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WormBase Tree Display for Gene: WBGene00000156

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Name Class

WBGene00000156SMapS_parentSequenceK04G2
IdentityVersion1
NameCGC_nameapr-1Person_evidenceWBPerson419
Sequence_nameK04G2.8
Molecular_nameK04G2.8a
K04G2.8a.1
CE06102
K04G2.8b
CE18016
K04G2.8c
CE51809
K04G2.8b.1
K04G2.8c.1
Other_nameAPCPaper_evidenceWBPaper00044307
CELE_K04G2.8Accession_evidenceNDBBX284601
Public_nameapr-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classapr
Allele (69)
Possibly_affected_byWBVar02153202
Legacy_information[Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01]
StrainWBStrain00037280
WBStrain00000140
WBStrain00008585
WBStrain00024309
RNASeq_FPKM (74)
GO_annotation (77)
Ortholog (41)
Structured_descriptionConcise_descriptionThe apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway.Paper_evidence (12)
Curator_confirmedWBPerson324
WBPerson567
Date_last_updated25 May 2011 00:00:00
Automated_descriptionEnables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (20)
Molecular_infoCorresponding_CDSK04G2.8a
K04G2.8b
K04G2.8c
Corresponding_transcriptK04G2.8a.1
K04G2.8b.1
K04G2.8c.1
Other_sequenceAF013950
CGC00612_1
ACC25655_1
EX555243.1
CBC06635_1
Associated_featureWBsf656598
WBsf218114
Experimental_infoRNAi_resultWBRNAi00101650Inferred_automaticallyRNAi_primary
WBRNAi00101537Inferred_automaticallyRNAi_primary
WBRNAi00062614Inferred_automaticallyRNAi_primary
WBRNAi00091594Inferred_automaticallyRNAi_primary
WBRNAi00099035Inferred_automaticallyRNAi_primary
WBRNAi00101533Inferred_automaticallyRNAi_primary
WBRNAi00101666Inferred_automaticallyRNAi_primary
WBRNAi00091593Inferred_automaticallyRNAi_primary
WBRNAi00099029Inferred_automaticallyRNAi_primary
WBRNAi00101535Inferred_automaticallyRNAi_primary
WBRNAi00099037Inferred_automaticallyRNAi_primary
WBRNAi00077089Inferred_automaticallyRNAi_primary
WBRNAi00112568Inferred_automaticallyRNAi_primary
WBRNAi00025870Inferred_automaticallyRNAi_primary
WBRNAi00101610Inferred_automaticallyRNAi_primary
WBRNAi00062622Inferred_automaticallyRNAi_primary
WBRNAi00098844Inferred_automaticallyRNAi_primary
WBRNAi00091596Inferred_automaticallyRNAi_primary
WBRNAi00101358Inferred_automaticallyRNAi_primary
WBRNAi00101857Inferred_automaticallyRNAi_primary
WBRNAi00022931Inferred_automaticallyRNAi_primary
WBRNAi00062631Inferred_automaticallyRNAi_primary
WBRNAi00098802Inferred_automaticallyRNAi_primary
WBRNAi00099036Inferred_automaticallyRNAi_primary
WBRNAi00098925Inferred_automaticallyRNAi_primary
WBRNAi00092551Inferred_automaticallyRNAi_primary
WBRNAi00068826Inferred_automaticallyRNAi_primary
WBRNAi00099040Inferred_automaticallyRNAi_primary
WBRNAi00084512Inferred_automaticallyRNAi_primary
WBRNAi00101630Inferred_automaticallyRNAi_primary
WBRNAi00091565Inferred_automaticallyRNAi_primary
WBRNAi00099005Inferred_automaticallyRNAi_primary
WBRNAi00061053Inferred_automaticallyRNAi_primary
WBRNAi00091598Inferred_automaticallyRNAi_primary
WBRNAi00003922Inferred_automaticallyRNAi_primary
WBRNAi00098815Inferred_automaticallyRNAi_primary
WBRNAi00068307Inferred_automaticallyRNAi_primary
WBRNAi00110439Inferred_automaticallyRNAi_primary
WBRNAi00070927Inferred_automaticallyRNAi_primary
WBRNAi00062618Inferred_automaticallyRNAi_primary
WBRNAi00091588Inferred_automaticallyRNAi_primary
WBRNAi00077086Inferred_automaticallyRNAi_primary
WBRNAi00022930Inferred_automaticallyRNAi_primary
WBRNAi00099031Inferred_automaticallyRNAi_primary
WBRNAi00091584Inferred_automaticallyRNAi_primary
WBRNAi00001890Inferred_automaticallyRNAi_primary
WBRNAi00092772Inferred_automaticallyRNAi_primary
