WormBase Tree Display for Gene: WBGene00003151
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| WBGene00003151 | SMap | S_parent | Sequence | W09C2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mca-1 | |||||||
| Sequence_name | W09C2.3 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_W09C2.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | mca-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mca | ||||||||
| Allele (95) | |||||||||
| Legacy_information | [Kraev A] Originally identified by similarity to mammalian PMCA family proteins in Genome Project data, mca-1 was expressed in insect cells and shown to have the predicted activity: aspartyl-phosphate formation in the presence of calcium, like mammalian counterparts, has a calmodulin-binding domain at the C-terminus and actually binds human calmodulin in a standard assay. Two other related sequences identified in the genomic sequencing data "in progress" and cDNAs finished by direct RT-PCR product sequencing. Mca-3 shows the highest sequence similarity to the mammalian analogues (77% on aminoacid). All three mca sequences have calmodulin-binding domains at the same location as their mammalian counterparts and the same predicted trans-membrane topology | ||||||||
| Strain | WBStrain00037024 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (40) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | mca-1 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-1 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; when expressed in insect cells, MCA-1 exhibits calcium-pumping ATPase activity and binding to human calmodulin; large-scale RNAi screens indicate that mca-1 activity is required for normal coordinated locomotion and rates of growth; an mca-1::gfp reporter fusion is expressed solely in the excretory canal. | Paper_evidence | WBPaper00003407 | |||||
| WBPaper00029172 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Apr 2007 00:00:00 | ||||||||
| Automated_description | Enables P-type calcium transporter activity and calmodulin binding activity. Involved in calcium ion transport and intracellular calcium ion homeostasis. Located in membrane. Expressed in excretory canal. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W09C2.3a | |||||||
| W09C2.3b | |||||||||
| W09C2.3c | |||||||||
| W09C2.3d | |||||||||
| Corresponding_CDS_history | W09C2.3:wp92 | ||||||||
| Corresponding_transcript | W09C2.3a.1 | ||||||||
| W09C2.3b.1 | |||||||||
| W09C2.3c.1 | |||||||||
| W09C2.3d.1 | |||||||||
| Other_sequence (51) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00088616 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00026522 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019742 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000551 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00088723 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055018 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027503 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026523 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8318 | ||||||||
| Expr1025870 | |||||||||
| Expr1031487 | |||||||||
| Expr1158554 | |||||||||
| Expr2013442 | |||||||||
| Expr2031676 | |||||||||
| Drives_construct | WBCnstr00008393 | ||||||||
| WBCnstr00013258 | |||||||||
| WBCnstr00036215 | |||||||||
| Construct_product | WBCnstr00036215 | ||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (72) | |||||||||
| Map_info | Map | IV | Position | 4.34306 | Error | 0.000339 | |||
| Positive | Positive_clone | W09C2 | Author_evidence | Kraev A | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003407 | ||||||||
| WBPaper00011802 | |||||||||
| WBPaper00015567 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
