| WBGene00000403 | SMap | S_parent | Sequence | B0034 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | casy-1 | Person_evidence | WBPerson284 |
| | | | | | WBPerson481 |
| | | Sequence_name | B0034.3 |
| | | Molecular_name (12) |
| | | Other_name | cdh-11 | Person_evidence | WBPerson698 |
| | | | CELE_B0034.3 | Accession_evidence | NDB | BX284602 |
| | | Public_name | casy-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 05 Jan 2006 11:22:20 | WBPerson2970 | Name_change | CGC_name | casy-1 |
| | | | | | | | Other_name | cdh-11 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | casy |
| | Allele (160) |
| | Strain | WBStrain00001795 |
| | | WBStrain00001794 |
| | | WBStrain00022694 |
| | | WBStrain00031601 |
| | | WBStrain00055675 |
| | | WBStrain00055105 |
| | | WBStrain00055673 |
| | RNASeq_FPKM (74) |
| | GO_annotation (32) |
| | Ortholog (46) |
| | Structured_description | Concise_description | casy-1 encodes a type I transmembrane protein with two extracellular cadherin domains and an LG/LNS domain that is the sole C. elegans calsyntenin/alcadein ortholog; genetic studies indicate that in C. elegans casy-1 activity is required, in parallel to the insulin-like signaling pathway, for several types of learning, including salt chemotaxis learning, temperature learning, olfactory adaptation, and integration of two sensory stimuli; large-scale RNAi experiments also suggest that casy-1 plays a role in embryonic development; casy-1 expression in adult animals is able to rescue salt chemotaxis learning defects, indicating that CASY-1 function in mature animals is sufficient to effect proper chemotactic behavior; in addition, CASY-1 expression in the ASER neuron, but not other neurons, rescues salt chemotaxis learning defects, indicating the CASY-1 can act solely in this chemosensory neuron for normal salt chemotaxis learning; a casy-1::GFP promoter fusion is expressed throughout the nervous system, including the head amphid sensory neurons, with additional expression seen in the intestine and gonadal sheath cells; a CASY-1::GFP protein fusion localizes to the plasma membrane and intracellular membranes of neuronal cell bodies, with specific N-terminal fusions indicative of CASY-1 ectodomain release into the extracellular space; domain-specific rescue experiments indicate that the secreted, proteolytically processed CASY-1 extracellular domain is sufficient to rescue salt chemotaxis learning defects. | Paper_evidence | WBPaper00004508 |
| | | | | | WBPaper00025054 |
| | | | | | WBPaper00031647 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 03 Apr 2008 00:00:00 |
| | | Automated_description | Predicted to enable several functions, including X11-like protein binding activity; amyloid-beta binding activity; and kinesin binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including extracellular region; neuromuscular junction; and neuronal cell body membrane. Expressed in neurons. Is an ortholog of human CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | B0034.3a |
| | | B0034.3b |
| | | B0034.3c |
| | | B0034.3d |
| | Corresponding_transcript | B0034.3a.1 |
| | | B0034.3b.1 |
| | | B0034.3c.1 |
| | | B0034.3d.1 |
| | Other_sequence (80) |
| | Associated_feature (29) |
| Experimental_info | RNAi_result (4) |
| | Expr_pattern (17) |
| | Drives_construct | WBCnstr00002178 |
| | | WBCnstr00004247 |
| | | WBCnstr00006267 |
| | | WBCnstr00006270 |
| | | WBCnstr00013090 |
| | | WBCnstr00013091 |
| | | WBCnstr00013376 |
| | | WBCnstr00023001 |
| | | WBCnstr00023062 |
| | | WBCnstr00037567 |
| | Construct_product | WBCnstr00006267 |
| | | WBCnstr00013091 |
| | | WBCnstr00018580 |
| | | WBCnstr00018581 |
| | | WBCnstr00018582 |
| | | WBCnstr00018583 |
| | | WBCnstr00019712 |
| | | WBCnstr00037567 |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00029359_1291 |
| | | WBPaper00030922:glycosylated_protein |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_CoreEnriched |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045971:tunicamycin_upregulated_control |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053039:Aspirin_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053664:ins-11(tm1053)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIN |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:CEP |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:Rectal_cell |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIS |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061340:URX |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061527:unc-13_19769-unc-13_278 |
| | | WBPaper00061651:AIA_enriched |
| | | WBPaper00061651:AIN_enriched |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:AVB_enriched |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:BAG_enriched |
| | | WBPaper00061651:BDU_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:MI_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PVT_enriched |
| | | WBPaper00061651:RIA_enriched |
| | | WBPaper00061651:RIB_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061651:RIH_enriched |
| | | WBPaper00061651:RIV_enriched |
| | | WBPaper00061651:RMF_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:URB_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064156:lipl-4(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4489_group_19 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032948:StarveUp1 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc6390]:Cluster_A |
| | Interaction (44) |
| Map_info | Map | II | Position | -0.800583 | Error | 0.01344 |
| | Positive | Positive_clone | B0034 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4194 |
| | | | 4440 |
| | Pseudo_map_position |
| Reference (27) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
