WormBase Tree Display for Gene: WBGene00000156
expand all nodes | collapse all nodes | view schema
| WBGene00000156 | SMap | S_parent | Sequence | K04G2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | apr-1 | Person_evidence | WBPerson419 | |||||
| Sequence_name | K04G2.8 | ||||||||
| Molecular_name | K04G2.8a | ||||||||
| K04G2.8a.1 | |||||||||
| CE06102 | |||||||||
| K04G2.8b | |||||||||
| CE18016 | |||||||||
| K04G2.8c | |||||||||
| CE51809 | |||||||||
| K04G2.8b.1 | |||||||||
| K04G2.8c.1 | |||||||||
| Other_name | APC | Paper_evidence | WBPaper00044307 | ||||||
| CELE_K04G2.8 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | apr-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | apr | ||||||||
| Allele (69) | |||||||||
| Possibly_affected_by | WBVar02153202 | ||||||||
| Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | ||||||||
| Strain | WBStrain00037280 | ||||||||
| WBStrain00000140 | |||||||||
| WBStrain00008585 | |||||||||
| WBStrain00024309 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (77) | |||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 May 2011 00:00:00 | ||||||||
| Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (20) | ||||||||
| Molecular_info | Corresponding_CDS | K04G2.8a | |||||||
| K04G2.8b | |||||||||
| K04G2.8c | |||||||||
| Corresponding_transcript | K04G2.8a.1 | ||||||||
| K04G2.8b.1 | |||||||||
| K04G2.8c.1 | |||||||||
| Other_sequence | AF013950 | ||||||||
| CGC00612_1 | |||||||||
| ACC25655_1 | |||||||||
| EX555243.1 | |||||||||
| CBC06635_1 | |||||||||
| Associated_feature | WBsf656598 | ||||||||
| WBsf218114 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00101650 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00101537 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062614 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091594 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099035 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101533 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101666 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091593 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099029 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101535 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099037 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077089 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112568 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025870 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101610 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062622 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098844 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091596 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101358 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101857 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022931 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062631 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098802 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099036 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098925 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092551 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068826 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099040 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084512 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101630 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091565 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099005 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061053 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091598 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003922 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098815 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068307 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110439 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070927 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062618 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091588 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077086 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022930 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099031 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091584 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001890 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092772 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101668 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101640 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068229 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062621 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025869 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101468 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070925 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101853 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101676 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068306 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084511 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077088 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00111668 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101660 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101815 