WormBase Tree Display for Gene: WBGene00018771
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| WBGene00018771 | SMap | S_parent | Sequence | F53G12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | duox-2 | Paper_evidence | WBPaper00004841 | |||||
| Person_evidence | WBPerson56 | ||||||||
| Sequence_name | F53G12.3 | ||||||||
| Molecular_name | F53G12.3 | ||||||||
| F53G12.3.1 | |||||||||
| CE24999 | |||||||||
| Other_name | CELE_F53G12.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | duox-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 Sep 2009 12:21:16 | WBPerson9133 | Name_change | CGC_name | duox-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | duox | ||||||||
| Allele (99) | |||||||||
| Strain | WBStrain00005177 | ||||||||
| WBStrain00032202 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00000253 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | duox-2 encodes a large partial homolog of dual oxidase, with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; duox-2 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; duox-2 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; DUOX-2 has no visible expression pattern detectable by antibodies, implying very low or rare expression. | Paper_evidence | WBPaper00004841 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Sep 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of NADPH oxidase complex. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||
| DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| DOID:1498 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| DOID:0112189 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| Molecular_info | Corresponding_CDS | F53G12.3 | |||||||
| Corresponding_transcript | F53G12.3.1 | ||||||||
| Other_sequence (19) | |||||||||
| Associated_feature | WBsf982411 | ||||||||
| WBsf1009035 | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr1010521 | ||||||||
| Expr1038089 | |||||||||
| Expr1151983 | |||||||||
| Expr2011116 | |||||||||
| Expr2029352 | |||||||||
| Drives_construct | WBCnstr00026282 | ||||||||
| Construct_product | WBCnstr00026282 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (78) | |||||||||
| SAGE_tag (11) | |||||||||
| Interaction (22) | |||||||||
| Map_info | Map | I | Position | -19.1584 | Error | 0.002786 | |||
| Positive | Positive_clone | F53G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00004841 | ||||||||
| WBPaper00005747 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041408 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00055350 | |||||||||
| WBPaper00059817 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
