WormBase Tree Display for Gene: WBGene00004341

WBGene00004341 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F11H8
  Identity: Version: 1
    Name: CGC_name: rfl-1 Person_evidence: WBPerson75
      Sequence_name: F11H8.1
      Molecular_name (4)
      Other_name: uba-3 CGC_data_submission
        cyk-5
        CELE_F11H8.1 Accession_evidence: NDB BX284603
      Public_name: rfl-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rfl
    Allele (30)
    Legacy_information: [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. cytokinesis and spindle orientation defects
    Strain: WBStrain00003180
      WBStrain00003181
      WBStrain00007295
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (33)
    Paralog: WBGene00000142 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010882 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006699 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020184 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018357 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006735 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006700 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: rfl-1 encodes an ortholog of Uba3p, one subunit of a heterodimeric E1-activatingenzyme that also contains ULA-1 and functions in a Nedd8 ubiquitin-like protein conjugation pathway; RFL-1 activity is required for proper cytokinesis and spindle orientation. Paper_evidence: WBPaper00004449
            WBPaper00005108
            WBPaper00033469
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 06 Jan 2012 00:00:00
      Automated_description: Predicted to enable NEDD8 activating enzyme activity. Involved in negative regulation of DNA damage response, signal transduction by p53 class mediator and protein neddylation. Located in cytoplasm and nucleus. Expressed in head; tail; and vulval cell. Is an ortholog of human UBA3 (ubiquitin like modifier activating enzyme 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F11H8.1
    Corresponding_CDS_history: F11H8.1:wp102
    Corresponding_transcript: F11H8.1.1
      F11H8.1.2
    Other_sequence (72)
    Associated_feature: WBsf659156
      WBsf225192
  Experimental_info: RNAi_result (12)
    Expr_pattern: Chronogram9
      Chronogram1976
      Expr5744
      Expr8724
      Expr8732
      Expr1026976
      Expr1032159
      Expr1148365
      Expr2015308
      Expr2033542
    Drives_construct: WBCnstr00003656
      WBCnstr00003657
      WBCnstr00007592
      WBCnstr00013491
      WBCnstr00021674
      WBCnstr00035554
    Construct_product: WBCnstr00007586
      WBCnstr00007592
      WBCnstr00013482
      WBCnstr00013491
      WBCnstr00021673
      WBCnstr00021674
      WBCnstr00035554
    Microarray_results (22)
    Expression_cluster (93)
    Interaction (32)
  Map_info: Map: III Position: -0.846313 Error: 0.00498
    Positive: Positive_clone: F11H8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3854
        3859
  Reference: WBPaper00004363
    WBPaper00004449
    WBPaper00005108
    WBPaper00005262
    WBPaper00005337
    WBPaper00005914
    WBPaper00006054
    WBPaper00006085
    WBPaper00011527
    WBPaper00016952
    WBPaper00017727
    WBPaper00018925
    WBPaper00019271
    WBPaper00019705
    WBPaper00024507
    WBPaper00026118
    WBPaper00026631
    WBPaper00026821
    WBPaper00027991
    WBPaper00031384
    WBPaper00033119
    WBPaper00033469
    WBPaper00038491
    WBPaper00042729
    WBPaper00044012
    WBPaper00049964
    WBPaper00055090
  Remark: Sequence connection from [Kurz TK, Bowerman BA]
    Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb.
  Method: Gene