duct cell. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in osteoporosis and stomach cancer. Is an ortholog of human DBP (D-box binding PAR bZIP transcription factor); HLF (HLF transcription factor, PAR bZIP family member); and TEF (TEF transcription factor, PAR bZIP family member). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:9952 | Homo sapiens | Paper_evidence | WBPaper00002515 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 26 Oct 2018 00:00:00 |
| | Potential_model | DOID:11476 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2697) |
| | | DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4977) |
| Models_disease_asserted | WBDOannot00000241 |
| Molecular_info | Corresponding_CDS | ZK909.4 |
| | Corresponding_transcript | ZK909.4.1 |
| | Other_sequence | CRC07313_1 |
| | | Dviv_isotig25154 |
| | | JI177917.1 |
| | | CR05555 |
| | | JI167952.1 |
| | | GO250055.1 |
| | | JI169216.1 |
| | Associated_feature | WBsf655757 |
| | | WBsf657146 |
| | | WBsf657147 |
| | | WBsf657148 |
| | | WBsf978677 |
| | | WBsf986281 |
| | | WBsf986282 |
| | | WBsf1011319 |
| | | WBsf1011320 |
| | | WBsf218845 |
| | Gene_product_binds | WBsf019095 |
| | | WBsf019096 |
| | | WBsf019219 |
| | Transcription_factor | WBTranscriptionFactor000051 |
| Experimental_info | RNAi_result | WBRNAi00027823 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00095100 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00113960 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115662 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059827 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00004955 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00095099 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00107244 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116606 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr2959 |
| | | Expr10532 |
| | | Expr1020106 |
| | | Expr1030273 |
| | | Expr1163256 |
| | | Expr2009927 |
| | | Expr2028167 |
| | Drives_construct | WBCnstr00011044 |
| | | WBCnstr00015519 |
| | | WBCnstr00018613 |
| | | WBCnstr00037513 |
| | Construct_product | WBCnstr00015519 |
| | | WBCnstr00021934 |
| | | WBCnstr00037513 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00024505:pharyngeal_enriched |
| | | WBPaper00027339:daf-12(rh273)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00042561:smgl-1(RNAi)_downregulated |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045809:rsd-2(yp10)_downregulated |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00048690:male-Z1-Z4-daughter_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_4 |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049954:BPS_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051265:F1_hrde-1(tm1200)_downregulated |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00051388:Glucose-diet_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053771:up_at_3h-NaCl |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Metformin_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055386:eat-2(ad465)_downregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055827:pfd-6(gk493446)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056330:glycine_upregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058948:npr-8(ok1439)_upregulated_OP50 |
| | | WBPaper00058948:npr-8(ok1439)_upregulated_PA14 |
| | | WBPaper00058955:heatshock_upregulated_CE |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059117:B.subtilis_downregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059605:mut-16(pk710)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00059735:glucose_upregulated_N2 |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060526:plp-1(ok2155)_downregulated |
| | | WBPaper00060764:swsn-1(os22ts)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:AMso_parent |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:mc3 |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061340:Parents_of_U_F_B_DVA |
| | | WBPaper00061340:Parents_of_Y_DA6_DA7_DA9 |
| | | WBPaper00061340:Parent_of_AMsh_URB |
| | | WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3 |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061340:Parent_of_K_Kprime |
| | | WBPaper00061340:Pharyngeal_marginal_cell |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RME_LR_parent |
| | | WBPaper00061340:URA_parent |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:F58E6.13_17427-ifa-3 |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061952:daf-18(yh1)_downregulated |
| | | WBPaper00062146:MOG-7-degron_2h_regulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062184:PA14_downregulated |
| | | WBPaper00062344:grh-1(overexpression)_upregulated |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062456:doxycycline_downregulated_N2_transcript |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062587:lsl-1(ljm1)_downregulated |
| | | WBPaper00062587:lsl-1(tm4769)_downregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064509:static-magnetic-field_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065005:sams-3(RNAi)_upregulated |
| | | WBPaper00065005:sams-4(RNAi)_upregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065392:Lb.gasseri_downregulated |
| | | WBPaper00065392:P.pentosaceus_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day5 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_OP50 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066005:RAGA-1_degradation_somatic_upregulated |
| | | WBPaper00066093:E.coli-purE_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00066204:CdCl2_downregulated_mRNA |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_WT |
| | | cgc4386_cluster_6_2 |
| | | cgc4489_group_9 |
| | | WBPaper00013489:Ray_Enriched |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00027111:rrf-2(ok210)_upregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00039866:ClassComp_daf-19_upregulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041002:HF_11d_0.2mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00042258:DA1877_downregulated_GravidAdult |
| | | WBPaper00046639:tyrosol_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5376]:let-60(G12V)-regulated_genes |
| | | [cgc6390]:Cluster_E |
| | Interaction (293) |
| Map_info | Map | I | Position | 28.8514 | Error | 0.014285 |
| | Well_ordered |
| | Positive | Positive_clone | C01F5 |
| | | | ZK909 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 1238 |
| | | | 1239 |
| | | | 4455 |
| | | Pos_neg_data | 3215 |
| | | | 3216 |
| | | | 3217 |
| | | | 3218 |
| | | | 3219 |
| | | | 3739 |
| | | | 3740 |
| | | | 3741 |
| | | | 3742 |
| Reference (76) |
| Method | Gene |
