WormBase Tree Display for Gene: WBGene00000390
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| WBGene00000390 | SMap | S_parent | Sequence | R07G3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cdc-42 | |||||||
| Sequence_name | R07G3.1 | ||||||||
| Molecular_name | R07G3.1 | ||||||||
| R07G3.1.1 | |||||||||
| CE02020 | |||||||||
| Other_name | CDC42Ce | Paper_evidence | WBPaper00001744 | ||||||
| WBPaper00002544 | |||||||||
| CELE_R07G3.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cdc-42 | ||||||||
| DB_info | Database | AceView | gene | 2H907 | |||||
| WormQTL | gene | WBGene00000390 | |||||||
| WormFlux | gene | WBGene00000390 | |||||||
| NDB | locus_tag | CELE_R07G3.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000390|UniProtKB=Q05062 | |||||||
| family | PTHR24072 | ||||||||
| NCBI | gene | 174233 | |||||||
| RefSeq | protein | NM_063197.10 | |||||||
| SwissProt | UniProtAcc | Q05062 | |||||||
| UniProt_GCRP | UniProtAcc | Q05062 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdc | ||||||||
| Reference_allele | WBVar00239200 | ||||||||
| Allele (34) | |||||||||
| Legacy_information | [C.elegansII] pk57 : Tc1 insertion, no phenotype known. Encodes homologof CDC42 (188 aa, 85% identity to human sequence, complementsyeast mutant).[Chen et al. 1993b] | ||||||||
| [C.elegansII] pk57 : Tc1 insertion, no phenotype known. Encodes homolog of CDC42 (188 aa, 85% identity to human sequence, complementsyeast mutant). [Chen et al. 1993b] | |||||||||
| Strain | WBStrain00001995 | ||||||||
| WBStrain00031653 | |||||||||
| WBStrain00036158 | |||||||||
| WBStrain00040280 | |||||||||
| WBStrain00040547 | |||||||||
| WBStrain00007532 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (63) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004357 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003239 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004287 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012532 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cdc-42 encodes a RHO GTPase; cdc-42 controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins; cdc-42 is also required for regulation of receptor-mediated endocytosis; CDC-42 is widely expressed and localizes to a number of different locations, including the cell cortex, centrosomes, recycling endosomes, and at the time of hypodermal cell fusion, to hypodermal cell boundaries. | Paper_evidence | WBPaper00004654 | |||||
| WBPaper00028526 | |||||||||
| WBPaper00030951 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables GTP binding activity and GTPase activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of nematode male tail tip morphogenesis; and regulation of cellular component organization. Located in centrosome; cytoplasm; and plasma membrane. Expressed in several structures, including AIY; P8.pa; hermaphrodite gonad; hypodermal cell; and nerve ring. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; fibrosarcoma; and rhinitis. Is an ortholog of human CDC42 (cell division cycle 42). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info (2) | |||||||||
| Models_disease_in_annotation | WBDOannot00000811 | ||||||||
| Molecular_info | Corresponding_CDS | R07G3.1 | |||||||
| Corresponding_transcript | R07G3.1.1 | ||||||||
| Other_sequence (118) | |||||||||
| Associated_feature | WBsf654891 | ||||||||
| WBsf976487 | |||||||||
| WBsf976488 | |||||||||
| WBsf976489 | |||||||||
| WBsf976490 | |||||||||
| WBsf988498 | |||||||||
| WBsf1012560 | |||||||||
| WBsf221618 | |||||||||
| WBsf221619 | |||||||||
| WBsf221620 | |||||||||
| Experimental_info | RNAi_result (70) | ||||||||
| Expr_pattern (22) | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product (23) | |||||||||
| Antibody | WBAntibody00000119 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (662) | |||||||||
| Anatomy_function | WBbtf1082 | ||||||||
| WBbtf1083 | |||||||||
| WBbtf1084 | |||||||||
| WBbtf1085 | |||||||||
| WBProcess | WBbiopr:00000015 | ||||||||
| WBbiopr:00000017 | |||||||||
| WBbiopr:00000096 | |||||||||
| Map_info | Map | II | Position | 0.5071 | |||||
| Positive | Positive_clone | R07G3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4188 | |||||||
| 4715 | |||||||||
| 5534 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (178) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