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077305 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061056 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022928 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092550 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101709 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068308 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101814 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068305 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101625 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101530 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064700 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068304 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098982 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101539 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077090 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101508 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101600 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091595 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091580 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077087 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099041 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098848 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077292 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064496 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098980 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00084510 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098846 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098981 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062617 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091592 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033968 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091581 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101465 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098801 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098995 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101663 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099004 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070928 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098425 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101518 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022929 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049941 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1046 | ||||||||
| Expr4600 | |||||||||
| Expr12119 | |||||||||
| Expr12448 | |||||||||
| Expr15118 | |||||||||
| Expr1028112 | |||||||||
| Expr1030085 | |||||||||
| Expr1153646 | |||||||||
| Expr2009365 | |||||||||
| Expr2027601 | |||||||||
| Drives_construct | WBCnstr00005188 | ||||||||
| WBCnstr00007256 | |||||||||
| WBCnstr00009075 | |||||||||
| WBCnstr00009116 | |||||||||
| WBCnstr00012108 | |||||||||
| WBCnstr00016098 | |||||||||
| WBCnstr00020198 | |||||||||
| WBCnstr00021087 | |||||||||
| WBCnstr00037698 | |||||||||
| Construct_product | WBCnstr00000526 | ||||||||
| WBCnstr00007257 | |||||||||
| WBCnstr00007258 | |||||||||
| WBCnstr00009057 | |||||||||
| WBCnstr00009075 | |||||||||
| WBCnstr00012108 | |||||||||
| WBCnstr00016098 | |||||||||
| WBCnstr00020198 | |||||||||
| WBCnstr00021087 | |||||||||
| WBCnstr00037698 | |||||||||
| Antibody | WBAntibody00000276 | ||||||||
| WBAntibody00000277 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction | WBInteraction000000509 | ||||||||
| WBInteraction000000575 | |||||||||
| WBInteraction000000753 | |||||||||
| WBInteraction000000754 | |||||||||
| WBInteraction000001726 | |||||||||
| WBInteraction000002340 | |||||||||
| WBInteraction000002342 | |||||||||
| WBInteraction000002585 | |||||||||
| WBInteraction000002710 | |||||||||
| WBInteraction000002782 | |||||||||
| WBInteraction000003344 | |||||||||
| WBInteraction000003458 | |||||||||
| WBInteraction000006023 | |||||||||
| WBInteraction000006227 | |||||||||
| WBInteraction000007683 | |||||||||
| WBInteraction000008079 | |||||||||
| WBInteraction000008080 | |||||||||
| WBInteraction000009426 | |||||||||
| WBInteraction000009453 | |||||||||
| WBInteraction000009517 | |||||||||
| WBInteraction000009576 | |||||||||
| WBInteraction000009639 | |||||||||
| WBInteraction000009662 | |||||||||
| WBInteraction000009925 | |||||||||
| WBInteraction000028572 | |||||||||
| WBInteraction000028907 | |||||||||
| WBInteraction000032887 | |||||||||
| WBInteraction000033010 | |||||||||
| WBInteraction000034034 | |||||||||
| WBInteraction000034911 | |||||||||
| WBInteraction000035587 | |||||||||
| WBInteraction000035961 | |||||||||
| WBInteraction000035984 | |||||||||
| WBInteraction000036518 | |||||||||
| WBInteraction000036519 | |||||||||
| WBInteraction000036550 | |||||||||
| WBInteraction000036758 | |||||||||
| WBInteraction000037406 | |||||||||
| WBInteraction000038393 | |||||||||
| WBInteraction000039618 | |||||||||
| WBInteraction000040188 | |||||||||
| WBInteraction000040656 | |||||||||
| WBInteraction000040733 | |||||||||
| WBInteraction000042660 | |||||||||
| WBInteraction000043782 | |||||||||
| WBInteraction000044304 | |||||||||
| WBInteraction000045863 | |||||||||
| WBInteraction000047105 | |||||||||