WBRNAi00101668Inferred_automaticallyRNAi_primary
WBRNAi00101640Inferred_automaticallyRNAi_primary
WBRNAi00068229Inferred_automaticallyRNAi_primary
WBRNAi00062621Inferred_automaticallyRNAi_primary
WBRNAi00025869Inferred_automaticallyRNAi_primary
WBRNAi00101468Inferred_automaticallyRNAi_primary
WBRNAi00070925Inferred_automaticallyRNAi_primary
WBRNAi00101853Inferred_automaticallyRNAi_primary
WBRNAi00101676Inferred_automaticallyRNAi_primary
WBRNAi00068306Inferred_automaticallyRNAi_primary
WBRNAi00084511Inferred_automaticallyRNAi_primary
WBRNAi00077088Inferred_automaticallyRNAi_primary
WBRNAi00111668Inferred_automaticallyRNAi_primary
WBRNAi00101660Inferred_automaticallyRNAi_primary
WBRNAi00101815Inferred_automaticallyRNAi_primary
WBRNAi00077305Inferred_automaticallyRNAi_primary
WBRNAi00061056Inferred_automaticallyRNAi_primary
WBRNAi00022928Inferred_automaticallyRNAi_primary
WBRNAi00092550Inferred_automaticallyRNAi_primary
WBRNAi00101709Inferred_automaticallyRNAi_primary
WBRNAi00068308Inferred_automaticallyRNAi_primary
WBRNAi00101814Inferred_automaticallyRNAi_primary
WBRNAi00068305Inferred_automaticallyRNAi_primary
WBRNAi00101625Inferred_automaticallyRNAi_primary
WBRNAi00101530Inferred_automaticallyRNAi_primary
WBRNAi00064700Inferred_automaticallyRNAi_primary
WBRNAi00068304Inferred_automaticallyRNAi_primary
WBRNAi00098982Inferred_automaticallyRNAi_primary
WBRNAi00101539Inferred_automaticallyRNAi_primary
WBRNAi00077090Inferred_automaticallyRNAi_primary
WBRNAi00101508Inferred_automaticallyRNAi_primary
WBRNAi00101600Inferred_automaticallyRNAi_primary
WBRNAi00091595Inferred_automaticallyRNAi_primary
WBRNAi00091580Inferred_automaticallyRNAi_primary
WBRNAi00077087Inferred_automaticallyRNAi_primary
WBRNAi00099041Inferred_automaticallyRNAi_primary
WBRNAi00098848Inferred_automaticallyRNAi_primary
WBRNAi00077292Inferred_automaticallyRNAi_primary
WBRNAi00064496Inferred_automaticallyRNAi_primary
WBRNAi00098980Inferred_automaticallyRNAi_primary
WBRNAi00084510Inferred_automaticallyRNAi_primary
WBRNAi00098846Inferred_automaticallyRNAi_primary
WBRNAi00098981Inferred_automaticallyRNAi_primary
WBRNAi00062617Inferred_automaticallyRNAi_primary
WBRNAi00091592Inferred_automaticallyRNAi_primary
WBRNAi00033968Inferred_automaticallyRNAi_primary
WBRNAi00091581Inferred_automaticallyRNAi_primary
WBRNAi00101465Inferred_automaticallyRNAi_primary
WBRNAi00098801Inferred_automaticallyRNAi_primary
WBRNAi00098995Inferred_automaticallyRNAi_primary
WBRNAi00101663Inferred_automaticallyRNAi_primary
WBRNAi00099004Inferred_automaticallyRNAi_primary
WBRNAi00070928Inferred_automaticallyRNAi_primary
WBRNAi00098425Inferred_automaticallyRNAi_primary
WBRNAi00101518Inferred_automaticallyRNAi_primary
WBRNAi00022929Inferred_automaticallyRNAi_primary
WBRNAi00049941Inferred_automaticallyRNAi_primary
Expr_patternExpr1046
Expr4600
Expr12119
Expr12448
Expr15118
Expr1028112
Expr1030085
Expr1153646
Expr2009365
Expr2027601
Drives_constructWBCnstr00005188
WBCnstr00007256
WBCnstr00009075
WBCnstr00009116
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
Construct_productWBCnstr00000526
WBCnstr00007257
WBCnstr00007258
WBCnstr00009057
WBCnstr00009075
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
AntibodyWBAntibody00000276
WBAntibody00000277
Microarray_results (25)
Expression_cluster (124)
Interaction (179)
WBProcessWBbiopr:00000073
Map_infoMapIPosition2.43771Error0.002342
PositivePositive_cloneK04G2Person_evidenceWBPerson524
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4159
4893
5616
Pseudo_map_position
Reference (108)
PictureWBPicture0000013084
RemarkData extracted from Rocheleau et al. (1997)
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene