WormBase Tree Display for Gene: WBGene00007718

WBGene00007718 SMap: S_parent: Sequence: C25D7
  Identity: Version: 2
    Name: CGC_name: otub-1 Person_evidence: WBPerson1847
      Sequence_name: C25D7.8
      Molecular_name: C25D7.8
        C25D7.8.1
        CE08394
      Other_name: CELE_C25D7.8 Accession_evidence: NDB BX284605
      Public_name: otub-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 30 Jul 2008 10:28:41 WBPerson2970 Name_change: CGC_name: otub-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: otub
    Allele (28)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Contained_in_operon: CEOP5440
    Ortholog (39)
    Paralog: WBGene00017754 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Automated_description: Enables cysteine-type deubiquitinase activity. Predicted to be involved in proteolysis. Located in plasma membrane. Expressed in distal tip cell; neuronal sheath cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and lupus nephritis. Is an ortholog of human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080162 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23077)
      DOID:2986 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23077)
  Molecular_info: Corresponding_CDS: C25D7.8
    Corresponding_transcript: C25D7.8.1
    Other_sequence (28)
    Associated_feature (4)
  Experimental_info: RNAi_result: WBRNAi00041176 Inferred_automatically: RNAi_primary
      WBRNAi00029190 Inferred_automatically: RNAi_primary
      WBRNAi00041177 Inferred_automatically: RNAi_primary
      WBRNAi00062133 Inferred_automatically: RNAi_primary
      WBRNAi00011156 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4842
      Expr9442
      Expr1018860
      Expr1033342
      Expr1145208
      Expr2014665
      Expr2032898
    Drives_construct: WBCnstr00012270
      WBCnstr00033532
    Construct_product: WBCnstr00014007
      WBCnstr00033532
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060871:M.humicola-infection_12h_regulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:ALN
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:URA_parent
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:ima-1_20458-bath-41
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064005:starvation_upregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_4_3
      cgc4489_group_2
      WBPaper00025032:cluster_1
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031184:acrylamide_downregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00036286:Pattern_B
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:intrinsic
    Interaction (26)
  Map_info: Map: V Position: 7.28708 Error: 0.013281
    Positive: Positive_clone: C25D7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00030839
    WBPaper00033022
    WBPaper00038444
    WBPaper00038491
    WBPaper00041103
    WBPaper00049828
    WBPaper00055090
    WBPaper00061547
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene