WormBase Tree Display for Gene: WBGene00014215
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WBGene00014215 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | obr-3 | Person_evidence | WBPerson1105 | |||||
Sequence_name | ZK1086.1 | ||||||||
Molecular_name (6) | |||||||||
Other_name | CELE_ZK1086.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | obr-3 | ||||||||
DB_info | Database | AceView | gene | XO418 | |||||
WormQTL | gene | WBGene00014215 | |||||||
WormFlux | gene | WBGene00014215 | |||||||
NDB | locus_tag | CELE_ZK1086.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00014215|UniProtKB=Q8MPR9 | |||||||
family | PTHR10972 | ||||||||
NCBI | gene | 181495 | |||||||
RefSeq | protein | NM_001392877.1 | |||||||
NM_171794.7 | |||||||||
TREEFAM | TREEFAM_ID | TF312807 | |||||||
TrEMBL | UniProtAcc | Q8MPR9 | |||||||
G5EC19 | |||||||||
UniProt_GCRP | UniProtAcc | Q8MPR9 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 02 Jul 2004 16:55:45 | WBPerson1971 | Name_change | CGC_name | obr-3 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | obr | ||||||||
Allele (217) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (12) | |||||||||
Ortholog (37) | |||||||||
Paralog | WBGene00008832 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00012930 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00016331 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | obr-3 encodes two isoforms of a protein with an N-terminal pleckstrin domain and a C-terminal oxysterol-binding domain; OBR-3 has orthologs in Drosophila (CG5077) and humans (OSBPL8; OMIM:606736); OBR-3 binds the BMP receptor-associated molecule (BRAM) proteins BRA-1 and BRA-2; obr-3 is expressed in pharyngeal muscle, hypodermis, and several neurons; obr-3 is required for normally large body size, and the small body phenotype of obr-3(RNAi) animals is consistent with OBR-3 participating in TGF-beta signalling. | Paper_evidence | WBPaper00004823 | |||||
WBPaper00012885 | |||||||||
WBPaper00012937 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 08 Nov 2010 00:00:00 | ||||||||
Automated_description | Predicted to enable cholesterol binding activity and sterol transporter activity. Involved in regulation of growth and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and membrane. Expressed in hypodermis; neurons; and pharyngeal muscle cell. Is an ortholog of human OSBPL5 (oxysterol binding protein like 5) and OSBPL8 (oxysterol binding protein like 8). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | ZK1086.1a | |||||||
ZK1086.1b | |||||||||
Corresponding_CDS_history | ZK1086.1:wp83 | ||||||||
Corresponding_transcript | ZK1086.1a.1 | ||||||||
ZK1086.1b.1 | |||||||||
Other_sequence (19) | |||||||||
Associated_feature (15) | |||||||||
Experimental_info | RNAi_result (4) | ||||||||
Expr_pattern | Expr1629 | ||||||||
Expr1026177 | |||||||||
Expr1036370 | |||||||||
Expr1162528 | |||||||||
Expr2014593 | |||||||||
Expr2032826 | |||||||||
Drives_construct | WBCnstr00010358 | ||||||||
WBCnstr00029219 | |||||||||
Construct_product | WBCnstr00010358 | ||||||||
WBCnstr00029219 | |||||||||
Microarray_results (27) | |||||||||
Expression_cluster (123) | |||||||||
Interaction | WBInteraction000111256 | ||||||||
WBInteraction000222018 | |||||||||
WBInteraction000385708 | |||||||||
WBInteraction000403215 | |||||||||
WBInteraction000446791 | |||||||||
WBInteraction000449697 | |||||||||
WBInteraction000466421 | |||||||||
WBInteraction000541283 | |||||||||
WBInteraction000548958 | |||||||||
Map_info | Map | X | Position | 14.9473 | Error | 0.029025 | |||
Positive | Positive_clone | ZK1086 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4859 | |||||||
4827 | |||||||||
4961 | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00010145 | ||||||||
WBPaper00030935 | |||||||||
WBPaper00031972 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00053705 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00060493 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |