WormBase Tree Display for WBProcess: WBbiopr:00000091
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| WBbiopr:00000091 | Public_name | DNA damage response | ||||
|---|---|---|---|---|---|---|
| Summary | DNA damage can occur during normal recombination events or result from various insults, such as exposure to chemical mutagens or exposure to radiation. Metazoans have evolved mechanisms to detect, assess, and deal with any damage at specific checkpoints during the cell cycle. Studies in yeasts and mammals have identified several genes that are required for proper activation of cell cycle check-points following various types of DNA damage. However, in these metazoans, DNA damage can induce apoptosis as well. The inability to efficiently repair DNA damage or remove cells with severely damaged genomes has been linked to several human cancers. | |||||
| Other_name | DNA repair | |||||
| Global-genome nucleotide excision repair | ||||||
| GG-NER | ||||||
| Related_topic | Specialisation_of | WBbiopr:00000041 | ||||
| Involved_entity | Gene | WBGene00001997 | Paper_evidence | WBPaper00003984 | ||
| WBGene00000537 | Paper_evidence | WBPaper00005597 | ||||
| WBPaper00005024 | ||||||
| WBGene00003418 | Paper_evidence | WBPaper00005107 | ||||
| WBGene00000467 | Paper_evidence | WBPaper00004952 | ||||
| WBGene00006963 | Paper_evidence | WBPaper00029334 | ||||
| WBGene00002042 | Paper_evidence | WBPaper00005597 | ||||
| WBPaper00003984 | ||||||
| WBGene00001170 | Paper_evidence | WBPaper00005597 | ||||
| WBGene00003417 | Paper_evidence | WBPaper00003984 | ||||
| WBGene00001595 | Paper_evidence | WBPaper00024954 | ||||
| WBGene00006734 | Paper_evidence | WBPaper00050185 | ||||
| Interaction (197) | ||||||
| Associated_with | GO_term | GO:0006281 | ||||
| GO:0070911 | ||||||
| GO:0042769 | ||||||
| Pathway | DB_info | Database | WikiPathways | Pathway | WP367 | |
| Reference (11) |
