WormBase Tree Display for Gene: WBGene00006948

WBGene00006948 SMap: S_parent: Sequence: F52E4
  Identity: Version: 1
    Name: CGC_name: wrt-2 Person_evidence: WBPerson83
      Sequence_name: F52E4.6
      Molecular_name: F52E4.6
        F52E4.6.1
        CE07273
      Other_name: CELE_F52E4.6 Accession_evidence: NDB BX284606
      Public_name: wrt-2
    DB_info: Database (10)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: wrt
    Allele (28)
    Strain: WBStrain00007244
      WBStrain00007245
      WBStrain00007246
      WBStrain00007914
      WBStrain00032807
    RNASeq_FPKM (74)
    Ortholog (23)
    Paralog (24)
    Structured_description: Concise_description: wrt-2 encodes a hedgehog-like protein, with an N-terminal signalsequence, a Wart domain, and a C-terminal region of low-complexitysequence; WRT-2 is expressed in seam cells and hypodermal syncytia; theWart domain is predicted to form a cysteine-crosslinked protein involvedin intercellular signalling, and it has subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; WRT-2 is weakly requiredfor normal molting; WRT-2 is also required for normal growth to fullsize and locomotion; all of these requirements may reflect commondefects in cholesterol-dependent hedgehog-like signalling or in vesicletrafficking; in two-hybrid assays, WRT-2 binds EYA-1, which may parallelthe derepression of Drosophila eyes absent by HEDGEHOG. Paper_evidence: WBPaper00003717
            WBPaper00006332
            WBPaper00026841
            WBPaper00027263
            WBPaper00027697
          Curator_confirmed: WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Expressed in hypodermal cell and hypodermis. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F52E4.6
    Corresponding_transcript: F52E4.6.1
    Other_sequence (41)
    Associated_feature: WBsf653804
      WBsf653805
      WBsf1022564
      WBsf1022565
      WBsf1022566
      WBsf237135
      WBsf237136
  Experimental_info: RNAi_result: WBRNAi00077008 Inferred_automatically: RNAi_primary
      WBRNAi00047999 Inferred_automatically: RNAi_primary
      WBRNAi00076981 Inferred_automatically: RNAi_primary
      WBRNAi00015424 Inferred_automatically: RNAi_primary
      WBRNAi00032625 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr642
      Expr13913
      Expr1027232
      Expr1032962
      Expr1151814
      Expr2018077
      Expr2036215
    Drives_construct (22)
    Construct_product: WBCnstr00034080
    Microarray_results (18)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00032031:DConiospora_downregulated_cDNA_24h
      WBPaper00032528:L3_enriched
      WBPaper00032976:non_compensated_genes
      WBPaper00035197:fer-1_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00043945:MeHg_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045017:blmp-1(tm548)_downregulated
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046121:mesoderm_unique
      WBPaper00046497:B.thuringiensis_downregulated_protein
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048423:LP133_LF21_downregulated
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050843:sesamin_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051021:4-bromodiphenyl-ether_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_L1
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057149:prgn-1(tm985)_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057347:nhr-14(tm1473)_downreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058678:DAF-12_downregulated_PVD
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059231:alh-6(lax105)_L4_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060273:vrk-1(RNAi)_downregulated
      WBPaper00060445:ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Hypodermis
      WBPaper00061340:Seam_cell
      WBPaper00061340:Tail_hypodermis
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:mlt-9_22518-F33D4.6_14044
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00062056:lin-37(n758)_downregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062347:blmp-1(tm548)_downregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)_upregulated
      WBPaper00062684:pathogen_upregulated_N2
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064532:pals-25(icb98)_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064841:tent-5(tm3504)_downregulated_transcript
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064952:Day1_vs_L4_downregulated_20C
      WBPaper00064952:Day5_vs_Day1_downregulated_25C
      WBPaper00064952:Day5_vs_L4_downregulated_20C
      WBPaper00064952:Day5_vs_L4_downregulated_25C
      WBPaper00064952:Day10_vs_L4_downregulated_20C
      WBPaper00064952:Day10_vs_L4_downregulated_25C
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065225:nhr-42(tm1375)_upregulated_uninfected
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:82_0
      WBPaper00065841:114_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066004:tdp-1(csb38)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00066232:ash-2(RNAi)_upregulated_WT
      cgc4386_cluster_5_6
      cgc4489_group_23
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026952:class_E
      WBPaper00026980:intestine_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00032948:FedUp
      WBPaper00032948:MoltOssilate
      WBPaper00034739:N2lessDR1350
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00036383:ash-2_L3_regulated
      WBPaper00038172:aak-2overexpression_down_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00041207:CE_dauer_down
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042258:DA1877_downregulated_YoungAdult
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_B
      [cgc6390]:male_sex-enriched
    Interaction (101)
    WBProcess: WBbiopr:00000123
  Map_info: Map: X Position: -12.232 Error: 0.019344
    Positive: Positive_clone: F52E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene