WormBase Tree Display for Gene: WBGene00000156
expand all nodes | collapse all nodes | view schema
WBGene00000156 | SMap | S_parent | Sequence | K04G2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | apr | ||||||
Allele (69) | |||||||
Possibly_affected_by | WBVar02153202 | ||||||
Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | ||||||
Strain | WBStrain00037280 | ||||||
WBStrain00000140 | |||||||
WBStrain00008585 | |||||||
WBStrain00024309 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (77) | |||||||
Ortholog (41) | |||||||
Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson567 | |||||||
Date_last_updated | 25 May 2011 00:00:00 | ||||||
Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (20) | ||||||
Molecular_info | Corresponding_CDS | K04G2.8a | |||||
K04G2.8b | |||||||
K04G2.8c | |||||||
Corresponding_transcript | K04G2.8a.1 | ||||||
K04G2.8b.1 | |||||||
K04G2.8c.1 | |||||||
Other_sequence | AF013950 | ||||||
CGC00612_1 | |||||||
ACC25655_1 | |||||||
EX555243.1 | |||||||
CBC06635_1 | |||||||
Associated_feature | WBsf656598 | ||||||
WBsf218114 | |||||||
Experimental_info | RNAi_result | WBRNAi00101650 | Inferred_automatically | RNAi_primary | |||
WBRNAi00101537 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062614 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091594 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099035 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101533 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101666 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091593 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099029 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101535 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099037 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077089 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00112568 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025870 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101610 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062622 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098844 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091596 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101358 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101857 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022931 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062631 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098802 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099036 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098925 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092551 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00068826 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099040 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084512 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101630 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091565 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099005 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00061053 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091598 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003922 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098815 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00068307 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00110439 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00070927 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062618 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091588 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077086 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022930 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099031 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091584 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001890 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092772 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101668 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101640 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00068229 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062621 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025869 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101468 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00070925 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101853 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101676 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00068306 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084511 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077088 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00111668 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101660 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101815 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077305 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00061056 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022928 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00092550 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101709 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00068308 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101814 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00068305 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101625 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101530 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00064700 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00068304 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098982 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101539 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077090 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101508 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101600 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091595 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091580 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077087 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099041 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098848 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077292 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00064496 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098980 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084510 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098846 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098981 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062617 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091592 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00033968 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091581 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101465 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098801 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098995 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101663 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00099004 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00070928 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098425 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00101518 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022929 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00049941 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1046 | ||||||
Expr4600 | |||||||
Expr12119 | |||||||
Expr12448 | |||||||
Expr15118 | |||||||
Expr1028112 | |||||||
Expr1030085 | |||||||
Expr1153646 | |||||||
Expr2009365 | |||||||
Expr2027601 | |||||||
Drives_construct | WBCnstr00005188 | ||||||
WBCnstr00007256 | |||||||
WBCnstr00009075 | |||||||
WBCnstr00009116 | |||||||
WBCnstr00012108 | |||||||
WBCnstr00016098 | |||||||
WBCnstr00020198 | |||||||
WBCnstr00021087 | |||||||
WBCnstr00037698 | |||||||
Construct_product | WBCnstr00000526 | ||||||
WBCnstr00007257 | |||||||
WBCnstr00007258 | |||||||
WBCnstr00009057 | |||||||
WBCnstr00009075 | |||||||
WBCnstr00012108 | |||||||
WBCnstr00016098 | |||||||
WBCnstr00020198 | |||||||
WBCnstr00021087 | |||||||
WBCnstr00037698 | |||||||
Antibody | WBAntibody00000276 | ||||||
WBAntibody00000277 | |||||||
Microarray_results (25) | |||||||
Expression_cluster (124) | |||||||
Interaction | WBInteraction000000509 | ||||||
WBInteraction000000575 | |||||||
WBInteraction000000753 | |||||||
WBInteraction000000754 | |||||||
WBInteraction000001726 | |||||||
WBInteraction000002340 | |||||||
WBInteraction000002342 | |||||||
WBInteraction000002585 | |||||||
WBInteraction000002710 | |||||||
WBInteraction000002782 | |||||||
WBInteraction000003344 | |||||||
WBInteraction000003458 | |||||||
WBInteraction000006023 | |||||||
WBInteraction000006227 | |||||||
WBInteraction000007683 | |||||||
WBInteraction000008079 | |||||||
WBInteraction000008080 | |||||||
WBInteraction000009426 | |||||||
WBInteraction000009453 | |||||||
WBInteraction000009517 | |||||||
WBInteraction000009576 | |||||||
WBInteraction000009639 | |||||||
WBInteraction000009662 | |||||||
WBInteraction000009925 | |||||||
WBInteraction000028572 | |||||||
WBInteraction000028907 | |||||||
WBInteraction000032887 | |||||||
WBInteraction000033010 | |||||||
WBInteraction000034034 | |||||||
WBInteraction000034911 | |||||||
WBInteraction000035587 | |||||||
WBInteraction000035961 | |||||||
WBInteraction000035984 | |||||||
WBInteraction000036518 | |||||||
WBInteraction000036519 | |||||||
WBInteraction000036550 | |||||||
WBInteraction000036758 | |||||||
WBInteraction000037406 | |||||||
WBInteraction000038393 | |||||||
WBInteraction000039618 | |||||||
WBInteraction000040188 | |||||||
WBInteraction000040656 | |||||||
WBInteraction000040733 | |||||||
WBInteraction000042660 | |||||||
WBInteraction000043782 | |||||||
WBInteraction000044304 | |||||||
WBInteraction000045863 | |||||||
WBInteraction000047105 | |||||||
WBInteraction000047526 | |||||||
WBInteraction000048030 | |||||||
WBInteraction000048532 | |||||||
WBInteraction000048907 | |||||||
WBInteraction000049265 | |||||||
WBInteraction000049460 | |||||||
WBInteraction000049616 | |||||||
WBInteraction000049943 | |||||||
WBInteraction000049949 | |||||||
WBInteraction000052601 | |||||||
WBInteraction000052602 | |||||||
WBInteraction000122526 | |||||||
WBInteraction000126449 | |||||||
WBInteraction000126689 | |||||||
WBInteraction000127394 | |||||||
WBInteraction000127428 | |||||||
WBInteraction000136069 | |||||||
WBInteraction000161291 | |||||||
WBInteraction000161292 | |||||||
WBInteraction000163171 | |||||||
WBInteraction000163172 | |||||||
WBInteraction000165152 | |||||||
WBInteraction000165478 | |||||||
WBInteraction000165479 | |||||||
WBInteraction000165480 | |||||||
WBInteraction000165481 | |||||||
WBInteraction000166114 | |||||||
WBInteraction000166122 | |||||||
WBInteraction000168467 | |||||||
WBInteraction000181728 | |||||||
WBInteraction000197741 | |||||||
WBInteraction000201561 | |||||||
WBInteraction000215885 | |||||||
WBInteraction000220431 | |||||||
WBInteraction000235718 | |||||||
WBInteraction000236547 | |||||||
WBInteraction000245920 | |||||||
WBInteraction000246352 | |||||||
WBInteraction000251918 | |||||||
WBInteraction000259481 | |||||||
WBInteraction000269634 | |||||||
WBInteraction000288175 | |||||||
WBInteraction000299490 | |||||||
WBInteraction000305218 | |||||||
WBInteraction000313782 | |||||||
WBInteraction000335865 | |||||||
WBInteraction000352929 | |||||||
WBInteraction000355014 | |||||||
WBInteraction000356176 | |||||||
WBInteraction000369335 | |||||||
WBInteraction000375807 | |||||||
WBInteraction000389718 | |||||||
WBInteraction000394134 | |||||||
WBInteraction000400830 | |||||||
WBInteraction000411677 | |||||||
WBInteraction000418748 | |||||||
WBInteraction000427030 | |||||||
WBInteraction000430041 | |||||||
WBInteraction000442259 | |||||||
WBInteraction000444338 | |||||||
WBInteraction000500035 | |||||||
WBInteraction000500036 | |||||||
WBInteraction000502192 | |||||||
WBInteraction000502796 | |||||||
WBInteraction000502797 | |||||||
WBInteraction000502798 | |||||||
WBInteraction000502799 | |||||||
WBInteraction000502801 | |||||||
WBInteraction000503435 | |||||||
WBInteraction000505124 | |||||||
WBInteraction000505125 | |||||||
WBInteraction000505126 | |||||||
WBInteraction000505127 | |||||||
WBInteraction000517877 | |||||||
WBInteraction000519244 | |||||||
WBInteraction000519245 | |||||||
WBInteraction000519250 | |||||||
WBInteraction000519251 | |||||||
WBInteraction000519252 | |||||||
WBInteraction000519253 | |||||||
WBInteraction000519254 | |||||||
WBInteraction000519255 | |||||||
WBInteraction000520246 | |||||||
WBInteraction000521746 | |||||||
WBInteraction000521750 | |||||||
WBInteraction000521853 | |||||||
WBInteraction000521875 | |||||||
WBInteraction000521881 | |||||||
WBInteraction000521882 | |||||||
WBInteraction000521883 | |||||||
WBInteraction000521884 | |||||||
WBInteraction000522263 | |||||||
WBInteraction000522264 | |||||||
WBInteraction000522281 | |||||||
WBInteraction000522308 | |||||||
WBInteraction000522316 | |||||||
WBInteraction000523960 | |||||||
WBInteraction000524831 | |||||||
WBInteraction000539198 | |||||||
WBInteraction000541599 | |||||||
WBInteraction000541603 | |||||||
WBInteraction000541779 | |||||||
WBInteraction000541780 | |||||||
WBInteraction000543618 | |||||||
WBInteraction000543619 | |||||||
WBInteraction000543620 | |||||||
WBInteraction000543621 | |||||||
WBInteraction000543622 | |||||||
WBInteraction000543623 | |||||||
WBInteraction000543624 | |||||||
WBInteraction000543625 | |||||||
WBInteraction000543626 | |||||||
WBInteraction000543627 | |||||||
WBInteraction000543628 | |||||||
WBInteraction000543629 | |||||||
WBInteraction000543630 | |||||||
WBInteraction000543631 | |||||||
WBInteraction000547298 | |||||||
WBInteraction000547711 | |||||||
WBInteraction000556044 | |||||||
WBInteraction000556045 | |||||||
WBInteraction000556046 | |||||||
WBInteraction000557664 | |||||||
WBInteraction000557671 | |||||||
WBInteraction000557678 | |||||||
WBInteraction000557685 | |||||||
WBInteraction000557692 | |||||||
WBInteraction000557699 | |||||||
WBInteraction000560328 | |||||||
WBInteraction000578733 | |||||||
WBInteraction000582080 | |||||||
WBProcess | WBbiopr:00000073 | ||||||
Map_info | Map | I | Position | 2.43771 | Error | 0.002342 | |
Positive | Positive_clone | K04G2 | Person_evidence | WBPerson524 | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4159 | |||||
4893 | |||||||
5616 | |||||||
Pseudo_map_position | |||||||
Reference (108) | |||||||
Picture | WBPicture0000013084 | ||||||
Remark | Data extracted from Rocheleau et al. (1997) | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |