WormBase Tree Display for Gene: WBGene00000239
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| WBGene00000239 | SMap | S_parent | Sequence | C05D2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | bas-1 | Person_evidence | WBPerson384 | |||||
| Sequence_name | C05D2.4 | ||||||||
| Molecular_name | C05D2.4a | ||||||||
| C05D2.4a.1 | |||||||||
| CE01141 | |||||||||
| C05D2.4b | |||||||||
| CE37081 | |||||||||
| C05D2.4b.1 | |||||||||
| Other_name | CELE_C05D2.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | bas-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bas | ||||||||
| Allele (42) | |||||||||
| Legacy_information | [C.elegansII] ad446 : serotonin-deficient (nodetectable serotonin immunoreactivity);serotonin immunoreactivity restored by exposure to serotonin, but not to 5-hydroxytryptophan; poor male turning behavior [Loer and Kenyon 1993; LC; DA] | ||||||||
| Strain | WBStrain00024110 | ||||||||
| WBStrain00027310 | |||||||||
| WBStrain00027351 | |||||||||
| WBStrain00055166 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00001839 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006562 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006409 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015467 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004981 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006418 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006762 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007593 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022427 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. | Paper_evidence | WBPaper00005551 | |||||
| WBPaper00024422 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Aug 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable L-dopa decarboxylase activity. Involved in several processes, including locomotion involved in locomotory behavior; phenol-containing compound biosynthetic process; and reproductive behavior. Predicted to be located in cytoplasm. Expressed in dopaminergic neurons; serotonergic neurons; socket cell; tail; and in male. Used to study cocaine abuse and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and hyperinsulinism. Is an ortholog of human DDC (dopa decarboxylase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 May 2019 00:00:00 | ||||||||
| DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00046053 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 May 2019 00:00:00 | ||||||||
| Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | |||||
| DOID:0090123 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| DOID:655 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| DOID:2018 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| Models_disease_asserted | WBDOannot00000678 | ||||||||
| WBDOannot00000679 | |||||||||
| WBDOannot00000680 | |||||||||
| Molecular_info (5) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028502 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00039751 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010206 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005935 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066618 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039752 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3088 | ||||||||
| Expr11668 | |||||||||
| Expr15319 | |||||||||
| Expr16107 | |||||||||
| Expr1021971 | |||||||||
| Expr1030153 | |||||||||
| Expr1143843 | |||||||||
| Expr2009531 | |||||||||
| Expr2027768 | |||||||||
| Drives_construct | WBCnstr00005610 | ||||||||
| WBCnstr00011126 | |||||||||
| WBCnstr00019307 | |||||||||
| WBCnstr00037638 | |||||||||
| WBCnstr00042765 | |||||||||
| Construct_product | WBCnstr00011126 | ||||||||
| WBCnstr00019307 | |||||||||
| WBCnstr00037638 | |||||||||
| WBCnstr00040178 | |||||||||
| WBCnstr00040179 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (188) | |||||||||
| Interaction (47) | |||||||||
| Map_info | Map | III | Position | -1.46925 | Error | 0.005315 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C05D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 2312 | |||||||
| 2693 | |||||||||
| 4332 | |||||||||
| Reference | WBPaper00001861 | ||||||||
| WBPaper00002320 | |||||||||
| WBPaper00004195 | |||||||||
| WBPaper00004257 | |||||||||
| WBPaper00004653 | |||||||||
| WBPaper00005274 | |||||||||
| WBPaper00005551 | |||||||||
| WBPaper00005734 | |||||||||
| WBPaper00005977 | |||||||||
| WBPaper00006045 | |||||||||
| WBPaper00006272 | |||||||||
| WBPaper00011911 | |||||||||
| WBPaper00015782 | |||||||||
| WBPaper00016742 | |||||||||
| WBPaper00016920 | |||||||||
| WBPaper00016925 | |||||||||
| WBPaper00017338 | |||||||||
| WBPaper00017417 | |||||||||
| WBPaper00017787 | |||||||||
| WBPaper00019250 | |||||||||
| WBPaper00023396 | |||||||||
| WBPaper00023952 | |||||||||
| WBPaper00024422 | |||||||||
| WBPaper00025146 | |||||||||
| WBPaper00026785 | |||||||||
| WBPaper00026835 | |||||||||
| WBPaper00026981 | |||||||||
| WBPaper00027661 | |||||||||
| WBPaper00029013 | |||||||||
| WBPaper00029029 | |||||||||
| WBPaper00029150 | |||||||||
| WBPaper00030285 | |||||||||
| WBPaper00030761 | |||||||||
| WBPaper00030837 | |||||||||
| WBPaper00031936 | |||||||||
| WBPaper00032335 | |||||||||
| WBPaper00032852 | |||||||||
| WBPaper00032994 | |||||||||
| WBPaper00034171 | |||||||||
| WBPaper00036750 | |||||||||
| WBPaper00037844 | |||||||||
| WBPaper00038382 | |||||||||
| WBPaper00040158 | |||||||||
| WBPaper00040570 | |||||||||
| WBPaper00043549 | |||||||||
| WBPaper00043610 | |||||||||
| WBPaper00043908 | |||||||||
| WBPaper00044142 | |||||||||
| WBPaper00044457 | |||||||||
| WBPaper00044757 | |||||||||
| WBPaper00044984 | |||||||||
| WBPaper00046053 | |||||||||
| WBPaper00046585 | |||||||||
| WBPaper00047870 | |||||||||
| WBPaper00047934 | |||||||||
| WBPaper00048034 | |||||||||
| WBPaper00048770 | |||||||||
| WBPaper00052716 | |||||||||
| WBPaper00052851 | |||||||||
| WBPaper00053123 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00058451 | |||||||||
| WBPaper00058949 | |||||||||
| WBPaper00059495 | |||||||||
| WBPaper00060921 | |||||||||
| WBPaper00061641 | |||||||||
| WBPaper00065140 | |||||||||
| WBPaper00065331 | |||||||||
| WBPaper00066097 | |||||||||
| Method | Gene |
