rfl-1 encodes an ortholog of Uba3p, one subunit of a heterodimeric E1-activatingenzyme that also contains ULA-1 and functions in a Nedd8 ubiquitin-like protein conjugation pathway; RFL-1 activity is required for proper cytokinesis and spindle orientation.
Predicted to enable NEDD8 activating enzyme activity. Involved in negative regulation of DNA damage response, signal transduction by p53 class mediator and protein neddylation. Located in cytoplasm and nucleus. Expressed in head; tail; and vulval cell. Is an ortholog of human UBA3 (ubiquitin like modifier activating enzyme 3).