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WormBase Tree Display for Gene: WBGene00012532

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Name Class

WBGene00012532SMapS_parentSequenceY32F6B
IdentityVersion3
NameCGC_namecrp-1Paper_evidenceWBPaper00024905
Sequence_nameY32F6B.3
Molecular_nameY32F6B.3
Y32F6B.3.1
CE16612
Other_nameCELE_Y32F6B.3Accession_evidenceNDBBX284605
Public_namecrp-1
DB_infoDatabaseAceViewgene5K959
WormQTLgeneWBGene00012532
WormFluxgeneWBGene00012532
NDBlocus_tagCELE_Y32F6B.3
PanthergeneCAEEL|WormBase=WBGene00012532|UniProtKB=O62422
familyPTHR24072
NCBIgene179462
RefSeqproteinNM_073287.7
TREEFAMTREEFAM_IDTF300837
TrEMBLUniProtAccO62422
UniProt_GCRPUniProtAccO62422
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
218 Feb 2005 12:07:44WBPerson2970Name_changeCGC_namecrp-1
302 Mar 2018 11:09:16WBPerson4025EventSplit_intoWBGene00303085
Split_intoWBGene00303085
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcrp
Allele (32)
StrainWBStrain00031568
RNASeq_FPKM (74)
GO_annotation (14)
OrthologWBGene00065063Caenorhabditis remaneiFrom_analysis (4)
WBGene00031162Caenorhabditis briggsaeFrom_analysis (5)
WBGene00184995Caenorhabditis brenneriFrom_analysis (4)
WBGene00134945Caenorhabditis japonicaFrom_analysis (2)
CSP21.g1443Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g281Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g22220Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g17669Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP29.g5911Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g18457Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g12577Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g15493Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g11567Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g2216Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00242.g7714Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-crp-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g15495Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00907.g16647Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_11765Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_016414Caenorhabditis remaneiFrom_analysisWormBase-Compara
Pan_g13703Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_50292710Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrV_pilon.g15530Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00108581Pristionchus pacificusFrom_analysisWormBase-Compara
ParalogWBGene00000390Caenorhabditis elegansFrom_analysis (2)
WBGene00000424Caenorhabditis elegansFrom_analysis (2)
WBGene00003239Caenorhabditis elegansFrom_analysis (2)
WBGene00004287Caenorhabditis elegansFrom_analysis (2)
WBGene00004357Caenorhabditis elegansFrom_analysis (3)
WBGene00009059Caenorhabditis elegansFrom_analysis (2)
WBGene00019544Caenorhabditis elegansFrom_analysis (2)
WBGene00022177Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptioncrp-1 encodes a novel member of the Rho subfamily of Ras small GTP-binding proteins; genetic analyses indicate that CRP-1 functions in apical membrane trafficking events as well as in the DNA remodeling/transcriptional response that promotes adaptation to endoplasmic reticulum (ER) stress as part of the unfolded protein response (UPR); in regulating the UPR, CRP-1 likely functions together with the CDC-48.1 AAA+ ATPase and the HIM-6 RecQ helicase, with which it interacts in vitro; in C. elegans, a CRP-1::GFP fusion protein is first expressed in embryos in pharyngeal, rectal, and intestinal tissues; at later stage CRP-1::GFP expression is also seen in head and tail support cells (socket and sheath cells), the vulval epithelium, and the excretory cell; when expressed in NIH3T3 cells, CRP-1 localizes to the trans-Golgi network and to recycling endosomes and does not appear to affect actin cytoskeleton reorganization; in vitro assays indicate that CRP-1 is deficient in GTP hydrolysis, has a higher affinity for GDP (as opposed to GTP) binding, and exhibits low GDP-to-GTP nucleotide-exchange activity.Paper_evidenceWBPaper00025137
WBPaper00027071
WBPaper00031857
Curator_confirmedWBPerson1843
Date_last_updated09 Jan 2009 00:00:00
Automated_descriptionPredicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Located in recycling endosome and trans-Golgi network. Expressed in several structures, including excretory cell; pharyngeal-intestinal valve; rectal epithelium; socket cell; and vulva.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSY32F6B.3
Corresponding_CDS_historyY32F6B.3a:wp264
Y32F6B.3b:wp264
Corresponding_transcriptY32F6B.3.1
Other_sequence (28)
Associated_featureWBsf647160
WBsf647161
WBsf1001122
WBsf1020314
WBsf232385
Experimental_infoRNAi_result (11)
Expr_patternExpr8631
Expr8632
Expr1021291
Expr1035546
Expr1159322
Expr2010543
Expr2028783
Drives_constructWBCnstr00013410
WBCnstr00029919
Construct_productWBCnstr00013410
WBCnstr00029919
AntibodyWBAntibody00001414
Microarray_results (20)
Expression_cluster (135)
Interaction (12)
WBProcessWBbiopr:00000079
Map_infoMapVPosition2.56937Error0.00056
PositivePositive_cloneY32F6BInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5081
Pseudo_map_position
Reference (13)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene