WormBase Tree Display for Gene: WBGene00000002

WBGene00000002 Evidence: Author_evidence: Veljkovic E
      Verrey F
  SMap: S_parent: Sequence: F27C8
  Identity: Version: 1
    Name: CGC_name: aat-1
      Sequence_name: F27C8.1
      Molecular_name: F27C8.1
        F27C8.1.1
        CE03266
      Other_name: CELE_F27C8.1 Accession_evidence: NDB BX284604
      Public_name: aat-1
    DB_info: Database: AceView gene 4K364
        WormQTL gene WBGene00000002
        WormFlux gene WBGene00000002
        NDB locus_tag CELE_F27C8.1
        Panther gene CAEEL|WormBase=WBGene00000002|UniProtKB=Q19834
          family PTHR11785
        NCBI gene 177793
        RefSeq protein NM_069306.7
        TrEMBL UniProtAcc Q19834
        UniProt_GCRP UniProtAcc Q19834
        OMIM gene 603593
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aat
    Allele (38)
    Strain: WBStrain00054846
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog: WBGene00072228 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00039142 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00149684 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00155266 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128643 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00216201 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00110222 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00223909 Brugia malayi From_analysis: WormBase-Compara
      WBGene00269017 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g8641 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g7466 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g19943 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g21159 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g8095 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g7945 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g14541 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g993 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g13014 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g24984 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g25928 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g22231 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_17799.g25802 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_IV.g13239 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g8220 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00186.g6569 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_11900 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_013471 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05703 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g13204 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40340700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g11359 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242584 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00268061 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00297255 Trichuris muris From_analysis: WormBase-Compara
      WBGene00299376 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003287 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      SGD:S000001028 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0039844 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-000607-21 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
      ZFIN:ZDB-GENE-121105-2 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-070705-534 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
      ZFIN:ZDB-GENE-080116-1 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-051127-5 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
      ZFIN:ZDB-GENE-080818-4 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-121120-2 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030616-586 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:11063 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:11065 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
      HGNC:11064 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
      HGNC:11066 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:11058 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:1298205 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1337120 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
      MGI:1347355 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      MGI:1355323 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1858261 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:2142598 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:620639 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:619902 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
      RGD:619904 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621672 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:1309193 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
    Paralog (12)
    Structured_description: Concise_description: aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly. Paper_evidence: WBPaper00006408
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 02 Mar 2006 00:00:00
      Automated_description: Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Expressed in egg-laying apparatus; head motor neurons; and tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and lysinuric protein intolerance. Is an ortholog of human SLC7A8 (solute carrier family 7 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (26)
  Molecular_info: Corresponding_CDS: F27C8.1
    Corresponding_transcript: F27C8.1.1
    Other_sequence (63)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00087502 Inferred_automatically: RNAi_primary
      WBRNAi00045732 Inferred_automatically: RNAi_primary
      WBRNAi00031488 Inferred_automatically: RNAi_primary
      WBRNAi00113611 Inferred_automatically: RNAi_primary
      WBRNAi00013991 Inferred_automatically: RNAi_primary
      WBRNAi00112392 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1135
      Expr5887
      Expr15194
      Expr1023109
      Expr1030001
      Expr1149639
      Expr2009064
      Expr2027300
    Drives_construct: WBCnstr00003611
      WBCnstr00037804
      WBCnstr00042037
    Construct_product: WBCnstr00037804
      WBCnstr00042037
    Antibody: WBAntibody00000717
    Microarray_results (18)
    Expression_cluster (209)
    Interaction (13)
  Map_info: Map: IV Position: 4.33112 Error: 0.001998
    Positive: Positive_clone: F27C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006408
    WBPaper00024381
    WBPaper00035475
    WBPaper00038491
    WBPaper00042390
    WBPaper00045095
    WBPaper00050950
    WBPaper00053894
    WBPaper00055090
    WBPaper00060013
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene