parg-2 (formerly known as pme-4) encodes a poly(ADP-ribose) glycohydrolase (PARG) orthologous to human PARG (OMIM:603501) and paralogous to PARG-1; PARG-2 exhibits poly(ADP-ribose) glycohydrolase activity in vitro, and is required in vivo for normal resistance to ionizing radiation; PARG-2 is primarily expressed in the cytoplasm of nerve cells in the head and tail, and also in embryos; neuronal expression of PARG-2 may reflect a requirement for PARG in preventing neurodegeneration like that seen in Drosophila.
Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in cytoplasm. Expressed in head neurons and tail neurons. Is an ortholog of human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase).
Sequence connection via email from [Desnoyers S], [krb 020729]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.