WormBase Tree Display for Gene: WBGene00019875
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| WBGene00019875 | SMap | S_parent | Sequence | R05C11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mca-2 | |||||||
| Sequence_name | R05C11.3 | ||||||||
| Molecular_name | R05C11.3 | ||||||||
| R05C11.3.1 | |||||||||
| CE28747 | |||||||||
| Other_name | CELE_R05C11.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | mca-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 05 Feb 2009 12:16:59 | WBPerson2970 | Event | Acquires_merge | WBGene00003152 | ||||
| Name_change | CGC_name | mca-2 | |||||||
| Acquires_merge | WBGene00003152 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mca | ||||||||
| Allele (137) | |||||||||
| Legacy_information | [Kraev A] mca for Membrane Calcium ATPase. No mutants known. See mca-1. | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (52) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | mca-2 encodes a calcium-transporting ATPase; large-scale RNAi screens indicate that mca-2 activity is required for locomotion and normal rates of postembryonic growth. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00006395 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable P-type calcium transporter activity. Predicted to be involved in regulation of cytosolic calcium ion concentration. Predicted to be located in intracellular membrane-bounded organelle. Expressed in hypodermis. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; and nonsyndromic deafness (multiple). Is an ortholog of several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814) | ||||
| DOID:0111829 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:816) | ||||||
| DOID:0050564 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
| DOID:0110467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
| DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
| Molecular_info | Corresponding_CDS | R05C11.3 | |||||||
| Corresponding_transcript | R05C11.3.1 | ||||||||
| Other_sequence (62) | |||||||||
| Associated_feature | WBsf659962 | ||||||||
| WBsf995618 | |||||||||
| WBsf995619 | |||||||||
| WBsf995620 | |||||||||
| WBsf995621 | |||||||||
| WBsf1016855 | |||||||||
| WBsf1016856 | |||||||||
| WBsf1016857 | |||||||||
| WBsf1016858 | |||||||||
| WBsf227999 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00051265 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027426 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026020 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066745 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066559 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017425 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8319 | ||||||||
| Expr1013470 | |||||||||
| Expr1038621 | |||||||||
| Expr1154966 | |||||||||
| Expr2013443 | |||||||||
| Expr2031677 | |||||||||
| Drives_construct | WBCnstr00008392 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | IV | Position | -11.4549 | Error | 0.132104 | |||
| Positive | Positive_clone | R05C11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003407 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
