WormBase Tree Display for Gene: WBGene00000429

WBGene00000429 SMap: S_parent: Sequence: C27A12
  Identity: Version: 1
    Name: CGC_name: ceh-2 Person_evidence: WBPerson83
      Sequence_name: C27A12.5
      Molecular_name: C27A12.5
        C27A12.5.1
        CE20530
      Other_name: CELE_C27A12.5 Accession_evidence: NDB BX284601
      Public_name: ceh-2
    DB_info: Database: AceView gene 1G622
        WormQTL gene WBGene00000429
        WormFlux gene WBGene00000429
        NDB locus_tag CELE_C27A12.5
        Panther gene CAEEL|WormBase=WBGene00000429|UniProtKB=G5ECT8
          family PTHR24339
        NCBI gene 191615
        RefSeq protein NM_059345.7
        SwissProt UniProtAcc G5ECT8
        TREEFAM TREEFAM_ID TF317015
        UniProt_GCRP UniProtAcc G5ECT8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ceh
    Allele (36)
    Legacy_information: [C.elegansII] NMK. Encodes homeoprotein. Antibodies stain some pharyngeal cells just before pharyngeal morphogenesis. [Burglin et al. 1989]
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (42)
    Paralog: WBGene00018022 Caenorhabditis elegans From_analysis: Panther
      WBGene00044032 Caenorhabditis elegans From_analysis: Panther
      WBGene00012584 Caenorhabditis elegans From_analysis: Panther
      WBGene00000432 Caenorhabditis elegans From_analysis: Panther
      WBGene00000430 Caenorhabditis elegans From_analysis: Panther
      WBGene00022554 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: ceh-2 encodes a homeodomain protein homologous to Drosophila empty spiracles (EMS) and the vertebrate EMX1 and EMX2 proteins (OMIM:600034, 600035); although the exact biological role of CEH-2 in C. elegans development and/or behavior is not yet known, expression in pharyngeal neurons and muscle, as well as vulval cells (vulB1, vulB2, and vulC) at late stages of development suggests that CEH-2 may play a role in terminal differentiation events in diverse cell types. Paper_evidence: WBPaper00001190
            WBPaper00011600
            WBPaper00013312
            WBPaper00022408
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in neurons; pharynx; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in carcinoma (multiple) and stomach cancer. Is an ortholog of human EMX1 (empty spiracles homeobox 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3341)
      DOID:7474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3341)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3341)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3341)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3341)
      DOID:3907 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3341)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3341)
  Molecular_info: Corresponding_CDS: C27A12.5
    Corresponding_transcript: C27A12.5.1
    Other_sequence (11)
    Associated_feature: WBsf649210
      WBsf664313
      WBsf664314
      WBsf978314
      WBsf983821
      WBsf983822
      WBsf219523
      WBsf219524
      WBsf219525
      WBsf219526
    Transcription_factor: WBTranscriptionFactor000299
  Experimental_info: RNAi_result: WBRNAi00029244 Inferred_automatically: RNAi_primary
      WBRNAi00041295 Inferred_automatically: RNAi_primary
      WBRNAi00003026 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct (15)
    Construct_product: WBCnstr00037547
      WBCnstr00041955
    Antibody: WBAntibody00000654
    Microarray_results (18)
    Expression_cluster (95)
    Interaction (100)
  Map_info: Map: I Position: 0.702718 Error: 0.001508
    Positive: Positive_clone: C27A12 Inferred_automatically: From sequence, transcript, pseudogene data
        NE4
    Mapping_data: Multi_point: 4201
    Pseudo_map_position
  Reference (30)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene