WormBase Tree Display for Gene: WBGene00006963
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| WBGene00006963 | SMap | S_parent | Sequence | K07G5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | xpa-1 | |||||||
| Sequence_name | K07G5.2 | ||||||||
| Molecular_name | K07G5.2 | ||||||||
| K07G5.2.1 | |||||||||
| CE06130 | |||||||||
| Other_name | rad-3 | ||||||||
| CELE_K07G5.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | xpa-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 07 Mar 2008 11:17:28 | WBPerson2970 | Event | Acquires_merge | WBGene00004290 | ||||
| Name_change | Other_name | rad-3 | |||||||
| Acquires_merge | WBGene00004290 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | xpa | ||||||||
| Reference_allele | WBVar00089073 | ||||||||
| Allele (18) | |||||||||
| Legacy_information | mn157 : extremely hypersensitive to UV not to X irradiation hypersensitive to chronic MMS treatment (L1 arrest in 0.1 mM); reduced brood size (58% of wildtype). ES1 ME3. | ||||||||
| [C.elegansII] mn157 : extremely hypersensitive to UV, not to X irradiation; hypersensitive to chronic MMS treatment (L1 arrest in 0.1 mM); reduced brood size (58% of wildtype); reduced photoproduct excision; not hypersensitive to UV-psoralen. ES1 ME3. [Hartman et al. 1989; Hartman and Marshall 1992; PH] | |||||||||
| Strain | WBStrain00031577 | ||||||||
| WBStrain00034245 | |||||||||
| WBStrain00036618 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Contained_in_operon | CEOP1911 | ||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | xpa-1 encodes a DNA-binding protein orthologous to human XPA (which when mutated leads to Xeroderma Pigmentosum; OMIM:278700); xpa-1 is required for normal survival and resistance to mutagenesis in response to UV light, the extended lifespan of dauer-like mutants, and fertility; XPA-1 is required in UV-irradiated nondauer larvae to prevent WWP-1-mediated proteolysis of AMA-1; transgenic xpa-1 rescues the UV sensitivity of the null allele xpa-1(mn157); xpa-1 is a core NER (Nuclear Excision Repair) factor (other members being xpf-1, xpg-1, and ercc-1); xpa-1 is essential for the repair of UV-induced DNA lesions and has been demonstrated to be required in both the global genome repair (GGR) and transcription coupled repair (TCR) pathways; following UV irradiation, XPA-1 activity is essential for normal meiotic development, induction of germ cell apoptosis, and the survival of germ cells and somatic tissue (even at relatively low doses of UV irradiation); loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) renders animals hypersensitive to UV light at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations. | Paper_evidence | WBPaper00000565 | |||||
| WBPaper00005436 | |||||||||
| WBPaper00019141 | |||||||||
| WBPaper00027694 | |||||||||
| WBPaper00031296 | |||||||||
| WBPaper00031442 | |||||||||
| WBPaper00036260 | |||||||||
| WBPaper00035429 | |||||||||
| Person_evidence | WBPerson1684 | ||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson712 | |||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Nov 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable damaged DNA binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and response to UV-C. Located in nucleus. Human ortholog(s) of this gene implicated in xeroderma pigmentosum group A. Is an ortholog of human XPA (XPA, DNA damage recognition and repair factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110843 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12814) | ||||
| DOID:0050427 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12814) | ||||||
| Molecular_info | Corresponding_CDS | K07G5.2 | |||||||
| Corresponding_transcript | K07G5.2.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf984110 | ||||||||
| WBsf217957 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr2648 | ||||||||
| Expr8011 | |||||||||
| Expr1028701 | |||||||||
| Expr1032974 | |||||||||
| Expr1153892 | |||||||||
| Expr2018100 | |||||||||
| Expr2036238 | |||||||||
| Drives_construct | WBCnstr00013056 | ||||||||
| WBCnstr00034066 | |||||||||
| Construct_product | WBCnstr00013056 | ||||||||
| WBCnstr00034066 | |||||||||
| Regulate_expr_cluster | WBPaper00042234:xpa-1_upregulated | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (87) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000091 | |||||||||
| Map_info | Map | I | Position | 1.81181 | Error | 0.00278 | |||
| Positive | Positive_clone | K07G5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4760 | |||||||
| 364 | |||||||||
| 365 | |||||||||
| Reference | WBPaper00000565 | ||||||||
| WBPaper00000663 | |||||||||
| WBPaper00000726 | |||||||||
| WBPaper00000733 | |||||||||
| WBPaper00000994 | |||||||||
| WBPaper00001000 | |||||||||
| WBPaper00001068 | |||||||||
| WBPaper00001093 | |||||||||
| WBPaper00001154 | |||||||||
| WBPaper00001258 | |||||||||
| WBPaper00001335 | |||||||||
| WBPaper00001426 | |||||||||
| WBPaper00001460 | |||||||||
| WBPaper00001495 | |||||||||
| WBPaper00001699 | |||||||||
| WBPaper00001776 | |||||||||
| WBPaper00002199 | |||||||||
| WBPaper00002394 | |||||||||
| WBPaper00003293 | |||||||||
| WBPaper00003311 | |||||||||
| WBPaper00005436 | |||||||||
| WBPaper00013837 | |||||||||
| WBPaper00013943 | |||||||||
| WBPaper00014016 | |||||||||
| WBPaper00015284 | |||||||||
| WBPaper00015598 | |||||||||
| WBPaper00016249 | |||||||||
| WBPaper00016432 | |||||||||
| WBPaper00017690 | |||||||||
| WBPaper00019141 | |||||||||
| WBPaper00024764 | |||||||||
| WBPaper00025894 | |||||||||
| WBPaper00026064 | |||||||||
| WBPaper00027176 | |||||||||
| WBPaper00027223 | |||||||||
| WBPaper00027418 | |||||||||
| WBPaper00027694 | |||||||||
| WBPaper00029176 | |||||||||
| WBPaper00029334 | |||||||||
| WBPaper00030838 | |||||||||
| WBPaper00031296 | |||||||||
| WBPaper00031442 | |||||||||
| WBPaper00031760 | |||||||||
| WBPaper00031945 | |||||||||
| WBPaper00032410 | |||||||||
| WBPaper00035429 | |||||||||
| WBPaper00036135 | |||||||||
| WBPaper00036260 | |||||||||
| WBPaper00036831 | |||||||||
| WBPaper00036936 | |||||||||
| WBPaper00037044 | |||||||||
| WBPaper00037628 | |||||||||
| WBPaper00037879 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040448 | |||||||||
| WBPaper00040826 | |||||||||
| WBPaper00041255 | |||||||||
| WBPaper00041717 | |||||||||
| WBPaper00042234 | |||||||||
| WBPaper00044163 | |||||||||
| WBPaper00044725 | |||||||||
| WBPaper00045612 | |||||||||
| WBPaper00046901 | |||||||||
| WBPaper00047617 | |||||||||
| WBPaper00049795 | |||||||||
| WBPaper00050566 | |||||||||
| WBPaper00051192 | |||||||||
| WBPaper00053104 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00057093 | |||||||||
| WBPaper00060037 | |||||||||
| WBPaper00060267 | |||||||||
| WBPaper00060474 | |||||||||
| WBPaper00061894 | |||||||||
| WBPaper00062203 | |||||||||
| WBPaper00062826 | |||||||||
| WBPaper00064339 | |||||||||
| WBPaper00065149 | |||||||||
| Method | Gene |
