WormBase Tree Display for Gene: WBGene00000239
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WBGene00000239 | SMap | S_parent | Sequence | C05D2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | bas | ||||||
Allele (42) | |||||||
Legacy_information | [C.elegansII] ad446 : serotonin-deficient (nodetectable serotonin immunoreactivity);serotonin immunoreactivity restored by exposure to serotonin, but not to 5-hydroxytryptophan; poor male turning behavior [Loer and Kenyon 1993; LC; DA] | ||||||
Strain | WBStrain00024110 | ||||||
WBStrain00027310 | |||||||
WBStrain00027351 | |||||||
WBStrain00055166 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (44) | |||||||
Paralog | WBGene00001839 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00006562 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00006409 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00015467 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00004981 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006418 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006762 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00007593 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00022427 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. | Paper_evidence | WBPaper00005551 | |||
WBPaper00024422 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 25 Aug 2010 00:00:00 | ||||||
Automated_description | Predicted to enable L-dopa decarboxylase activity. Involved in several processes, including locomotion involved in locomotory behavior; phenol-containing compound biosynthetic process; and reproductive behavior. Predicted to be located in cytoplasm. Expressed in dopaminergic neurons; serotonergic neurons; socket cell; tail; and in male. Used to study cocaine abuse and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and hyperinsulinism. Is an ortholog of human DDC (dopa decarboxylase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 May 2019 00:00:00 | ||||||
DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00046053 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 23 May 2019 00:00:00 | ||||||
Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | |||
DOID:0090123 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||
DOID:655 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||
DOID:2018 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||
Models_disease_asserted | WBDOannot00000678 | ||||||
WBDOannot00000679 | |||||||
WBDOannot00000680 | |||||||
Molecular_info | Corresponding_CDS | C05D2.4a | |||||
C05D2.4b | |||||||
Corresponding_CDS_history | C05D2.4:wp127 | ||||||
C05D2.4:wp135 | |||||||
Corresponding_transcript | C05D2.4a.1 | ||||||
C05D2.4b.1 | |||||||
Other_sequence (45) | |||||||
Associated_feature | WBsf047521 | ||||||
WBsf047522 | |||||||
WBsf645187 | |||||||
WBsf654959 | |||||||
WBsf992453 | |||||||
WBsf992454 | |||||||
WBsf224969 | |||||||
Experimental_info | RNAi_result | WBRNAi00028502 | Inferred_automatically | RNAi_primary | |||
WBRNAi00039751 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00010206 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005935 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00066618 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00039752 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr3088 | ||||||
Expr11668 | |||||||
Expr15319 | |||||||
Expr16107 | |||||||
Expr1021971 | |||||||
Expr1030153 | |||||||
Expr1143843 | |||||||
Expr2009531 | |||||||
Expr2027768 | |||||||
Drives_construct | WBCnstr00005610 | ||||||
WBCnstr00011126 | |||||||
WBCnstr00019307 | |||||||
WBCnstr00037638 | |||||||
WBCnstr00042765 | |||||||
Construct_product | WBCnstr00011126 | ||||||
WBCnstr00019307 | |||||||
WBCnstr00037638 | |||||||
WBCnstr00040178 | |||||||
WBCnstr00040179 | |||||||
Microarray_results | SMD_C05D2.4 | ||||||
192695_at | |||||||
A_12_P115723 | |||||||
A_12_P134875 | |||||||
A_12_P134876 | |||||||
Aff_C05D2.4 | |||||||
GPL13394_WBGene00000239 | |||||||
GPL13914_C05D2.4 | |||||||
GPL14144_C05D2.4b_1059-1118_0.917_15_C | |||||||
GPL14144_C05D2.4b_1101-1160_0.930_7_B | |||||||
GPL14144_C05D2.4b_1326-1385_0.911_20_A | |||||||
GPL19516_CGZ0002618 | |||||||
GPL19516_CGZ0002619 | |||||||
GPL21109_C05D2.4a | |||||||
GPL3518_CE01141 | |||||||
GPL8304_CE_WBGene00000239_A | |||||||
GPL8304_CE_WBGene00000239_B | |||||||
GPL8673_C05D2_4aP00179 | |||||||
GPL8673_C05D2_4aP00452 | |||||||
GPL8673_C05D2_4aP01229 | |||||||
GPL8673_C05D2_4bP00179 | |||||||
GPL8673_C05D2_4bP00575 | |||||||
GPL8673_C05D2_4bP01256 | |||||||
GPL9450_C05D2.4 | |||||||
cea2.p.56056 | |||||||
Expression_cluster (188) | |||||||
Interaction (47) | |||||||
Map_info | Map | III | Position | -1.46925 | Error | 0.005315 | |
Well_ordered | |||||||
Positive | Positive_clone | C05D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 2312 | |||||
2693 | |||||||
4332 | |||||||
Reference (69) | |||||||
Method | Gene |