WormBase Tree Display for Gene: WBGene00012930

WBGene00012930 SMap: S_parent: Sequence: Y47D3A
  Identity: Version: 2
    Name: CGC_name: obr-1 Person_evidence: WBPerson1105
      Sequence_name: Y47D3A.17
      Molecular_name (18)
      Other_name: CELE_Y47D3A.17 Accession_evidence: NDB BX284603
      Public_name: obr-1
    DB_info: Database: AceView gene 3M348
        WormQTL gene WBGene00012930
        WormFlux gene WBGene00012930
        NDB locus_tag CELE_Y47D3A.17
        Panther gene CAEEL|WormBase=WBGene00012930|UniProtKB=A7DTF2
          family PTHR10972
        NCBI gene 176555
        RefSeq protein NM_001379929.1
            NM_001129258.5
            NM_001379928.1
            NM_001392212.1
            NM_067047.6
        TREEFAM TREEFAM_ID TF320922
        TrEMBL UniProtAcc A7DTF3
            Q95Q23
            Q9U2C7
            A7DTF2
            G2HK04
        UniProt_GCRP UniProtAcc A7DTF2
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 02 Jul 2004 16:55:44 WBPerson1971 Name_change: CGC_name: obr-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: obr
    Allele (310)
    RNASeq_FPKM (74)
    GO_annotation: 00005088
      00005089
      00005090
      00005091
      00005092
      00005093
      00005094
      00005095
      00008939
      00119900
    Ortholog (46)
    Paralog: WBGene00008832 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00016331 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00014215 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable sterol binding activity and sterol transporter activity. Predicted to be involved in sterol transport. Predicted to be located in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Human ortholog(s) of this gene implicated in cholangiocarcinoma and colorectal cancer. Is an ortholog of human OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4947 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8504)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8503)
  Molecular_info: Corresponding_CDS: Y47D3A.17a
      Y47D3A.17b
      Y47D3A.17c
      Y47D3A.17d
      Y47D3A.17e
    Corresponding_CDS_history: Y47D3A.17:wp20
    Corresponding_transcript (8)
    Other_sequence (51)
    Associated_feature: WBsf651499
      WBsf667431
      WBsf667432
      WBsf667433
      WBsf994322
      WBsf994323
      WBsf994324
      WBsf1015961
      WBsf1015962
      WBsf227560
  Experimental_info: RNAi_result: WBRNAi00037156 Inferred_automatically: RNAi_primary
      WBRNAi00088748 Inferred_automatically: RNAi_primary
      WBRNAi00020700 Inferred_automatically: RNAi_primary
      WBRNAi00088641 Inferred_automatically: RNAi_primary
      WBRNAi00056739 Inferred_automatically: RNAi_primary
      WBRNAi00020699 Inferred_automatically: RNAi_primary
      WBRNAi00001053 Inferred_automatically: RNAi_primary
      WBRNAi00091935 Inferred_automatically: RNAi_primary
      WBRNAi00056738 Inferred_automatically: RNAi_primary
      WBRNAi00056737 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1020877
      Expr1035727
      Expr1160203
      Expr2014591
      Expr2032824
    Microarray_results (33)
    Expression_cluster: WBPaper00006195:azacoprostane_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_embryo_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:hmc_biased
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00061651:Rectal_gland_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064716:paraquat_downregulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065841:34_0
      WBPaper00065841:64_0
      WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
      cgc4489_group_12
      cgc4489_group_24
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026980:intestine_enriched
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00037695:WC_5-day
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (16)
  Map_info: Map: III Position: 8.18707 Error: 0.038673
    Positive: Positive_clone: Y47D3A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00010145
    WBPaper00030935
    WBPaper00031877
    WBPaper00036600
    WBPaper00036763
    WBPaper00038491
    WBPaper00038615
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene