WormBase Tree Display for Gene: WBGene00000239

WBGene00000239 SMap: S_parent: Sequence: C05D2
  Identity: Version: 1
    Name: CGC_name: bas-1 Person_evidence: WBPerson384
      Sequence_name: C05D2.4
      Molecular_name: C05D2.4a
        C05D2.4a.1
        CE01141
        C05D2.4b
        CE37081
        C05D2.4b.1
      Other_name: CELE_C05D2.4 Accession_evidence: NDB BX284603
      Public_name: bas-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bas
    Allele (42)
    Legacy_information: [C.elegansII] ad446 : serotonin-deficient (nodetectable serotonin immunoreactivity);serotonin immunoreactivity restored by exposure to serotonin, but not to 5-hydroxytryptophan; poor male turning behavior [Loer and Kenyon 1993; LC; DA]
    Strain: WBStrain00024110
      WBStrain00027310
      WBStrain00027351
      WBStrain00055166
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (44)
    Paralog: WBGene00001839 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006562 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00006409 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015467 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004981 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006418 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006762 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00007593 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022427 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. Paper_evidence: WBPaper00005551
            WBPaper00024422
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 25 Aug 2010 00:00:00
      Automated_description: Predicted to enable L-dopa decarboxylase activity. Involved in several processes, including locomotion involved in locomotory behavior; phenol-containing compound biosynthetic process; and reproductive behavior. Predicted to be located in cytoplasm. Expressed in dopaminergic neurons; serotonergic neurons; socket cell; tail; and in male. Used to study cocaine abuse and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and hyperinsulinism. Is an ortholog of human DDC (dopa decarboxylase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:809 Homo sapiens Paper_evidence: WBPaper00034643
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 May 2019 00:00:00
      DOID:0050742 Homo sapiens Paper_evidence: WBPaper00046053
          Curator_confirmed: WBPerson324
          Date_last_updated: 23 May 2019 00:00:00
    Potential_model: DOID:3312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:0090123 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:655 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:2018 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
  Models_disease_asserted: WBDOannot00000678
    WBDOannot00000679
    WBDOannot00000680
  Molecular_info: Corresponding_CDS (2)
    Corresponding_CDS_history: C05D2.4:wp127
      C05D2.4:wp135
    Corresponding_transcript: C05D2.4a.1
      C05D2.4b.1
    Other_sequence (45)
    Associated_feature: WBsf047521
      WBsf047522
      WBsf645187
      WBsf654959
      WBsf992453
      WBsf992454
      WBsf224969
  Experimental_info: RNAi_result: WBRNAi00028502 Inferred_automatically: RNAi_primary
      WBRNAi00039751 Inferred_automatically: RNAi_primary
      WBRNAi00010206 Inferred_automatically: RNAi_primary
      WBRNAi00005935 Inferred_automatically: RNAi_primary
      WBRNAi00066618 Inferred_automatically: RNAi_primary
      WBRNAi00039752 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3088
      Expr11668
      Expr15319
      Expr16107
      Expr1021971
      Expr1030153
      Expr1143843
      Expr2009531
      Expr2027768
    Drives_construct: WBCnstr00005610
      WBCnstr00011126
      WBCnstr00019307
      WBCnstr00037638
      WBCnstr00042765
    Construct_product: WBCnstr00011126
      WBCnstr00019307
      WBCnstr00037638
      WBCnstr00040178
      WBCnstr00040179
    Microarray_results (25)
    Expression_cluster (188)
    Interaction: WBInteraction000029976
      WBInteraction000145279
      WBInteraction000183103
      WBInteraction000192056
      WBInteraction000194210
      WBInteraction000202905
      WBInteraction000211047
      WBInteraction000214494
      WBInteraction000215371
      WBInteraction000237412
      WBInteraction000245703
      WBInteraction000250099
      WBInteraction000257069
      WBInteraction000260245
      WBInteraction000275695
      WBInteraction000276031
      WBInteraction000287458
      WBInteraction000317032
      WBInteraction000357156
      WBInteraction000367118
      WBInteraction000372208
      WBInteraction000380859
      WBInteraction000387501
      WBInteraction000398008
      WBInteraction000402613
      WBInteraction000414363
      WBInteraction000418429
      WBInteraction000421894
      WBInteraction000426352
      WBInteraction000426694
      WBInteraction000431233
      WBInteraction000433098
      WBInteraction000436046
      WBInteraction000439665
      WBInteraction000439738
      WBInteraction000445822
      WBInteraction000448660
      WBInteraction000458358
      WBInteraction000459768
      WBInteraction000500584
      WBInteraction000503941
      WBInteraction000508066
      WBInteraction000520373
      WBInteraction000521315
      WBInteraction000543549
      WBInteraction000547104
      WBInteraction000569796
  Map_info: Map: III Position: -1.46925 Error: 0.005315
    Well_ordered
    Positive: Positive_clone: C05D2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 2312
        2693
        4332
  Reference (69)
  Method: Gene