WormBase Tree Display for Gene: WBGene00012532
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WBGene00012532 | SMap | S_parent | Sequence | Y32F6B | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | crp-1 | Paper_evidence | WBPaper00024905 | |||||
Sequence_name | Y32F6B.3 | ||||||||
Molecular_name | Y32F6B.3 | ||||||||
Y32F6B.3.1 | |||||||||
CE16612 | |||||||||
Other_name | CELE_Y32F6B.3 | Accession_evidence | NDB | BX284605 | |||||
Public_name | crp-1 | ||||||||
DB_info | Database | AceView | gene | 5K959 | |||||
WormQTL | gene | WBGene00012532 | |||||||
WormFlux | gene | WBGene00012532 | |||||||
NDB | locus_tag | CELE_Y32F6B.3 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00012532|UniProtKB=O62422 | |||||||
family | PTHR24072 | ||||||||
NCBI | gene | 179462 | |||||||
RefSeq | protein | NM_073287.7 | |||||||
TREEFAM | TREEFAM_ID | TF300837 | |||||||
TrEMBL | UniProtAcc | O62422 | |||||||
UniProt_GCRP | UniProtAcc | O62422 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 18 Feb 2005 12:07:44 | WBPerson2970 | Name_change | CGC_name | crp-1 | ||||
3 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303085 | ||||
Split_into | WBGene00303085 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | crp | ||||||||
Allele (32) | |||||||||
Strain | WBStrain00031568 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (14) | |||||||||
Ortholog (24) | |||||||||
Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00003239 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004287 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004357 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
Structured_description | Concise_description | crp-1 encodes a novel member of the Rho subfamily of Ras small GTP-binding proteins; genetic analyses indicate that CRP-1 functions in apical membrane trafficking events as well as in the DNA remodeling/transcriptional response that promotes adaptation to endoplasmic reticulum (ER) stress as part of the unfolded protein response (UPR); in regulating the UPR, CRP-1 likely functions together with the CDC-48.1 AAA+ ATPase and the HIM-6 RecQ helicase, with which it interacts in vitro; in C. elegans, a CRP-1::GFP fusion protein is first expressed in embryos in pharyngeal, rectal, and intestinal tissues; at later stage CRP-1::GFP expression is also seen in head and tail support cells (socket and sheath cells), the vulval epithelium, and the excretory cell; when expressed in NIH3T3 cells, CRP-1 localizes to the trans-Golgi network and to recycling endosomes and does not appear to affect actin cytoskeleton reorganization; in vitro assays indicate that CRP-1 is deficient in GTP hydrolysis, has a higher affinity for GDP (as opposed to GTP) binding, and exhibits low GDP-to-GTP nucleotide-exchange activity. | Paper_evidence | WBPaper00025137 | |||||
WBPaper00027071 | |||||||||
WBPaper00031857 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 09 Jan 2009 00:00:00 | ||||||||
Automated_description | Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Located in recycling endosome and trans-Golgi network. Expressed in several structures, including excretory cell; pharyngeal-intestinal valve; rectal epithelium; socket cell; and vulva. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | Y32F6B.3 | |||||||
Corresponding_CDS_history | Y32F6B.3a:wp264 | ||||||||
Y32F6B.3b:wp264 | |||||||||
Corresponding_transcript | Y32F6B.3.1 | ||||||||
Other_sequence (28) | |||||||||
Associated_feature | WBsf647160 | ||||||||
WBsf647161 | |||||||||
WBsf1001122 | |||||||||
WBsf1020314 | |||||||||
WBsf232385 | |||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern | Expr8631 | ||||||||
Expr8632 | |||||||||
Expr1021291 | |||||||||
Expr1035546 | |||||||||
Expr1159322 | |||||||||
Expr2010543 | |||||||||
Expr2028783 | |||||||||
Drives_construct | WBCnstr00013410 | ||||||||
WBCnstr00029919 | |||||||||
Construct_product (2) | |||||||||
Antibody | WBAntibody00001414 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (135) | |||||||||
Interaction (12) | |||||||||
WBProcess | WBbiopr:00000079 | ||||||||
Map_info | Map | V | Position | 2.56937 | Error | 0.00056 | |||
Positive | Positive_clone | Y32F6B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 5081 | |||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00004196 | ||||||||
WBPaper00025137 | |||||||||
WBPaper00027071 | |||||||||
WBPaper00027296 | |||||||||
WBPaper00029033 | |||||||||
WBPaper00031857 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00039146 | |||||||||
WBPaper00039975 | |||||||||
WBPaper00043290 | |||||||||
WBPaper00048842 | |||||||||
WBPaper00054187 | |||||||||
WBPaper00055090 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |