WormBase Tree Display for Gene: WBGene00000239
expand all nodes | collapse all nodes | view schema
WBGene00000239 | SMap | S_parent | Sequence | C05D2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | bas-1 | Person_evidence | WBPerson384 | |||||
Sequence_name | C05D2.4 | ||||||||
Molecular_name | C05D2.4a | ||||||||
C05D2.4a.1 | |||||||||
CE01141 | |||||||||
C05D2.4b | |||||||||
CE37081 | |||||||||
C05D2.4b.1 | |||||||||
Other_name | CELE_C05D2.4 | Accession_evidence | NDB | BX284603 | |||||
Public_name | bas-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | bas | ||||||||
Allele (42) | |||||||||
Legacy_information | [C.elegansII] ad446 : serotonin-deficient (nodetectable serotonin immunoreactivity);serotonin immunoreactivity restored by exposure to serotonin, but not to 5-hydroxytryptophan; poor male turning behavior [Loer and Kenyon 1993; LC; DA] | ||||||||
Strain | WBStrain00024110 | ||||||||
WBStrain00027310 | |||||||||
WBStrain00027351 | |||||||||
WBStrain00055166 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (44) | |||||||||
Paralog | WBGene00001839 | Caenorhabditis elegans | From_analysis (3) | ||||||
WBGene00006562 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00006409 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00015467 | Caenorhabditis elegans | From_analysis (3) | |||||||
WBGene00004981 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00006418 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00006762 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00007593 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00022427 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. | Paper_evidence | WBPaper00005551 | |||||
WBPaper00024422 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 25 Aug 2010 00:00:00 | ||||||||
Automated_description | Predicted to enable L-dopa decarboxylase activity. Involved in several processes, including locomotion involved in locomotory behavior; phenol-containing compound biosynthetic process; and reproductive behavior. Predicted to be located in cytoplasm. Expressed in dopaminergic neurons; serotonergic neurons; socket cell; tail; and in male. Used to study cocaine abuse and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and hyperinsulinism. Is an ortholog of human DDC (dopa decarboxylase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 May 2019 00:00:00 | ||||||||
DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00046053 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 23 May 2019 00:00:00 | ||||||||
Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | |||||
DOID:0090123 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
DOID:655 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
DOID:2018 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
Models_disease_asserted | WBDOannot00000678 | ||||||||
WBDOannot00000679 | |||||||||
WBDOannot00000680 | |||||||||
Molecular_info | Corresponding_CDS (2) | ||||||||
Corresponding_CDS_history | C05D2.4:wp127 | ||||||||
C05D2.4:wp135 | |||||||||
Corresponding_transcript | C05D2.4a.1 | ||||||||
C05D2.4b.1 | |||||||||
Other_sequence (45) | |||||||||
Associated_feature | WBsf047521 | ||||||||
WBsf047522 | |||||||||
WBsf645187 | |||||||||
WBsf654959 | |||||||||
WBsf992453 | |||||||||
WBsf992454 | |||||||||
WBsf224969 | |||||||||
Experimental_info | RNAi_result | WBRNAi00028502 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00039751 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00010206 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00005935 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066618 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00039752 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr3088 | ||||||||
Expr11668 | |||||||||
Expr15319 | |||||||||
Expr16107 | |||||||||
Expr1021971 | |||||||||
Expr1030153 | |||||||||
Expr1143843 | |||||||||
Expr2009531 | |||||||||
Expr2027768 | |||||||||
Drives_construct | WBCnstr00005610 | ||||||||
WBCnstr00011126 | |||||||||
WBCnstr00019307 | |||||||||
WBCnstr00037638 | |||||||||
WBCnstr00042765 | |||||||||
Construct_product (5) | |||||||||
Microarray_results (25) | |||||||||
Expression_cluster (189) | |||||||||
Interaction (47) | |||||||||
Map_info | Map | III | Position | -1.46925 | Error | 0.005315 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C05D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 2312 | |||||||
2693 | |||||||||
4332 | |||||||||
Reference (70) | |||||||||
Method | Gene |