WormBase Tree Display for Gene: WBGene00000253

WBGene00000253 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: bli-3 Person_evidence: WBPerson261
      Sequence_name: F56C11.1
      Molecular_name: F56C11.1
        F56C11.1.1
        CE28463
        F56C11.1.2
      Other_name: tag-31 CGC_data_submission
        duox-1 Paper_evidence: WBPaper00004841
            WBPaper00006395
          Person_evidence: WBPerson56
        CELE_F56C11.1 Accession_evidence: NDB BX284601
      Public_name: bli-3
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 07 Sep 2009 12:21:16 WBPerson9133 Name_change: CGC_name: duox-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bli
    Reference_allele: WBVar00143469
    Allele: WBVar00145548
      WBVar02149029
      WBVar02149018
      WBVar02149015
      WBVar02149022
      WBVar02149014
      WBVar02149016
      WBVar02149028
      WBVar02149027
      WBVar02149021
      WBVar02149023
      WBVar02149019
      WBVar02149024
      WBVar02149026
      WBVar02149030
      WBVar02149020
      WBVar02149025
      WBVar02125680
      WBVar02080483
      WBVar02080484
      WBVar00143469
      WBVar01375044
      WBVar00002441
      WBVar01488865
      WBVar00002446
      WBVar00002451
      WBVar01680458
      WBVar00002456
      WBVar01902196
      WBVar01493864
      WBVar00276736
      WBVar01402722
      WBVar01988295
      WBVar01929812
      WBVar00601110
      WBVar00146977
      WBVar00146978
      WBVar00146979
      WBVar00146980
      WBVar00146981
      WBVar00146982
      WBVar01499786
      WBVar00089581
      WBVar01529530
      WBVar00309564
      WBVar01529531
      WBVar00532123
      WBVar01529532
      WBVar01499619
      WBVar01761474
      WBVar01761475
      WBVar02125857
      WBVar02125858
      WBVar02125859
      WBVar00605262
      WBVar00605263
      WBVar00605264
      WBVar00605265
      WBVar00605266
      WBVar00323545
      WBVar00605267
      WBVar02083560
      WBVar00323546
      WBVar00605268
      WBVar00323547
      WBVar00605269
      WBVar00323548
      WBVar00605270
      WBVar00323549
      WBVar00605271
      WBVar00323550
      WBVar00605272
      WBVar00323551
      WBVar00605273
      WBVar00323552
      WBVar00605274
      WBVar00323553
      WBVar00605275
      WBVar00323554
      WBVar00323555
      WBVar00605276
      WBVar00323556
      WBVar00605277
      WBVar00323557
      WBVar00605278
      WBVar00323558
      WBVar00605279
      WBVar00605280
      WBVar00323559
      WBVar00323560
      WBVar00605281
      WBVar00259614
      WBVar00605282
      WBVar00323561
      WBVar00605283
      WBVar00323562
      WBVar00323563
      WBVar00235196
      WBVar00605284
      WBVar01376155
      WBVar00323564
      WBVar00605285
      WBVar00605286
      WBVar00323565
      WBVar00605287
      WBVar00323566
      WBVar01276773
      WBVar00605288
      WBVar00605289
      WBVar00605290
      WBVar00605291
      WBVar00605292
      WBVar00605293
      WBVar00605294
      WBVar00605295
      WBVar02145405
      WBVar00605296
      WBVar00605297
      WBVar00605298
      WBVar01711243
      WBVar00605299
      WBVar01711244
      WBVar00605300
      WBVar00605301
      WBVar01711245
      WBVar00605302
      WBVar00605303
      WBVar00605304
      WBVar00605305
      WBVar00605306
      WBVar00605307
      WBVar00605308
      WBVar00605309
      WBVar00605310
      WBVar00605311
      WBVar02125676
      WBVar02125677
      WBVar02125678
      WBVar02113420
    Legacy_information: e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. NA1.
      See also e767, n529
      [C.elegansII]e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. OA1: n529. [Brenner 1974; CB]
    Strain: WBStrain00005170
      WBStrain00005171
      WBStrain00005172
      WBStrain00005173
      WBStrain00026799
      WBStrain00026835
      WBStrain00027251
      WBStrain00028999
      WBStrain00037731
      WBStrain00004204
    RNASeq_FPKM (74)
    GO_annotation (36)
    Ortholog (42)
    Paralog: WBGene00018771 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: bli-3 encodes an NADPH oxidases of the dual oxidase (DUOX) variety that contains an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis. Paper_evidence: WBPaper00000031
            WBPaper00002665
            WBPaper00004841
            WBPaper00005747
            WBPaper00033104
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 19 Aug 2009 00:00:00
      Automated_description: Enables NAD(P)H oxidase H2O2-forming activity; heme binding activity; and peroxidase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; defense response to other organism; and post-embryonic development. Located in plasma membrane. Expressed in hypodermis; intestine; and neurons. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9281
    Potential_model: DOID:0050328 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:1498 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
      DOID:0112189 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:13273)
  Models_disease_asserted: WBDOannot00000626
  Molecular_info: Corresponding_CDS: F56C11.1
    Corresponding_transcript: F56C11.1.1
      F56C11.1.2
    Other_sequence (17)
    Associated_feature: WBsf717434
      WBsf982412
      WBsf982413
      WBsf982414
      WBsf1009036
      WBsf218873
      WBsf218874
  Experimental_info: RNAi_result (35)
    Expr_pattern: Expr2613
      Expr15757
      Expr1010236
      Expr1030163
      Expr1152411
      Expr2009629
      Expr2027868
    Drives_construct: WBCnstr00021138
      WBCnstr00037626
      WBCnstr00042508
    Construct_product: WBCnstr00015484
      WBCnstr00015485
      WBCnstr00015489
      WBCnstr00015491
      WBCnstr00037626
    Antibody: WBAntibody00000404
      WBAntibody00002391
      WBAntibody00002392
    Microarray_results (21)
    Expression_cluster (114)
    Interaction (22)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000096
  Map_info: Map: I Position: -19.1485 Error: 0.002825
    Well_ordered
    Positive: Inside_rearr: sDp2
      Positive_clone: F56C11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 1
        2504
        3941
        4741
        6080
        7166
        7167
        7169
      Multi_point (18)
      Pos_neg_data: 6276
        1026
        955
        4553
        4554
        4555
        4556
    Landmark_gene
  Reference (58)
  Remark: Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
  Method: Gene