WormBase Tree Display for Gene: WBGene00001137

WBGene00001137 SMap: S_parent: Sequence: B0365
  Identity: Version: 1
    Name: CGC_name: eat-6 Person_evidence: WBPerson32
      Sequence_name: B0365.3
      Molecular_name: B0365.3
        B0365.3.1
        CE07721
        B0365.3.2
      Other_name: NaK/1
        spa-1
        CELE_B0365.3 Accession_evidence: NDB BX284605
      Public_name: eat-6
    DB_info: Database: AceView gene 5N608
        WormQTL gene WBGene00001137
        WormFlux gene WBGene00001137
        NDB locus_tag CELE_B0365.3
        Panther gene CAEEL|WormBase=WBGene00001137|UniProtKB=P90735
          family PTHR43294
        NCBI gene 179796
        RefSeq protein NM_073868.6
        TrEMBL UniProtAcc P90735
        UniProt_GCRP UniProtAcc P90735
        OMIM gene 182310
            182340
            182350
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eat
    Allele (46)
    Legacy_information: [Leon Avery] Strong relaxation-defective. Pharynx oftens fails to relax, or relaxes slowly. There are long yawns, where the corpus stays open for seconds, punctuated with erratic partial relaxations. The terminal bulb is usually more strongly affected than the corpus, but the motions of the two are precisely synchronized. Relaxation transient is reduced in size in electropharyngeograms.
      See also ad601, ad792
      [C.elegansII] ad467 : strong relaxation-defective.Pharynx oftens fails to relax, or relaxes slowly. There are long yawns, where the corpus stays open for seconds, punctuated with erratic partial relaxations. The terminal bulb is usually more strongly affected than the corpus, but the motions of the two are precisely synchronized. Relaxation transient is reduced in size in electropharyngeograms. Hypersensitive to inhibitors of Na/K ATPase. Synthetic lethal with eat-11(ad541).OA2: ad601xri, ad792. Cloned: encodes alpha subunit of Na/K ATPase (pka spa-1). [Avery 1993; DA]
    Strain: WBStrain00036106
      WBStrain00037778
      WBStrain00005464
      WBStrain00005489
      WBStrain00005507
      WBStrain00005516
      WBStrain00005529
    RNASeq_FPKM (74)
    GO_annotation (36)
    Ortholog (46)
    Paralog: WBGene00015338 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015660 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013672 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007248 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000834 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003151 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003153 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004063 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004736 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00007514 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012341 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019493 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019875 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022010 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. Paper_evidence: WBPaper00001709
            WBPaper00002371
            WBPaper00003150
            WBPaper00003257
            WBPaper00003521
          Curator_confirmed: WBPerson48
            WBPerson363
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including action potential; monoatomic ion transport; and regulation of muscle contraction. Located in membrane. Expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; and brain disease (multiple). Is an ortholog of human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00045914
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jun 2019 00:00:00
    Potential_model (12)
  Models_disease_asserted: WBDOannot00000704
  Molecular_info: Corresponding_CDS: B0365.3
    Corresponding_transcript: B0365.3.1
      B0365.3.2
    Other_sequence: XI04354
      XIC01037_1
      EX011827.1
      FK809067.1
      XI02215
      GR13800
      GR19194
      JI212697.1
      ACC11763_1
      FC550079.1
      BU087608.1
      Oden_isotig02033
      CGC00503_1
      MI00432
      CJC04788_1
      FK809640.1
      FK805715.1
      EX545665.1
      EX556794.1
      AE04917
      FK808388.1
      Oden_isotig02035
      Tcol_isotig17605
      FC820357.1
      ES741918.1
      FC817595.1
      XIC04102_1
      FD515645.1
      FK801717.1
      MC02919
      FK804444.1
      Acan_isotig11856
      FK807099.1
      BXC06386_1
      FC810483.1
      CJC09717_1
      HBC01019_1
      FK804618.1
      MA01476
      CBC07764_1
      DAC02214_1
      SSC02850_1
      PTC00704_1
      MAC00783_1
      JO474372.1
      EY466874.1
      SS01028
      JI167158.1
      FC818264.1
      RSC02643_1
      EX551775.1
      AS11179
      JI164820.1
      Acan_isotig22234
      FC814245.1
      FC814716.1
      EX916067.1
      FC547137.1
      GRC00308_1
      PSC03795_1
      FC810346.1
      CRC03832_1
      FK801809.1
      BU666570.1
      FC541445.1
      XI00768
      FK805875.1
      Oden_isotig02034
      FK803237.1
      FC811993.1
      Oden_isotig02039
      MH07257
      RSC03187_1
      EY459068.1
      FK809438.1
      EY473421.1
      DA04845
      ES411321.1
      MI02442
      TX01593
      FK802218.1
      JI166042.1
      FK804223.1
      ES409011.1
      FG980297.1
      FG975072.1
      BXC04848_1
      DAC01639_1
      Tcol_isotig06599
      SR00700
      Name_isotig01786
      EX014365.1
      FK807485.1
      DA05985
      EX910807.1
      FG974733.1
      AY740513.1
      SR02517
      EY470479.1
      TMC00052_1
      Hbac_isotig04119
      FK806236.1
      BI773204.1
      FG588343.1
      FF679066.1
      PP00800
      FK807294.1
      BU086627.1
      Hbac_isotig01137
      EY461238.1
      CJC06021_1
      GR10418
      Dviv_isotig11836
      JI215313.1
      CBC00517_1
      FK802261.1
      PPC08448_1
      GO251444.1
      EX913405.1
      AS01815
      MI04135
      MCC01190_1
      DN153369.1
      FK808940.1
      FK801880.1
      HS00207
      TCC01563_1
      GRC03043_1
      SSC02659_1
      Oden_isotig02041
      EX562811.1
      PVC02760_1
      SSC03936_1
      Oden_isotig02037
      FG971484.1
      HSC00671_1
      ACC27601_1
      Tcol_isotig15305
      BU086855.1
      FC555168.1
      EX828185.1
      FC811055.1
      FF678176.1
      FG348713.1
      JO471255.1
      MCC02226_1
      HG00254
      FC817022.1
      FK801617.1
      FK805796.1
      Oden_isotig02028
      Hbac_isotig06939
      Oden_isotig02040
      MIC01012_1
      CRC10966_1
      FC820289.1
      PPC01232_1
      CSC01283_1
      RS07425
      EY464855.1
      Oden_isotig17871
      FC543998.1
      Oden_isotig02029
      EY462038.1
      EX012366.1
      BXC00573_1
      EX556901.1
      EX009059.1
      HG12107
      BXC07568_1
      FC815739.1
      HG04654
      FK801555.1
      SSC01672_1
      JI219823.1
      FC815900.1
      SR02159
      SRC00687_1
      SSC03684_1
      CR02150
      ES743737.1
      BXC01222_1
      SR04922
      FK802754.1
      RS09261
      XIC04360_1
      FK809496.1
      SS01525
      Oden_isotig17713
      CR06569
      FK809059.1
      PPC10144_1
      ASC02824_1
      FF678889.1
      FK808719.1
      FC816530.1
      FC809431.1
      ES739732.1
      BU088521.1
      MC02525
      BMC06636_1
      SSC03128_1
      EX010908.1
      Oden_isotig02036
      FC547736.1
      Tcol_isotig06597
      Name_isotig04720
      Dviv_isotig11834
      MH01042
      PPC04942_1
      FK799984.1
      HGC10027_1
      EL888478.1
      JI243810.1
      PT00636
      FG975612.1
      BXC04920_1
      XI03682
      Oden_isotig02030
      OOC03635_1
      FG978694.1
      FK809798.1
      XI05230
      EX542212.1
      HBC01410_1
      Oden_isotig02032
      NAC01814_1
      MI00952
      SR00308
      FC547211.1
      FC812612.1
      ACC10692_1
      FK803355.1
      FK803468.1
      FK807085.1
      NAC01104_1
      ES410442.1
      AYC04013_1
      BXC05226_1
      SSC01079_1
      FG976774.1
      FK807514.1
      JI165174.1
      FK800390.1
      Acan_isotig07790
      FK809808.1
      Oden_isotig02031
      Oden_isotig02038
      Tcol_isotig06598
      FC539304.1
      MIC00151_1
      CSC00375_1
      Oden_isotig02027
      JI182764.1
      FC811484.1
      EX554334.1
      ES742206.1
      Oden_isotig17870
      AS10883
      FK804943.1
      XIC01382_1
      XIC04825_1
      MI00525
      FG974802.1
      SRC00687_2
      FD516042.1
      Dviv_isotig11835
      EY473807.1
      FC546764.1
      MHC01413_1
      FK802954.1
      GW407330.1
      CGC01491_1
      FK806355.1
      JI165276.1
      Acan_isotig12038
    Associated_feature (18)
  Experimental_info: RNAi_result (34)
    Expr_pattern: Expr8226
      Expr8228
      Expr12845
      Expr1017676
      Expr1030726
      Expr1143152
      Expr2011160
      Expr2029396
    Drives_construct: WBCnstr00013194
      WBCnstr00022897
      WBCnstr00037068
    Construct_product: WBCnstr00013192
      WBCnstr00037068
    Microarray_results (26)
    Expression_cluster (174)
    Interaction (116)
  Map_info: Map: V Position: 4.93766 Error: 0.013547
    Well_ordered
    Positive: Positive_clone: B0365 Inferred_automatically: From sequence, transcript, pseudogene data
        DF#NK1
        R07B8
    Mapping_data: 2_point: 5213
      Multi_point: 1837
        1839
        1840
        1841
        2403
        2404
        3844
        4482
      Pos_neg_data: 5212
        5214
        5215
        7050
  Reference (55)
  Remark: [MW Davis] Transformation rescue.
  Method: Gene