WormBase Tree Display for Gene: WBGene00000220
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| WBGene00000220 | SMap | S_parent | Sequence | K08F8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | atf-2 | Person_evidence | WBPerson531 | |||||
| Sequence_name | K08F8.2 | ||||||||
| Molecular_name | K08F8.2 | ||||||||
| K08F8.2.1 | |||||||||
| CE03468 | |||||||||
| Other_name | CELE_K08F8.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | atf-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | atf | ||||||||
| Allele (28) | |||||||||
| Strain | WBStrain00051944 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00000469 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00017535 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Structured_description | Concise_description | atf-2 encodes a cAMP-dependent transcription factor paralogous to CES-2, a bZip-like transcription factor that plays a key role in regulation of apoptosis; atf-2 activity is required for excretory duct cell development and essential for embryonic development; in regulating excretory duct cell development, ATF-2 controls expression of lin-48; in vitro, ATF-2 binds the regulatory regions of LIN-48 and the autophagy genes BEC-1, and LGG-1; loss of atf-2 activity results in increased LGG-1 and BEC-1 expression, suggesting that ATF-2 negatively regulates lgg-1 and bec-1 expression in vivo; ATF-2 and CES-2 can physically interact in vivo; atf-2 is broadly expressed in embryos, and is also seen in larvae and adults. | Paper_evidence | WBPaper00041324 | |||||
| WBPaper00038332 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Jul 2012 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and protein heterodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in digestive tract; egg-laying apparatus; excretory system; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in severe acute respiratory syndrome. Is an ortholog of human NFIL3 (nuclear factor, interleukin 3 regulated) and NFILZ (NFIL3 like basic leucine zipper). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2945 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7787) | ||||
| Molecular_info | Corresponding_CDS | K08F8.2 | |||||||
| Corresponding_transcript | K08F8.2.1 | ||||||||
| Other_sequence | TSC14388_1 | ||||||||
| Dviv_isotig14055 | |||||||||
| ES570489.1 | |||||||||
| Dviv_isotig14056 | |||||||||
| JI168348.1 | |||||||||
| CJC10881_1 | |||||||||
| JI474868.1 | |||||||||
| Tcir_isotig07550 | |||||||||
| Associated_feature (12) | |||||||||
| Transcription_factor | WBTranscriptionFactor000652 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00016836 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001026 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115777 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102544 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050328 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034155 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102545 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102538 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr7612 | ||||||||
| Expr10531 | |||||||||
| Expr1017113 | |||||||||
| Expr1030137 | |||||||||
| Expr1154030 | |||||||||
| Expr2009479 | |||||||||
| Expr2027716 | |||||||||
| Drives_construct | WBCnstr00008244 | ||||||||
| WBCnstr00012757 | |||||||||
| WBCnstr00015518 | |||||||||
| WBCnstr00037652 | |||||||||
| Construct_product | WBCnstr00015518 | ||||||||
| WBCnstr00017972 | |||||||||
| WBCnstr00037652 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (270) | |||||||||
| Interaction (172) | |||||||||
| Map_info | Map | II | Position | 0.874865 | Error | 0.001605 | |||
| Positive | Positive_clone | K08F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4328 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
