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WormBase Tree Display for Gene: WBGene00000450

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Name Class

WBGene00000450SMapS_parentSequenceK03A11
IdentityVersion1
NameCGC_nameceh-28Person_evidenceWBPerson83
Sequence_nameK03A11.3
Molecular_nameK03A11.3
K03A11.3.1
CE42603
Other_nameCELE_K03A11.3Accession_evidenceNDBBX284606
Public_nameceh-28
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classceh
Allele (27)
StrainWBStrain00002444
WBStrain00001573
WBStrain00029949
WBStrain00032224
WBStrain00052007
RNASeq_FPKM (74)
GO_annotation (24)
Ortholog (29)
ParalogWBGene00000428Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000430Caenorhabditis elegansFrom_analysisTreeFam
WBGene00000434Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000445Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000447Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000449Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000463Caenorhabditis elegansFrom_analysisTreeFam
WBGene00004011Caenorhabditis elegansFrom_analysisTreeFam
WBGene00000584Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionceh-28 encodes a homeodomain protein of the NK-2 family; ceh-28 is expressed in a single pharyngeal neuron, M4; within M4, CEH-28 functions to positively regulate the expression of dbl-1, which encodes a TGF-beta, and hence, TGF-beta signaling to ensure proper morphology of the pharyngeal g1 gland cells that are located adjacent to M4.Paper_evidenceWBPaper00045065
Curator_confirmedWBPerson1843
WBPerson324
Date_last_updated09 Apr 2014 00:00:00
Automated_descriptionEnables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Part of chromatin. Expressed in several structures, including ABalaappa; ABalaappaa; ABalaappap; ABalapapa; and M4 neuron. Human ortholog(s) of this gene implicated in several diseases, including aortic valve disease 2; congenital heart disease (multiple); and heart conduction disease (multiple). Is an ortholog of human NKX2-5 (NK2 homeobox 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (11)
Molecular_infoCorresponding_CDSK03A11.3
Corresponding_CDS_historyK03A11.3:wp101
K03A11.3:wp162
K03A11.3:wp190
Corresponding_transcriptK03A11.3.1
Other_sequenceWBC02282_1
CK854933.1
JI213807.1
Associated_featureWBsf648642
WBsf663461
WBsf978476
Gene_product_bindsWBsf945412
WBsf945413
Transcription_factorWBTranscriptionFactor000466
Experimental_infoRNAi_resultWBRNAi00049786Inferred_automaticallyRNAi_primary
WBRNAi00016509Inferred_automaticallyRNAi_primary
Expr_pattern (13)
Drives_constructWBCnstr00000378
WBCnstr00002413
WBCnstr00004336
WBCnstr00007524
WBCnstr00007530
WBCnstr00012750
WBCnstr00037528
WBCnstr00042411
Construct_productWBCnstr00016730
WBCnstr00037528
WBCnstr00042411
WBCnstr00042628
Microarray_results (19)
Expression_clusterWBPaper00029359_1280
WBPaper00029359_1310
WBPaper00029359_1364
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1578
WBPaper00029359_1604
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032528:L3_depleted
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00061340:ALM_PLM
WBPaper00061340:g1A_g1P
WBPaper00061340:pm1_pm2
WBPaper00061527:sre-33-ZK1025.1_8337
WBPaper00061651:M4_enriched
WBPaper00062103:neuron_enriched
WBPaper00065841:51_1
WBPaper00065841:126_0
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00045673:colistin_upregulated
WBPaper00046548:dafachronic-acid_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
Interaction (33)
Product_binds_matrixWBPmat00005550
Map_infoMapXPosition10.2061Error0.074367
PositivePositive_cloneK03A11Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4372
5332
Pseudo_map_position
Reference (19)
RemarkSequence From Thomas.Burglin@unibas.ch Wed Mar 7 09:49:40 2001
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene