WormBase Tree Display for Gene: WBGene00018491

WBGene00018491 SMap: S_parent: Sequence: F46E10
  Identity: Version: 2
    Name: CGC_name: mdh-1 Person_evidence: WBPerson676
      Sequence_name: F46E10.10
      Molecular_name: F46E10.10
        F46E10.10.1
        CE20820
      Other_name: F46E10.g Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_F46E10.10 Accession_evidence: NDB BX284605
      Public_name: mdh-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 18 Aug 2010 11:15:35 WBPerson2970 Name_change: CGC_name: mdh-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mdh
    Allele (26)
    RNASeq_FPKM (74)
    GO_annotation (20)
    Contained_in_operon: CEOP5120
    Ortholog (42)
    Structured_description: Concise_description: mdh-1 encodes a malate dehydrogenase; by homology, MDH-1 is predicted to function to reversibly catalyze the formation of oxaloacetate from malate. Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Oct 2011 00:00:00
      Automated_description: Enables L-malate dehydrogenase activity. Involved in malate metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 88. Is an ortholog of human MDH1 (malate dehydrogenase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112222 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6970)
  Molecular_info (5)
  Experimental_info: RNAi_result: WBRNAi00015088 Inferred_automatically: RNAi_primary
      WBRNAi00106994 Inferred_automatically: RNAi_primary
      WBRNAi00047523 Inferred_automatically: RNAi_primary
      WBRNAi00033295 Inferred_automatically: RNAi_primary
      WBRNAi00088638 Inferred_automatically: RNAi_primary
      WBRNAi00103124 Inferred_automatically: RNAi_primary
      WBRNAi00088745 Inferred_automatically: RNAi_primary
      WBRNAi00103123 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr12927
      Expr1023310
      Expr1037971
      Expr1151361
      Expr2013465
      Expr2031699
    Drives_construct: WBCnstr00026475
    Construct_product: WBCnstr00026475
    Microarray_results (29)
    Expression_cluster: WBPaper00006195:azacoprostane_downregulated
      WBPaper00026720:AmyloidBeta_oxidized
      WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00030894:daf-2(e1370ts)_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00035314:acetic-acid_RF3_downregulated
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037086:biotin_regulated
      WBPaper00037109:cyclophilin-inhibitor_regulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040446:insoluble_protein
      WBPaper00040755:LRRK2(R1441C)-Tau_vs_N2_upregulated
      WBPaper00041506:EMS_enriched
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045565:BIR-1_suppressed
      WBPaper00045774:clk-1_upregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00046691:P1_enriched
      WBPaper00046741:Garlic-Extract_downregulated_protein
      WBPaper00048644:germline_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049325:CB4856_vs_N2_DEG
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051538:micro-gavity_downregulated_protein
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
      WBPaper00056900:PID-3_interacting
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058948:PA14_upregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059895:wounding_downregulated
      WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
      WBPaper00060084:DVE-1_interacting_protein_control
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:BWM_anterior
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:DB01_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00062056:lin-37(n758)_downregulated
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064257:UNG-1_interacting
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064750:1mg-nanoplastics_upregulated_protein
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4386_cluster_1_4
      cgc4489_group_8
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00025032:cluster_110
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_5
      WBPaper00036286:Pattern_C
      WBPaper00038427:lin-54_germline_changed
      WBPaper00039835:ifg-1_upregulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_15
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(PC32)
      [cgc5767]:expression_class_ME
    Interaction (52)
    WBProcess: WBbiopr:00000096
  Map_info: Map: V Position: 0.000662
    Positive: Positive_clone: F46E10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene