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WormBase Tree Display for Gene: WBGene00018771

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Name Class

WBGene00018771SMapS_parentSequenceF53G12
IdentityVersion2
NameCGC_nameduox-2Paper_evidenceWBPaper00004841
Person_evidenceWBPerson56
Sequence_nameF53G12.3
Molecular_nameF53G12.3
F53G12.3.1
CE24999
Other_nameCELE_F53G12.3Accession_evidenceNDBBX284601
Public_nameduox-2
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:00WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
207 Sep 2009 12:21:16WBPerson9133Name_changeCGC_nameduox-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classduox
Allele (99)
StrainWBStrain00005177
WBStrain00032202
RNASeq_FPKM (74)
GO_annotation (18)
Ortholog (44)
ParalogWBGene00000253Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionduox-2 encodes a large partial homolog of dual oxidase, with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; duox-2 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; duox-2 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; DUOX-2 has no visible expression pattern detectable by antibodies, implying very low or rare expression.Paper_evidenceWBPaper00004841
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated09 Sep 2009 00:00:00
Automated_descriptionPredicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of NADPH oxidase complex. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050328Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:1498Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:0112189Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
Molecular_infoCorresponding_CDSF53G12.3
Corresponding_transcriptF53G12.3.1
Other_sequence (19)
Associated_featureWBsf982411
WBsf1009035
Experimental_infoRNAi_result (29)
Expr_patternExpr1010521
Expr1038089
Expr1151983
Expr2011116
Expr2029352
Drives_constructWBCnstr00026282
Construct_productWBCnstr00026282
Microarray_results (21)
Expression_clusterWBPaper00030922:glycosylated_protein
WBPaper00031040:Cluster_5
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032528:L3_depleted
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_tiling
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00049377:MWCNT_upregulated
WBPaper00049626:UNC-75_target
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
WBPaper00053888:drh-3(rrr2)_downregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055226:adr-1(tm668)_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Allantoin_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Psora_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056284:ints-8(RNAi)_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00059537:ngn-1(ok2200)_upregulated
WBPaper00060703:nas-38(ok3407)_upregulated
WBPaper00060886:met-2(n4256)_upregulated
WBPaper00061340:pm6
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:sre-33-ZK1025.1_8337
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062590:Aging_downregulated_body-wall-muscle
WBPaper00064071:NHR-49_interacting
WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065841:27_0
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00036286:Pattern_I
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00041207:CE_dauer_down
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_48h
WBPaper00046548:dafachronic-acid_downregulated
[cgc6390]:Cluster_B
SAGE_tag (11)
Interaction (22)
Map_infoMapIPosition-19.1584Error0.002786
PositivePositive_cloneF53G12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00004841
WBPaper00005747
WBPaper00038491
WBPaper00041408
WBPaper00055090
WBPaper00055350
WBPaper00059817
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene