WormBase Tree Display for Gene: WBGene00009824

WBGene00009824 SMap: S_parent: Sequence: F47G4
  Identity: Version: 2
    Name: CGC_name: gpdh-1 Person_evidence: WBPerson1851
      Sequence_name: F47G4.3
      Molecular_name: F47G4.3
        F47G4.3.1
        CE18701
      Other_name: CELE_F47G4.3 Accession_evidence: NDB BX284601
      Public_name: gpdh-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 12 Sep 2006 10:48:07 WBPerson2970 Name_change: CGC_name: gpdh-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gpdh
    Allele (40)
    Strain: WBStrain00032072
      WBStrain00048030
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (49)
    Paralog: WBGene00010778 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: gpdh-1 encodes one of two C. elegans glycerol 3-phosphate dehydrogenases; gpdh-1 mRNA expression is upregulated in response to hypertonicity, suggesting that GPDH-1 does play a role in osmotic stress adaptation in C. elegans via glycerol biosynthesis; regulation of gpdh-1 expression is controlled, in part, by a pathway that includes the OSM-8 mucin and the PTR-23 Patched-like receptor. Paper_evidence: WBPaper00006432
            WBPaper00038064
          Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Apr 2011 00:00:00
      Automated_description: Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to be located in cytosol. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Is an ortholog of human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:28956)
  Molecular_info: Corresponding_CDS: F47G4.3
    Corresponding_transcript: F47G4.3.1
    Other_sequence: GO238924.1
    Associated_feature (14)
  Experimental_info: RNAi_result: WBRNAi00032450 Inferred_automatically: RNAi_primary
      WBRNAi00003699 Inferred_automatically: RNAi_primary
      WBRNAi00113945 Inferred_automatically: RNAi_primary
      WBRNAi00047681 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3986
      Expr1010915
      Expr1034292
      Expr1151522
      Expr2012209
      Expr2030445
    Drives_construct: WBCnstr00000751
      WBCnstr00008693
      WBCnstr00031890
      WBCnstr00038242
    Construct_product: WBCnstr00031890
    Microarray_results (19)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-35_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040560:hpl-2_L3_upregulated
      WBPaper00042034:NO_upregulated_N2
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044316:CH3HgCl_2.0uM_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044557:DietaryRestriction_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:lem-2(tm1582)_upregulated
      WBPaper00044857:BAR-1_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_totalRNA_tiling
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00047132:glp-1(ts)-25C_upregulated_skn-1-dependent
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048952:glucose_induced
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049134:hpk-1(pk1393)_downregulated
      WBPaper00049159:Microwave_upregulated_L4
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051371:Orsay-virus-infection_upregulated_rde-1(ne219)
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051404:alg-5(ram2)_downregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_upregulated_OP50
      WBPaper00054410:set-9(rw5)_upregulated
      WBPaper00054626:NO_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_downregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056169:rrf-3(pk1426)_downregulated_adult
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056218:daf-16(mu86)_downregulated_Day5
      WBPaper00056218:daf-16(mu86)_downregulated_Day7
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056284:ints-11(RNAi)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:flcn-1(ok975)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056826:SGP_biased
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057196:raga-1(ok386)_upregulated)
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00057265:metaformin_upregulated_OP50-MR
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058711:paraquat_upregulated
      WBPaper00058711:skn-1(lax188)_downregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_downregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059537:ngn-1(ok2200)_downregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_upregulated_N2
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(overexpression)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060886:met-2(n4256)_upregulated
      WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:P_cell
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00061952:daf-18(yh1)_upregulated
      WBPaper00062056:met-2(n4256)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062672:dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064602:egl-9(sa307)_downregulated
      WBPaper00064661:lpd-3(ok2138)_downregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065272:dhgd-1(tm6671)_downregulated
      WBPaper00065315:mating_upregulated_Day6-7
      WBPaper00065392:Lb.gasseri_upregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065581:hpk-1(pk1393)_downregulated
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065746:tmc-1(rg1003)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065835:mtH2S-AP39-L1-treatment_upregulated_Day11
      WBPaper00065841:6_0
      WBPaper00065841:52_0
      WBPaper00065841:57_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_upregulated_mRNA
      cgc4386_cluster_2_4
      cgc4489_group_8
      WBPaper00006465:I_ethanol_rapid_induction
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00028789:PA14_vs_gacA_downregulated_4hr
      WBPaper00028789:PA14_vs_gacA_downregulated_8hr
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00032948:FedUp
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036286:Pattern_I
      WBPaper00037113:CPF_DZN_16C_down-regulated
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00039792:TempShiftDecrease
      WBPaper00040116:pRJ-FR.5_down_regulated
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040876:mir-35_upregulated
      WBPaper00040963:Q100_down
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041267:SpaceFlight_Downregulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045401:N.parisii_34h_upregulated_N2
      WBPaper00045437:Toxic-Se_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00050650:mBmkTX_downregulated
      WBPaper00050767:Octopamine_induced
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053688:E.faecalis_downregulated
      [cgc6390]:male_sex-enriched
    Interaction (173)
  Map_info: Map: I Position: 23.0163 Error: 0.010903
    Positive: Positive_clone: F47G4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene