WormBase Tree Display for Gene: WBGene00004052

WBGene00004052 SMap: S_parent: Sequence: H23L24
  Identity: Version: 2
    Name: CGC_name: parg-2 Person_evidence: WBPerson236
      Sequence_name: H23L24.5
      Molecular_name: H23L24.5
        H23L24.5.1
        CE32685
      Other_name: pme-4
        CELE_H23L24.5 Accession_evidence: NDB BX284604
      Public_name: parg-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 18 Nov 2014 11:51:19 WBPerson2970 Name_change: CGC_name: parg-2
                Other_name: pme-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: parg
    Allele (43)
    Strain (3)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (41)
    Paralog: WBGene00004051 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: parg-2 (formerly known as pme-4) encodes a poly(ADP-ribose) glycohydrolase (PARG) orthologous to human PARG (OMIM:603501) and paralogous to PARG-1; PARG-2 exhibits poly(ADP-ribose) glycohydrolase activity in vitro, and is required in vivo for normal resistance to ionizing radiation; PARG-2 is primarily expressed in the cytoplasm of nerve cells in the head and tail, and also in embryos; neuronal expression of PARG-2 may reflect a requirement for PARG in preventing neurodegeneration like that seen in Drosophila. Paper_evidence: WBPaper00005600
            WBPaper00028953
            WBPaper00029104
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in cytoplasm. Expressed in head neurons and tail neurons. Is an ortholog of human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: H23L24.5
    Corresponding_CDS_history: H23L24.5:wp90
    Corresponding_transcript: H23L24.5.1
    Associated_feature: WBsf668121
      WBsf230456
  Experimental_info: RNAi_result: WBRNAi00013332 Inferred_automatically: RNAi_primary
      WBRNAi00033743 Inferred_automatically: RNAi_primary
      WBRNAi00016298 Inferred_automatically: RNAi_primary
      WBRNAi00065517 Inferred_automatically: RNAi_primary
      WBRNAi00049464 Inferred_automatically: RNAi_primary
      WBRNAi00065516 Inferred_automatically: RNAi_primary
      WBRNAi00102083 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4510
      Expr1016211
      Expr1153191
      Expr2014733
      Expr2032967
    Drives_construct: WBCnstr00004939
      WBCnstr00037944
    Construct_product: WBCnstr00037944
    Microarray_results (17)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040285:H2S_12hr_downregulated
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00041071:spe-44_upregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042034:NO_upregulated_hsf-1(sy441)
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-2(RNAi)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045774:clk-1_downregulated
      WBPaper00045774:clk-1_downregulated_CoQ10_independent
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049018:ham-3(RNAi)_upregulated
      WBPaper00049134:hpk-1(pk1393)_upregulated
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049498:npr-1(ur89)_regulated_5
      WBPaper00049635:dop-1(vs100)_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_adult_25C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00053092:procyanidins_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053402:his-3(RNAi)_upregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053657:JU2519_M.humicola-infection_24hr
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00054810:deoxynivalenol_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
      WBPaper00057196:raga-1(ok386)_downregulated)
      WBPaper00057265:metaformin_downregulated_OP50
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059191:hsp-16.2p-LIN-29_upregulated
      WBPaper00059194:klf-1(RNAi)_regulated
      WBPaper00059231:alh-6(lax105)_L4_downregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-3(mgDf90)_upregulated
      WBPaper00059490:dcr-1(m9375)_downregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060273:isp-1(qm150)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060871:M.humicola-infection_24h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061340:ALA
      WBPaper00061340:AVA
      WBPaper00061340:AVK
      WBPaper00061340:DA
      WBPaper00061340:DVA
      WBPaper00061340:RIA
      WBPaper00061340:RID
      WBPaper00061340:RME
      WBPaper00061340:RMED
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061340:SMD
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061390:daf-22(ok693)_ascarosides_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:C10C5.2-Y58A7A.3
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061613:human-alpha-Synuclein(A53T)_downregulated
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061692:acivicin_upregulated
      WBPaper00061823:mex-3(spr9)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062305:P.brevicompactum_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062344:grh-1(overexpression)_upregulated
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00062672:dcp-66(RNAi)_downregulated
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064502:spe-44(fx110)_upregulated
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064762:freezing-thaw_regulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065560:E.coli-HB101_upregulated_P0
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065746:tmc-1(rg1003)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065841:13_0
      WBPaper00065841:25_0
      WBPaper00065841:31_0
      WBPaper00065841:57_0
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00027111:rde-3(ne298)_upregulated
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00028789:PA14_vs_gacA_upregulated_8hr
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035429:UVC_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035891:PA_induced_zip-2_dependent
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036383:ash-2_L3_regulated
      WBPaper00037113:Diazinon_16C_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044013:nasp-1_downregulated
      WBPaper00044535:male_upregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00050650:mBmkTX_upregulated
      WBPaper00050767:Octopamine_induced
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
    Interaction: WBInteraction000253282
      WBInteraction000580252
  Map_info: Map: IV Position: 3.95647 Error: 0.001836
    Positive: Positive_clone: H23L24 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4592
        4940
    Pseudo_map_position
  Reference (11)
  Remark: Sequence connection via email from [Desnoyers S], [krb 020729]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene