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WormBase Tree Display for Gene: WBGene00009813

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Name Class

WBGene00009813SMapS_parentSequenceF47B10
IdentityVersion2
Name (5)
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:50WBPerson1971EventImportedInitial conversion from CDS class of WS125
212 Apr 2011 11:48:32WBPerson2970Name_changeCGC_namehaly-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhaly
Allele (44)
StrainWBStrain00040582
WBStrain00040583
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (30)
Structured_descriptionConcise_descriptionhaly-1 encodes a histidine ammonia lyase orthologous to the human gene HISTIDASE (HAL; OMIM:235800); HALY-1 is required in C. elegans for conversion of histidine to urocanic acid via reductive deamination; loss-of-function mutations in haly-1 result in protection against zinc and nickel toxicity owing to increased levels of metal-chelating histidine; genetic studies suggest that haly-1 functions in parallel to members of the cation diffusion facilitator family of zinc transporters encodes by cdf-1, cdf-2, and sur-7 to modulate zinc sensitivity; haly-1 mRNA levels do not vary under different dietary zinc conditions.Paper_evidenceWBPaper00031911
WBPaper00038278
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated04 Apr 2011 00:00:00
Automated_descriptionPredicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0060168Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4806)
Molecular_infoCorresponding_CDSF47B10.2
Corresponding_transcriptF47B10.2.1
Other_sequence (79)
Associated_featureWBsf654368
WBsf237907
WBsf237908
Experimental_infoRNAi_resultWBRNAi00015146Inferred_automaticallyRNAi_primary
WBRNAi00047595Inferred_automaticallyRNAi_primary
WBRNAi00032403Inferred_automaticallyRNAi_primary
Expr_patternChronogram1244
Expr6096
Expr1025610
Expr1034288
Expr1151431
Expr2012363
Expr2030599
Drives_constructWBCnstr00003174
WBCnstr00020173
WBCnstr00031899
Construct_productWBCnstr00020173
WBCnstr00031899
Microarray_results (22)
Expression_clusterWBPaper00029359_1166
WBPaper00029359_1197
WBPaper00029359_1291
WBPaper00029359_1546
WBPaper00029359_1549
WBPaper00029359_1557
WBPaper00029359_1599
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032031:DConiospora_downregulated_OligoArray_24h
WBPaper00032425:down_in_alg-1
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035269:cde-1_regulated
WBPaper00037950:germline-precursors_embryo_enriched
WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
WBPaper00037950:hypodermis_embryo_enriched
WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040221:DAF-12_target_ALF4
WBPaper00040990:PA14_upregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044743:wdr-23_neuron_upregulated
WBPaper00045314:S.aureus-induced_N2
WBPaper00045420:fertilization_upregulated_transcript
WBPaper00045521:Spermatogenic
WBPaper00045571:germline-ablation_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046012:tdp-1(ok803)_upregulated
WBPaper00046121:ecdoderm_unique
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_downregulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
WBPaper00049954:BPA_downregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050344:PLM-neuron_enriched
WBPaper00050448:KGB-1-induced
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:hypodermis_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051388:Glucose-diet_downregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053615:SMO-1_target
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:clk-1(qm30)_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:15C_downregulated_OP50
WBPaper00053814:25C_upregulated_PY79
WBPaper00054872:egl-9(sa307)_downregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056218:daf-16(mu86)_upregulated_Day3
WBPaper00056218:daf-16(mu86)_upregulated_Day5
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058648:Y37A1B.5(RNAi)_downregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058711:skn-1(lax188)_upregulated
WBPaper00059117:B.subtilis_downregulated
WBPaper00059253:stearic-acid_downregulated
WBPaper00059605:mut-16(pk710)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060458:rnf-5(tm794)_regulated
WBPaper00060526:plp-1(ok2155)_downregulated
WBPaper00060683:hlh-11(overexpression)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-extract_1h_regulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Tail_hypodermis
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:C18B2.5-haf-4_181
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00062143:PQN-59_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00063976:micu-1(bon20)_upregulated
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-3(bn199)_upregulated_PGCs
WBPaper00064494:postdauer_upregulated_AWA
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064992:Capsaicin_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065258:anchor-cell_enriched
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
WBPaper00065841:2_0
WBPaper00065841:30_1
WBPaper00065841:30_2
WBPaper00065841:30_5
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
WBPaper00066085:hda-3(ok1991)_upregulated
cgc4386_cluster_1_6
cgc4489_group_3
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030985:Enterococcus_faecalis_downregulated
WBPaper00032165:A_to_C_transit_increased
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00034757:up_by_oxidative_stress
WBPaper00035227:heat_shock_regulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-7_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035873:osm-11_regulated
WBPaper00035873:osmotically_regulated
WBPaper00035892:KIM5_vs_OP50_Up
WBPaper00035892:Y.pestis_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_G
WBPaper00037695:CC_3-day
WBPaper00038304:octr-1_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040963:Q50_down
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041906:I-3690_vs_OP50_10d
WBPaper00041906:I-4317_vs_OP50_10d
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00045865:biofilm_upregulated_A
WBPaper00048624:hlh-25(ok1710)_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00050767:Octopamine_induced
WBPaper00056330:mrps-5(RNAi)_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
Interaction (19)
Map_infoMapXPosition2.67922
PositivePositive_cloneF47B10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (10)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene