T27F7.2 encodes three proteins by multiple splicing, two of which (T27F7.2A-B) are fully orthologous to vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like their orthologs, T27F7.2A-B have a PTB and an SH2 domain in N- to C-terminal order; T27F7.2 is expressed in gastrulating embryos (probably in neural precursors); T27F7.2 might be involved in RAS signal transduction or regulation of apoptosis.
Enriched in several structures, including ABalpapaap; excretory gland cell; g1; neurons; and somatic gonad precursor based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-2; hsf-1; and sir-2.1 based on RNA-seq and microarray studies. Is affected by eleven chemicals including 1-methylnicotinamide; Zidovudine; and Psoralens based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: SH2 domain superfamily and SH2 domain. Is an ortholog of human SH2D5 (SH2 domain containing 5).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.