WormBase Tree Display for Gene: WBGene00003003
expand all nodes | collapse all nodes | view schema
WBGene00003003 | SMap | S_parent | Sequence | T25C12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lin-14 | Person_evidence | WBPerson261 | |||||
Sequence_name | T25C12.1 | ||||||||
Molecular_name | T25C12.1a | ||||||||
T25C12.1a.1 | |||||||||
CE43285 | |||||||||
T25C12.1b | |||||||||
CE03734 | |||||||||
T25C12.1b.1 | |||||||||
Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lin-14 | ||||||||
DB_info | Database | AceView | gene | XM103 | |||||
WormQTL | gene | WBGene00003003 | |||||||
WormFlux | gene | WBGene00003003 | |||||||
NDB | locus_tag | CELE_T25C12.1 | |||||||
NCBI | gene | 181337 | |||||||
RefSeq | protein | NM_077515.5 | |||||||
NM_077516.7 | |||||||||
SwissProt | UniProtAcc | Q21446 | |||||||
TREEFAM | TREEFAM_ID | TF316913 | |||||||
UniProt_GCRP | UniProtAcc | Q21446 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lin | ||||||||
Reference_allele | WBVar00089301 | ||||||||
WBVar00089587 | |||||||||
Allele (337) | |||||||||
Legacy_information (3) | |||||||||
Strain (20) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (16) | |||||||||
Ortholog (28) | |||||||||
Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 | |||||
WBPaper00001137 | |||||||||
WBPaper00001468 | |||||||||
WBPaper00001829 | |||||||||
WBPaper00001848 | |||||||||
WBPaper00003931 | |||||||||
WBPaper00005159 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 02 Sep 2005 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | T25C12.1a | |||||||
T25C12.1b | |||||||||
Corresponding_CDS_history | T25C12.1a:wp196 | ||||||||
Corresponding_transcript | T25C12.1a.1 | ||||||||
T25C12.1b.1 | |||||||||
Other_sequence (11) | |||||||||
Associated_feature (55) | |||||||||
Transcription_factor | WBTranscriptionFactor000395 | ||||||||
Experimental_info | RNAi_result (17) | ||||||||
Expr_pattern (13) | |||||||||
Drives_construct | WBCnstr00000926 | ||||||||
WBCnstr00007336 | |||||||||
WBCnstr00007627 | |||||||||
WBCnstr00015030 | |||||||||
WBCnstr00015050 | |||||||||
WBCnstr00015780 | |||||||||
WBCnstr00015781 | |||||||||
WBCnstr00036292 | |||||||||
Construct_product (7) | |||||||||
Regulate_expr_cluster | WBPaper00026952:class_A | ||||||||
WBPaper00026952:class_B | |||||||||
WBPaper00026952:class_C | |||||||||
WBPaper00026952:class_D | |||||||||
WBPaper00026952:class_E | |||||||||
WBPaper00026952:class_F | |||||||||
WBPaper00026952:class_G | |||||||||
WBPaper00026952:class_H | |||||||||
Antibody | WBAntibody00000046 | ||||||||
WBAntibody00000337 | |||||||||
WBAntibody00000338 | |||||||||
WBAntibody00001031 | |||||||||
WBAntibody00001569 | |||||||||
WBAntibody00001873 | |||||||||
Microarray_results (33) | |||||||||
Expression_cluster (173) | |||||||||
Interaction (256) | |||||||||
WBProcess | WBbiopr:00000031 | ||||||||
WBbiopr:00000057 | |||||||||
WBbiopr:00000083 | |||||||||
Map_info (4) | |||||||||
Reference (365) | |||||||||
Method | Gene |