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WormBase Tree Display for Gene: WBGene00000176

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Name Class

WBGene00000176EvidencePerson_evidenceWBPerson548
SMapS_parentSequenceK02G10
IdentityVersion1
NameCGC_nameaqp-8Person_evidenceWBPerson300
Sequence_nameK02G10.7
Molecular_name (13)
Other_nameCELE_K02G10.7Accession_evidenceNDBBX284606
Public_nameaqp-8
DB_infoDatabaseAceViewgeneXF322
WormQTLgeneWBGene00000176
WormFluxgeneWBGene00000176
NDBlocus_tagCELE_K02G10.7
PanthergeneCAEEL|WormBase=WBGene00000176|UniProtKB=Q7Z137
familyPTHR43829
NCBIgene180744
RefSeqproteinNM_001361799.3
NM_001029587.3
NM_001361800.3
NM_001373283.3
TREEFAMTREEFAM_IDTF313173
TrEMBLUniProtAccQ7Z138
A0A2K5AU16
A0A2K5AU20
Q7Z137
UniProt_GCRPUniProtAccQ7Z138
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classaqp
Allele (46)
StrainWBStrain00032798
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (40)
ParalogWBGene00000169Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000170Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000171Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000175Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013272Caenorhabditis elegansFrom_analysisPanther
WBGene00000172Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000173Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00000174Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionaqp-8 encodes, by alternative splicing, two isoforms of a putative aquaglyceroporin with no known substrate, since AQP-8 expressed in Xenopus oocytes has no effect on water, glycerol, or urea permeability; loss of AQP-8 activity via mutation or RNAi results in no obvious defects; however, AQP-8, in conjunction with AQP-2, AQP-3, and AQP-4, is weakly required for recovery from hypotonic stress; AQP-8 is expressed in the excretory cell.Paper_evidenceWBPaper00029039
WBPaper00030907
Curator_confirmedWBPerson567
Date_last_updated12 Aug 2007 00:00:00
Automated_descriptionPredicted to enable glycerol channel activity and water channel activity. Predicted to be involved in glycerol transmembrane transport and water transport. Located in cell surface. Expressed in several structures, including excretory system; germ line; intestinal cell; non-striated muscle; and ray. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4724Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:636)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:0060180Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
DOID:11981Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:640)
Molecular_infoCorresponding_CDSK02G10.7a
K02G10.7b
K02G10.7c
K02G10.7d
Corresponding_CDS_historyK02G10.7:wp101
K02G10.7a:wp271
Corresponding_transcriptK02G10.7a.1
K02G10.7b.1
K02G10.7b.2
K02G10.7c.1
K02G10.7d.1
Other_sequence (33)
Associated_featureWBsf034361
WBsf216759
WBsf718571
WBsf1005038
WBsf1005039
WBsf1022838
WBsf237306
WBsf237307
Experimental_infoRNAi_resultWBRNAi00033899Inferred_automaticallyRNAi_primary
WBRNAi00075618Inferred_automaticallyRNAi_primary
WBRNAi00101340Inferred_automaticallyRNAi_primary
WBRNAi00016499Inferred_automaticallyRNAi_primary
WBRNAi00101341Inferred_automaticallyRNAi_primary
WBRNAi00049771Inferred_automaticallyRNAi_primary
WBRNAi00000991Inferred_automaticallyRNAi_primary
Expr_patternExpr4778
Expr4818
Expr10636
Expr13456
Expr1012328
Expr1030100
Expr1153486
Expr2009385
Expr2027621
Drives_constructWBCnstr00004199
WBCnstr00012238
WBCnstr00017213
WBCnstr00017563
WBCnstr00017564
WBCnstr00037685
Construct_productWBCnstr00017136
WBCnstr00017213
WBCnstr00017563
WBCnstr00017565
WBCnstr00037685
Microarray_results (21)
Expression_cluster (227)
InteractionWBInteraction000107213
WBInteraction000120023
WBInteraction000120371
WBInteraction000182167
WBInteraction000190164
WBInteraction000197227
WBInteraction000197989
WBInteraction000204412
WBInteraction000206279
WBInteraction000214559
WBInteraction000218870
WBInteraction000221545
WBInteraction000222904
WBInteraction000230464
WBInteraction000230715
WBInteraction000250783
WBInteraction000258110
WBInteraction000273659
WBInteraction000277903
WBInteraction000279004
WBInteraction000279329
WBInteraction000284000
WBInteraction000284330
WBInteraction000284816
WBInteraction000286034
WBInteraction000286919
WBInteraction000287879
WBInteraction000291847
WBInteraction000291869
WBInteraction000294926
WBInteraction000296497
WBInteraction000301499
WBInteraction000302490
WBInteraction000310398
WBInteraction000320611
WBInteraction000321272
WBInteraction000326056
WBInteraction000330462
WBInteraction000335989
WBInteraction000337633
WBInteraction000340089
WBInteraction000342963
WBInteraction000344693
WBInteraction000347505
WBInteraction000352787
WBInteraction000354647
WBInteraction000357581
WBInteraction000360453
WBInteraction000363424
WBInteraction000363825
WBInteraction000365073
WBInteraction000366788
WBInteraction000369948
WBInteraction000376611
WBInteraction000378737
WBInteraction000378804
WBInteraction000383270
WBInteraction000385219
WBInteraction000388746
WBInteraction000389246
WBInteraction000391261
WBInteraction000392161
WBInteraction000398607
WBInteraction000399909
WBInteraction000404135
WBInteraction000410434
WBInteraction000410912
WBInteraction000414561
WBInteraction000414884
WBInteraction000417337
WBInteraction000417551
WBInteraction000420235
WBInteraction000421123
WBInteraction000426447
WBInteraction000431083
WBInteraction000432625
WBInteraction000435096
WBInteraction000435604
WBInteraction000438670
WBInteraction000439147
WBInteraction000442600
WBInteraction000442854
WBInteraction000444300
WBInteraction000446368
WBInteraction000446677
WBInteraction000450923
WBInteraction000452724
WBInteraction000453879
WBInteraction000457079
WBInteraction000457591
WBInteraction000457826
WBInteraction000458150
WBInteraction000458468
WBInteraction000459096
WBInteraction000462099
WBInteraction000468092
WBInteraction000468463
WBInteraction000468571
WBInteraction000469239
WBInteraction000470876
WBInteraction000472954
WBInteraction000473146
WBInteraction000474036
WBInteraction000474037
WBInteraction000474402
WBInteraction000475065
WBInteraction000475203
WBInteraction000502987
WBInteraction000504102
WBInteraction000519445
WBInteraction000551390
WBInteraction000553246
WBInteraction000571002
WBInteraction000571071
WBInteraction000579856
Map_infoMapXPosition-6.86689Error0.013931
PositivePositive_cloneK02G10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5264
4264
5494
Pseudo_map_position
Reference (12)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene