WormBase Tree Display for Gene: WBGene00000277

WBGene00000277 SMap: S_parent: Sequence: C23H4
  Identity: Version: 1
    Name: CGC_name: cab-1 Person_evidence: WBPerson287
      Sequence_name: C23H4.1
      Molecular_name: C23H4.1
        C23H4.1.1
        CE17435
        C23H4.1.2
      Other_name: CELE_C23H4.1 Accession_evidence: NDB BX284606
      Public_name: cab-1
    DB_info: Database: AceView gene XM818
        WormQTL gene WBGene00000277
        WormFlux gene WBGene00000277
        NDB locus_tag CELE_C23H4.1
        Panther gene CAEEL|WormBase=WBGene00000277|UniProtKB=Q93249
          family PTHR23352
        NCBI gene 181382
        RefSeq protein NM_077635.7
        SwissProt UniProtAcc Q93249
        TREEFAM TREEFAM_ID TF318443
        UniProt_GCRP UniProtAcc Q93249
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cab
    Allele (214)
    Strain: WBStrain00024085
    RNASeq_FPKM (74)
    GO_annotation: 00085642
      00085643
      00085644
      00085645
      00085646
      00085647
      00107160
    Ortholog (34)
    Structured_description: Concise_description: Novel protein which has a C-terminal motif weakly homologous to mouse NPDC-1 and is involved in synaptic regulation; it is expressed in various neurons including ventral cord and tail ganglion neurons; it physically interacts with AEX-3, which is a guanine nucleotide exchange factor for the Rab3 GTPase. Paper_evidence: WBPaper00004331
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in chemical synaptic transmission; positive regulation of anterior/posterior axon guidance; and ventral cord development. Predicted to be located in membrane and synapse. Is an ortholog of human NPDC1 (neural proliferation, differentiation and control 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C23H4.1
    Corresponding_transcript: C23H4.1.1
      C23H4.1.2
    Other_sequence (74)
    Associated_feature (22)
  Experimental_info: RNAi_result (22)
    Expr_pattern: Expr1016803
      Expr1030181
      Expr1145065
      Expr2009693
      Expr2027932
    Microarray_results (29)
    Expression_cluster: WBPaper00031040:Cluster_3
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040990:PA14_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045861:ash-2(tm1095)_upregulated
      WBPaper00046691:P1_enriched
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048810:CoQ-deficiency_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_specific
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:AIA
      WBPaper00061340:AIB
      WBPaper00061340:AIM
      WBPaper00061340:AIN
      WBPaper00061340:AIN_parent
      WBPaper00061340:AIY
      WBPaper00061340:ALA
      WBPaper00061340:AVL
      WBPaper00061340:AWC
      WBPaper00061340:DVC_parent
      WBPaper00061340:g2_parent
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:M4_parent
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:PVT
      WBPaper00061340:RIC
      WBPaper00061340:RIS
      WBPaper00061340:RME
      WBPaper00061340:RME_LR_parent
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:ccg-1_12351-ZC410.5
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061651:ADA_enriched
      WBPaper00061651:ADE_enriched
      WBPaper00061651:AIA_enriched
      WBPaper00061651:AIB_enriched
      WBPaper00061651:AIM_enriched
      WBPaper00061651:AIN_enriched
      WBPaper00061651:AIY_enriched
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:ALA_enriched
      WBPaper00061651:AQR_enriched
      WBPaper00061651:ASG_enriched
      WBPaper00061651:AUA_enriched
      WBPaper00061651:AVL_enriched
      WBPaper00061651:AVM_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:I5_enriched
      WBPaper00061651:I6_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:LUA_enriched
      WBPaper00061651:M1_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PHB_enriched
      WBPaper00061651:PHC_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVM_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:RIC_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RIF_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:RIP_enriched
      WBPaper00061651:RIS_enriched
      WBPaper00061651:RIV_enriched
      WBPaper00061651:RMD_LR_enriched
      WBPaper00061651:RMG_enriched
      WBPaper00061651:RMH_enriched
      WBPaper00061651:SDQ_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:URA_enriched
      WBPaper00061651:URB_enriched
      WBPaper00061651:URX_enriched
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065623:82
      WBPaper00065623:100
      WBPaper00065623:133
      WBPaper00065623:145
      WBPaper00065623:165
      WBPaper00065841:28_0
      WBPaper00065841:74_0
      WBPaper00065841:97_0
      WBPaper00065841:107_0
      WBPaper00065841:108_0
      WBPaper00065841:121_0
      WBPaper00065841:124_0
      WBPaper00065841:134_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_13
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_187
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032948:StarveUp3
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036286:Pattern_I
      WBPaper00037695:LD_3-day
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040876:mir-35_upregulated
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
    Interaction (31)
  Map_info: Map: X Position: 7.00899 Error: 0.003434
    Positive: Positive_clone: C23H4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4173
        4210
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene