WormBase Tree Display for Gene: WBGene00007029

WBGene00007029 Evidence: Paper_evidence: WBPaper00013412
  SMap: S_parent: Sequence: VC5
  Identity: Version: 1
    Name: CGC_name: mys-1 Person_evidence: WBPerson268
      Sequence_name: VC5.4
      Molecular_name: VC5.4
        VC5.4.1
        CE21225
      Other_name: CELE_VC5.4 Accession_evidence: NDB BX284605
      Public_name: mys-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 19 May 2004 10:53:51 WBPerson1845 Event: Created
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mys
    Allele (46)
    Strain: WBStrain00027398
      WBStrain00027425
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (47)
    Paralog: WBGene00016200 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007914 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018013 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00045419 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010537 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mys-1 encodes a MYST family histone acetyltransferase orthologous to Drosophila EG0007.7, human TIP60, and S. cerevisiae Esa1p; during vulval development, mys-1 acts as Class C synMuv gene: mys-1 mutations enhance mutations in components of the C. elegans NuRD and Rb repressor complexes that negatively regulate expression of genes required for vulval induction; in addition, mys-1(RNAi) enhances mutations in pha-4, which encodes a FoxA transcription factor required for pharyngeal organogenesis; mys-1 mutations also cause a synthetic slow growth phenotype in combination with mutations in the MCD-1 zinc-finger protein; thus, mys-1 activity is essential for proper cell fate specification of different cell types at different times during C. elegans development. Paper_evidence: WBPaper00004587
            WBPaper00013412
            WBPaper00028549
            WBPaper00029005
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Jul 2007 00:00:00
      Automated_description: Predicted to enable histone H4K16 acetyltransferase activity and transcription coregulator activity. Involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of cell fate specification; and protein localization to chromatin. Predicted to be located in nucleus. Predicted to be part of MSL complex. Used to study obesity. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human KAT5 (lysine acetyltransferase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
    Potential_model: DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5275)
  Models_disease_in_annotation: WBDOannot00001260
  Molecular_info: Corresponding_CDS: VC5.4
    Corresponding_transcript: VC5.4.1
    Other_sequence (44)
    Associated_feature: WBsf652755
      WBsf1000424
      WBsf1019894
      WBsf233902
  Experimental_info: RNAi_result (49)
    Expr_pattern: Expr1014984
      Expr1033018
      Expr1158008
      Expr2013848
      Expr2032088
    Regulate_expr_cluster: WBPaper00050370:mys-1(RNAi)_L3_downregulated
      WBPaper00050370:mys-1(RNAi)_L3_upregulated
      WBPaper00064735:mys-1(RNAi)_vs_N2_downregulated
      WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated
    Antibody: WBAntibody00002720
    Microarray_results (19)
    Expression_cluster (99)
    Interaction (197)
    WBProcess: WBbiopr:00000071
      WBbiopr:00000072
      WBbiopr:00000073
  Map_info: Map: V Position: 0.546651 Error: 0.006496
    Positive: Positive_clone: VC5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4911
    Pseudo_map_position
  Reference (36)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene