WormBase Tree Display for Gene: WBGene00000100

WBGene00000100 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 3
    Name: CGC_name: ajm-1 Person_evidence: WBPerson240
      Sequence_name: C25A11.4
      Molecular_name (42)
      Other_name: jam-1
        H08J11.c Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        H08J11.a
        H08J11.b
        CELE_C25A11.4 Accession_evidence: NDB BX284606
      Public_name: ajm-1
    DB_info: Database (10)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 01 Jul 2016 14:56:15 WBPerson1983 Event: Acquires_merge: WBGene00044785
        3 01 Jul 2016 14:56:15 WBPerson1983 Event: Acquires_merge: WBGene00019173
      Acquires_merge: WBGene00044785
        WBGene00019173
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ajm
    Allele (507)
    Legacy_information: [Raich WB, Hardin JD] No mutants known. Encodes protein recognized by monoclonal antibody MH27, associated with apical cell-cell junctions. Predicted gene C25A11.4 + C25A11.3
    Strain (22)
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (27)
    Structured_description: Concise_description: ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo; AJM-1 contains a coiled-coil motif; AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo; AJM-1 is mislocalized in a dlg-1(RNAi) background; LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia; CLC-1 colocalizes with AJM-1; vab-9 mutations enhance the adhesion defects of ajm-1 mutants; ajm-1 is expressed at the apical borders of all epithelia. Paper_evidence: WBPaper00004765
            WBPaper00004961
            WBPaper00005194
            WBPaper00005946
            WBPaper00005969
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cytoskeletal protein binding activity. Involved in cell-cell junction organization and embryo development. Located in apicolateral plasma membrane; cell-cell junction; and plasma membrane bounded cell projection. Expressed in several structures, including arcade cell and epithelial cell. Is an ortholog of human AJM1 (apical junction component 1 homolog). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS (13)
    Corresponding_CDS_history: C25A11.4b:wp254
      C25A11.4c:wp254
      C25A11.4d:wp254
      C25A11.4e:wp254
    Corresponding_transcript (16)
    Other_sequence (84)
    Associated_feature (76)
  Experimental_info: RNAi_result (26)
    Expr_pattern (20)
    Drives_construct (23)
    Construct_product (11)
    Antibody: WBAntibody00000055
      WBAntibody00001322
    Microarray_results (94)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00024505:pharyngeal_enriched
      WBPaper00029359_1166
      WBPaper00029359_1197
      WBPaper00029359_1243
      WBPaper00029359_1291
      WBPaper00029359_1336
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00044246:pgrn-1_ced-1_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00044786:lem-2(tm1582)_upregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046121:ecdoderm_unique
      WBPaper00046887:WNT-target
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049482:P.mirabilis_48h_regulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_enriched
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053888:drh-3(rrr2)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:HMG-4_interacting_protein
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056855:his-72(uge40)_downregulated
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:IL1_parent
      WBPaper00061340:ILso
      WBPaper00061340:mc1
      WBPaper00061340:mc2
      WBPaper00061340:mc3
      WBPaper00061340:NSM_parent
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:pm1_pm2
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061340:pm8
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061377:PAN-1_interacting
      WBPaper00061527:176662_at-Y53F4B.16
      WBPaper00061527:hlh-30_18579-unc-43_21739
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:npp-8_4355-afd-1_4796
      WBPaper00061527:sre-33-ZK1025.1_8337
      WBPaper00061527:Y37D8A.16-F54D1.6_15313
      WBPaper00061651:I3_enriched
      WBPaper00061651:M2_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064122:vulva_transcriptome
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064789:Day12_vs_Day1_upregulated_neuron
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065029:cadmium_upregulated
      WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065841:9_0
      WBPaper00065841:11_2
      WBPaper00065841:53_0
      WBPaper00065841:56_0
      WBPaper00065841:116_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_3
      cgc4386_cluster_6_4
      cgc4386_cluster_6_5
      cgc4489_group_22
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q50_down
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045294:0.1uM_TBBP_downregulated
      WBPaper00045294:50uM_DBAA_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00049311:sAg-MNP_regulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_C
    Interaction (104)
  Map_info: Map: X Position: 0.672056 Error: 0.047992
    Positive: Positive_clone: C25A11 Person_evidence: WBPerson506
          Author_evidence: Hardin JD
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4150
    Pseudo_map_position
  Reference (133)
  Remark: .3 gene was merged with .4 gene
    Sequence connection from [Koppen M, Hardin JD]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene