WormBase Tree Display for Gene: WBGene00000584
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| WBGene00000584 | Evidence | Paper_evidence | WBPaper00005610 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | R03C1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cog-1 | Person_evidence | WBPerson625 | |||||
| Sequence_name | R03C1.3 | ||||||||
| Molecular_name | R03C1.3a | ||||||||
| R03C1.3a.1 | |||||||||
| CE25964 | |||||||||
| R03C1.3b | |||||||||
| CE33290 | |||||||||
| R03C1.3b.1 | |||||||||
| Other_name | CELE_R03C1.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | cog-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cog | ||||||||
| Allele (136) | |||||||||
| Legacy_information | cog for Connection of Gonad defective, adults are Egl with abnormal vulval morphology and abnormal connection between uterus and vulva, males are sperm transfer defective with abnormal connection between the vas deferens and the proctodeum | ||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00000428 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000434 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000445 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000447 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000449 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000450 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cog-1 encodes the C. elegans ortholog of the vertebrate Nkx6 homeodomain proteins; cog-1 activity is required for multiple aspects of reproductive system development, including connection of uterus to the vulva and vulval cell specification, as well as for specification of left/right asymmetry in the ASE taste receptor sensory neurons where cog-1 acts in ASER to suppress the ASEL cell fate; cog-1 expression in ASEL is negatively regulated by the lsy-6 miRNA; a cog-1::gfp reporter fusion is expressed in neurons and in the hermaphrodite vulva and uterus; in males, cog-1::gfp expression is seen in proctodeal cells and occasionally in the rectal Rep cells and P11.pp progeny. | Paper_evidence | WBPaper00005610 | |||||
| WBPaper00006052 | |||||||||
| WBPaper00006260 | |||||||||
| WBPaper00031556 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 24 Feb 2009 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor binding activity. Involved in several processes, including determination of left/right symmetry; neuron development involved in amphid sensory organ development; and regulation of gene expression. Predicted to be located in nucleus. Expressed in several structures, including body ganglion; egg-laying apparatus; head neurons; male-specific anatomical entity; and tail ganglion. Human ortholog(s) of this gene implicated in spastic ataxia 8. Is an ortholog of human NKX6-1 (NK6 homeobox 1) and NKX6-2 (NK6 homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080252 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19321) | ||||
| Molecular_info | Corresponding_CDS | R03C1.3a | |||||||
| R03C1.3b | |||||||||
| Corresponding_transcript | R03C1.3a.1 | ||||||||
| R03C1.3b.1 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature (16) | |||||||||
| Transcription_factor | WBTranscriptionFactor000687 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00107689 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001218 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051169 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017345 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062927 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034550 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00004665 | ||||||||
| WBCnstr00004666 | |||||||||
| WBCnstr00004672 | |||||||||
| WBCnstr00006876 | |||||||||
| WBCnstr00006877 | |||||||||
| WBCnstr00014600 | |||||||||
| WBCnstr00017428 | |||||||||
| WBCnstr00023015 | |||||||||
| WBCnstr00037445 | |||||||||
| WBCnstr00042865 | |||||||||
| Construct_product | WBCnstr00006104 | ||||||||
| WBCnstr00006105 | |||||||||
| WBCnstr00007700 | |||||||||
| WBCnstr00016151 | |||||||||
| WBCnstr00017428 | |||||||||
| WBCnstr00021774 | |||||||||
| WBCnstr00037445 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (143) | |||||||||
| Map_info | Map | II | Position | 23.6958 | Error | 0.059369 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | R03C1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Negative_clone | R13D4 | |||||||
| Mapping_data | Multi_point | 3511 | |||||||
| 3512 | |||||||||
| 4085 | |||||||||
| 4193 | |||||||||
| 5524 | |||||||||
| Pos_neg_data | 9070 | ||||||||
| 9071 | |||||||||
| 9072 | |||||||||
| 9073 | |||||||||
| 9074 | |||||||||
| 9075 | |||||||||
| Reference (67) | |||||||||
| Method | Gene |