| WBInteraction000047526 | |||||||||
| WBInteraction000048030 | |||||||||
| WBInteraction000048532 | |||||||||
| WBInteraction000048907 | |||||||||
| WBInteraction000049265 | |||||||||
| WBInteraction000049460 | |||||||||
| WBInteraction000049616 | |||||||||
| WBInteraction000049943 | |||||||||
| WBInteraction000049949 | |||||||||
| WBInteraction000052601 | |||||||||
| WBInteraction000052602 | |||||||||
| WBInteraction000122526 | |||||||||
| WBInteraction000126449 | |||||||||
| WBInteraction000126689 | |||||||||
| WBInteraction000127394 | |||||||||
| WBInteraction000127428 | |||||||||
| WBInteraction000136069 | |||||||||
| WBInteraction000161291 | |||||||||
| WBInteraction000161292 | |||||||||
| WBInteraction000163171 | |||||||||
| WBInteraction000163172 | |||||||||
| WBInteraction000165152 | |||||||||
| WBInteraction000165478 | |||||||||
| WBInteraction000165479 | |||||||||
| WBInteraction000165480 | |||||||||
| WBInteraction000165481 | |||||||||
| WBInteraction000166114 | |||||||||
| WBInteraction000166122 | |||||||||
| WBInteraction000168467 | |||||||||
| WBInteraction000181728 | |||||||||
| WBInteraction000197741 | |||||||||
| WBInteraction000201561 | |||||||||
| WBInteraction000215885 | |||||||||
| WBInteraction000220431 | |||||||||
| WBInteraction000235718 | |||||||||
| WBInteraction000236547 | |||||||||
| WBInteraction000245920 | |||||||||
| WBInteraction000246352 | |||||||||
| WBInteraction000251918 | |||||||||
| WBInteraction000259481 | |||||||||
| WBInteraction000269634 | |||||||||
| WBInteraction000288175 | |||||||||
| WBInteraction000299490 | |||||||||
| WBInteraction000305218 | |||||||||
| WBInteraction000313782 | |||||||||
| WBInteraction000335865 | |||||||||
| WBInteraction000352929 | |||||||||
| WBInteraction000355014 | |||||||||
| WBInteraction000356176 | |||||||||
| WBInteraction000369335 | |||||||||
| WBInteraction000375807 | |||||||||
| WBInteraction000389718 | |||||||||
| WBInteraction000394134 | |||||||||
| WBInteraction000400830 | |||||||||
| WBInteraction000411677 | |||||||||
| WBInteraction000418748 | |||||||||
| WBInteraction000427030 | |||||||||
| WBInteraction000430041 | |||||||||
| WBInteraction000442259 | |||||||||
| WBInteraction000444338 | |||||||||
| WBInteraction000500035 | |||||||||
| WBInteraction000500036 | |||||||||
| WBInteraction000502192 | |||||||||
| WBInteraction000502796 | |||||||||
| WBInteraction000502797 | |||||||||
| WBInteraction000502798 | |||||||||
| WBInteraction000502799 | |||||||||
| WBInteraction000502801 | |||||||||
| WBInteraction000503435 | |||||||||
| WBInteraction000505124 | |||||||||
| WBInteraction000505125 | |||||||||
| WBInteraction000505126 | |||||||||
| WBInteraction000505127 | |||||||||
| WBInteraction000517877 | |||||||||
| WBInteraction000519244 | |||||||||
| WBInteraction000519245 | |||||||||
| WBInteraction000519250 | |||||||||
| WBInteraction000519251 | |||||||||
| WBInteraction000519252 | |||||||||
| WBInteraction000519253 | |||||||||
| WBInteraction000519254 | |||||||||
| WBInteraction000519255 | |||||||||
| WBInteraction000520246 | |||||||||
| WBInteraction000521746 | |||||||||
| WBInteraction000521750 | |||||||||
| WBInteraction000521853 | |||||||||
| WBInteraction000521875 | |||||||||
| WBInteraction000521881 | |||||||||
| WBInteraction000521882 | |||||||||
| WBInteraction000521883 | |||||||||
| WBInteraction000521884 | |||||||||
| WBInteraction000522263 | |||||||||
| WBInteraction000522264 | |||||||||
| WBInteraction000522281 | |||||||||
| WBInteraction000522308 | |||||||||
| WBInteraction000522316 | |||||||||
| WBInteraction000523960 | |||||||||
| WBInteraction000524831 | |||||||||
| WBInteraction000539198 | |||||||||
| WBInteraction000541599 | |||||||||
| WBInteraction000541603 | |||||||||
| WBInteraction000541779 | |||||||||
| WBInteraction000541780 | |||||||||
| WBInteraction000543618 | |||||||||
| WBInteraction000543619 | |||||||||
| WBInteraction000543620 | |||||||||
| WBInteraction000543621 | |||||||||
| WBInteraction000543622 | |||||||||
| WBInteraction000543623 | |||||||||
| WBInteraction000543624 | |||||||||
| WBInteraction000543625 | |||||||||
| WBInteraction000543626 | |||||||||
| WBInteraction000543627 | |||||||||
| WBInteraction000543628 | |||||||||
| WBInteraction000543629 | |||||||||
| WBInteraction000543630 | |||||||||
| WBInteraction000543631 | |||||||||
| WBInteraction000547298 | |||||||||
| WBInteraction000547711 | |||||||||
| WBInteraction000556044 | |||||||||
| WBInteraction000556045 | |||||||||
| WBInteraction000556046 | |||||||||
| WBInteraction000557664 | |||||||||
| WBInteraction000557671 | |||||||||
| WBInteraction000557678 | |||||||||
| WBInteraction000557685 | |||||||||
| WBInteraction000557692 | |||||||||
| WBInteraction000557699 | |||||||||
| WBInteraction000560328 | |||||||||
| WBInteraction000578733 | |||||||||
| WBInteraction000582080 | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | I | Position | 2.43771 | Error | 0.002342 | |||
| Positive | Positive_clone | K04G2 | Person_evidence | WBPerson524 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4159 | |||||||
| 4893 | |||||||||
| 5616 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (108) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Remark | Data extracted from Rocheleau et al. (1997) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
