WormBase Tree Display for Gene: WBGene00010317

WBGene00010317 SMap: S_parent: Sequence: F59B8
  Identity: Version: 2
    Name: CGC_name: idh-1 Person_evidence: WBPerson261
      Sequence_name: F59B8.2
      Molecular_name: F59B8.2a
        F59B8.2a.1
        CE03436
        F59B8.2b
        CE47303
        F59B8.2c
        CE47163
        F59B8.2b.1
        F59B8.2c.1
      Other_name: CELE_F59B8.2 Accession_evidence: NDB BX284604
      Public_name: idh-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 08 Oct 2008 10:23:18 WBPerson2970 Name_change: CGC_name: idh-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: idh
    Allele (27)
    Strain: WBStrain00003527
      WBStrain00002807
      WBStrain00032810
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (38)
    Paralog: WBGene00007942 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: idh-1 encodes a predicted cytosolic isocitrate dehydrogenase; by homology, IDH-1 is predicted to catalyze the formation of alpha-ketoglutarate from isocitrate. Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Oct 2011 00:00:00
      Automated_description: Predicted to enable isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in NADP metabolic process and isocitrate metabolic process. Predicted to be located in cytosol; mitochondrion; and peroxisome. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and hematologic cancer (multiple). Is an ortholog of human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:5016 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:4928 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:3068 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:0050908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:3070 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:3907 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:417 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5382)
  Molecular_info: Corresponding_CDS: F59B8.2a
      F59B8.2b
      F59B8.2c
    Corresponding_transcript: F59B8.2a.1
      F59B8.2b.1
      F59B8.2c.1
    Other_sequence (57)
    Associated_feature: WBsf668157
      WBsf668158
      WBsf981804
      WBsf997420
      WBsf1017963
      WBsf230567
      WBsf230568
      WBsf230569
  Experimental_info: RNAi_result: WBRNAi00090634 Inferred_automatically: RNAi_primary
      WBRNAi00080812 Inferred_automatically: RNAi_primary
      WBRNAi00065271 Inferred_automatically: RNAi_primary
      WBRNAi00016084 Inferred_automatically: RNAi_primary
      WBRNAi00001636 Inferred_automatically: RNAi_primary
      WBRNAi00033293 Inferred_automatically: RNAi_primary
      WBRNAi00049155 Inferred_automatically: RNAi_primary
      WBRNAi00113980 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1063
      Chronogram1718
      Expr6263
      Expr6264
      Expr1018358
      Expr1034502
      Expr1152898
      Expr2012669
      Expr2030905
    Drives_construct: WBCnstr00003334
      WBCnstr00004581
      WBCnstr00031510
    Construct_product: WBCnstr00031510
    Microarray_results (25)
    Expression_cluster: WBPaper00026640:Development_Group_I
      WBPaper00026640:Development_Group_VI
      WBPaper00028451:Oogenic_protein
      WBPaper00029359_1142
      WBPaper00029359_1187
      WBPaper00029359_1217
      WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1524
      WBPaper00029359_1604
      WBPaper00032528:L3_enriched
      WBPaper00035073:mitochondria_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:insoluble_protein
      WBPaper00037086:biotin_regulated
      WBPaper00037109:cyclophilin-inhibitor_regulated
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:CEP-sheath-cells_adult_enriched
      WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044128:DietaryRestriction_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044616:alg-3-4_upregulated_protein
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00044786:emr-1(gk119)_downregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046887:WNT-target
      WBPaper00048579:aging_downregulated
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049083:post-dauer-development_downregulated
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056868:P.aeruginosa_downregulated_smallRNA
      WBPaper00056900:PID-3_interacting
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059529:nonu-1(srf0780)_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059895:wounding_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061221:H4K8ac_interacting
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:F_U
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:K_Kprime
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:P_cell
      WBPaper00061340:Seam_cell
      WBPaper00061340:T
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:C28H8.4-ZK418.5_10918
      WBPaper00061527:dld-1-skn-1_16701
      WBPaper00061651:CAN_enriched
      WBPaper00061651:Rectal_gland_enriched
      WBPaper00062143:PQN-59_interacting
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064257:UNG-1_interacting
      WBPaper00064315:mes-3(bn199)_downregulated_PGCs
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00064952:Day10_vs_L4_downregulated_20C
      WBPaper00064952:Day10_vs_L4_downregulated_25C
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      cgc4386_cluster_1_5
      cgc4489_group_4
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:cluster_109
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_G
      WBPaper00026980:intestine_enriched
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_G
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040963:Q200_down
      WBPaper00041207:CE_dauer_down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:cluster_14
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_ME
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (103)
  Map_info: Map: IV Position: 4.24582 Error: 0.002337
    Positive: Positive_clone: F59B8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene