WormBase Tree Display for Gene: WBGene00008832

WBGene00008832 SMap: S_parent: Sequence: F14H8
  Identity: Version: 2
    Name: CGC_name: obr-2 Person_evidence: WBPerson1105
      Sequence_name: F14H8.1
      Molecular_name: F14H8.1a
        F14H8.1a.1
        CE35859
        F14H8.1b
        CE42504
        F14H8.1c
        CE46315
        F14H8.1b.1
        F14H8.1c.1
      Other_name: CELE_F14H8.1 Accession_evidence: NDB BX284605
      Public_name: obr-2
    DB_info: Database: AceView gene 5P492
        WormQTL gene WBGene00008832
        WormFlux gene WBGene00008832
        NDB locus_tag CELE_F14H8.1
        Panther gene CAEEL|WormBase=WBGene00008832|UniProtKB=Q93485
          family PTHR10972
        NCBI gene 180003
        RefSeq protein NM_001269713.3
            NM_074294.5
            NM_001129445.5
        TrEMBL UniProtAcc B2D6P3
            G1K0Y0
            Q93485
        UniProt_GCRP UniProtAcc Q93485
        OMIM gene 606731
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 02 Jul 2004 16:55:44 WBPerson1971 Name_change: CGC_name: obr-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: obr
    Allele (52)
    RNASeq_FPKM (74)
    GO_annotation: 00005827
      00005828
      00005829
      00005830
      00005831
      00005832
      00005833
      00005834
      00116678
    Contained_in_operon: CEOP5436
    Ortholog (40)
    Paralog: WBGene00016331 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00014215 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012930 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable sterol binding activity and sterol transporter activity. Predicted to be involved in sterol transport. Predicted to be located in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Is an ortholog of human OSBPL2 (oxysterol binding protein like 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110588 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:15761)
  Molecular_info (5)
  Experimental_info: RNAi_result: WBRNAi00091954 Inferred_automatically: RNAi_primary
      WBRNAi00023422 Inferred_automatically: RNAi_primary
      WBRNAi00002181 Inferred_automatically: RNAi_primary
      WBRNAi00023711 Inferred_automatically: RNAi_primary
      WBRNAi00023199 Inferred_automatically: RNAi_primary
      WBRNAi00023999 Inferred_automatically: RNAi_primary
      WBRNAi00030972 Inferred_automatically: RNAi_primary
      WBRNAi00044661 Inferred_automatically: RNAi_primary
      WBRNAi00013328 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1026580
      Expr1033851
      Expr1148634
      Expr2014592
      Expr2032825
    Drives_construct: WBCnstr00032649
    Construct_product: WBCnstr00032649
    Microarray_results (21)
    Expression_cluster: WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00031040:Cluster_5
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045420:fertilization_downregulated_protein
      WBPaper00045521:Spermatogenic
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045774:clk-1_upregulated_CoQ10_dependent
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00048988:daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049732:blmp-1(tm548)_vs_N2_downregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:ADEsh
      WBPaper00061340:CEPsh
      WBPaper00061340:CEPso
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:ILso
      WBPaper00061527:snt-4_17845-T27C4.1
      WBPaper00061651:URB_enriched
      WBPaper00061651:XXX_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065841:40_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_19
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_E
      WBPaper00037695:WC_5-day
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040876:mir-35_downregulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053827:pyoverdine_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(53_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_A
      [cgc6390]:mixed_spermatogenesis-somatic
    Interaction: WBInteraction000036699
      WBInteraction000043519
      WBInteraction000360775
      WBInteraction000376388
      WBInteraction000399470
      WBInteraction000406894
      WBInteraction000425665
      WBInteraction000447238
  Map_info: Map: V Position: 7.16225 Error: 0.005018
    Positive: Positive_clone: F14H8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00010008
    WBPaper00010145
    WBPaper00025402
    WBPaper00030935
    WBPaper00038491
    WBPaper00055090
    WBPaper00062625
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene