| WBGene00006592 | SMap | S_parent | Sequence | R151 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | dpy-31 | Paper_evidence | WBPaper00024637 |
| | | Sequence_name | R151.5 |
| | | Molecular_name | R151.5a |
| | | | R151.5a.1 |
| | | | CE27200 |
| | | | R151.5a.2 |
| | | | R151.5b |
| | | Other_name | nas-35 | CGC_data_submission |
| | | | toh-2 | Paper_evidence | WBPaper00024637 |
| | | | | Person_evidence | WBPerson465 |
| | | | CELE_R151.5 | Accession_evidence | NDB | BX284603 |
| | | Public_name | dpy-31 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 13 Jun 2005 09:49:17 | WBPerson2970 | Name_change | CGC_name | dpy-31 |
| | | | | | | | Other_name | toh-2 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dpy |
| | Allele (80) |
| | Legacy_information | [C.elegansII] NMK. Encodes protein with BMP-1 similarity. [LT] |
| | Strain | WBStrain00002101 |
| | | WBStrain00002309 |
| | | WBStrain00004667 |
| | | WBStrain00004681 |
| | | WBStrain00004687 |
| | | WBStrain00004688 |
| | | WBStrain00004691 |
| | | WBStrain00004697 |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Ortholog (31) |
| | Paralog (48) |
| | Structured_description | Concise_description | dpy-31 encodes an astacin zinc-metalloprotease of the BMP-1 (bone morphogenetic protein-1)/TOLLOID family; dpy-31 activity is required for proper cuticle formation and thus for normal body morphology; in addition, dpy-31 is essential for embryonic and larval development at 25 degrees C; genetic and immunofluorescence studies suggest that DPY-31 functions as an endopeptidase that is required for processing, and ultimately proper extracellular assembly, of the SQT-3 cuticle collagen; dpy-31 is expressed in most hypodermal cells, with the exception of larval stage seam cells, throughout the life cycle with particularly strong expression seen during embryonic and larval stages; dpy-31 is also expressed in some head neurons, the amphid socket cells, rectal epithelial cells, and vulval epithelial cells in L4 larvae and adults. | Paper_evidence | WBPaper00024637 |
| | | | | | WBPaper00027067 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 08 Aug 2006 00:00:00 |
| | | Automated_description | Predicted to enable metalloendopeptidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in extracellular region. Expressed in several structures, including amphid sheath cell; excretory duct; hypodermis; socket cell; and vulva. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | R151.5a |
| | Corresponding_CDS_history | R151.5b:wp248 |
| | Corresponding_transcript | R151.5b |
| | | R151.5a.1 |
| | | R151.5a.2 |
| | Other_sequence (44) |
| | Associated_feature (4) |
| Experimental_info | RNAi_result | WBRNAi00089138 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061425 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061415 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00005194 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00017871 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00051977 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061424 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00002877 |
| | | WBCnstr00002878 |
| | | WBCnstr00004447 |
| | | WBCnstr00011166 |
| | | WBCnstr00013625 |
| | | WBCnstr00015220 |
| | | WBCnstr00020247 |
| | | WBCnstr00020355 |
| | | WBCnstr00034283 |
| | Construct_product | WBCnstr00011166 |
| | | WBCnstr00013625 |
| | | WBCnstr00016573 |
| | | WBCnstr00034283 |
| | Antibody | WBAntibody00002061 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1678 |
| | | WBPaper00029359_1681 |
| | | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00032425:up_in_rde-4 |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045314:S.aureus-induced_hlh-30(tm1978) |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045861:ash-2(tm1095)_upregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051311:VGLN-1-interacting |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053771:up_at_3h-NaCl |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057162:meg-3_meg-4_upregulated_sRNA |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:g1P |
| | | WBPaper00061340:hyp1V_and_ant_arc_V |
| | | WBPaper00061340:hyp1_hyp2 |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Neuroblast_BAG_SMDVx |
| | | WBPaper00061340:pm1_pm2 |
| | | WBPaper00061340:pm3_pm4_pm5 |
| | | WBPaper00061340:pm7 |
| | | WBPaper00061340:XXX |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:ttr-18-C54D10.3 |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated_germline |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062590:Aging_downregulated_hypodermis |
| | | WBPaper00062715:blmp-1(s71)_upregulated |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064494:postdauer_downregulated_AWA |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065199:Transgeneration-starvation_regulated_fed |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11 |
| | | WBPaper00065841:2_0 |
| | | WBPaper00065841:30_2 |
| | | WBPaper00065841:33_0 |
| | | WBPaper00065841:33_1 |
| | | WBPaper00065841:82_1 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4489_group_24 |
| | | WBPaper00025032:cluster_5 |
| | | WBPaper00025032:cluster_118 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027758:Group_III |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_6 |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-7_regulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00035873:osmotically_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00037695:LD_DD_6-day |
| | | WBPaper00038172:aak-2overexpression_down_regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042178:hlh-29(tm284)_upregulated |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00045263:ProLongevity-mtROS_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | Interaction | WBInteraction000004828 |
| | | WBInteraction000005319 |
| | | WBInteraction000005375 |
| | | WBInteraction000052808 |
| | | WBInteraction000052809 |
| | | WBInteraction000579000 |
| Map_info | Map | III | Position | -0.771 |
| | Positive | Positive_clone | R151 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5431 |
| | | | 4146 |
| | Pseudo_map_position |
| Reference (25) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| | [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-0.771285) |
| Method | Gene |
