| WBGene00003920 | SMap | S_parent | Sequence | M117 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | par-5 | Person_evidence | WBPerson314 |
| | | Sequence_name | M117.2 |
| | | Molecular_name | M117.2a |
| | | | M117.2a.1 |
| | | | CE06200 |
| | | | M117.2b |
| | | | CE48396 |
| | | | M117.2a.2 |
| | | | M117.2a.3 |
| | | | M117.2a.4 |
| | | | M117.2b.1 |
| | | Other_name | ftt-1 |
| | | | CELE_M117.2 | Accession_evidence | NDB | BX284604 |
| | | Public_name | par-5 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | par |
| | Allele (23) |
| | Legacy_information | [C.elegansII] it55 : maternal effect lethal; 2nd cleavage spindles transverse, asters spherical (resembles Par-2); most embryos lack gut granules. OA1. [Morton et al. 1992; KK] |
| | | [C.elegansII] NMK. Encodes predicted protein 78% identicalto Drosophila and bovine 14-3-3 proteins. [Wang and Shakes 1994; DS] |
| | Strain | WBStrain00023556 |
| | RNASeq_FPKM (74) |
| | GO_annotation (31) |
| | Ortholog (48) |
| | Paralog | WBGene00001502 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00010919 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | PAR-5 encodes one of two C. elegans 14-3-3 proteins; par-5 is essential for early embryonic development, particularly for early embryonic asymmetry; PAR-5 also functions in a Wnt/MAPK signaling pathway to regulate the nuclear level of the POP-1/TCF transcription factor; PAR-5 has been shown to physically interact with a number of proteins, including those involved in G protein signaling pathways and regulation of adult lifespan. | Paper_evidence | WBPaper00005079 |
| | | | | | WBPaper00006460 |
| | | | | | WBPaper00027195 |
| | | | | | WBPaper00027682 |
| | | | | | WBPaper00027763 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 22 Mar 2011 00:00:00 |
| | | Automated_description | Involved in several processes, including cellular localization; determination of adult lifespan; and first cell cycle pseudocleavage. Located in cell cortex and nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ovarian cancer; and urinary bladder cancer. Is an ortholog of human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:8719 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) |
| | | DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) |
| | | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) |
| | | DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12855) |
| | | DOID:2101 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) |
| | | DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) |
| Molecular_info | Corresponding_CDS | M117.2a |
| | | M117.2b |
| | Corresponding_transcript | M117.2a.1 |
| | | M117.2a.2 |
| | | M117.2a.3 |
| | | M117.2a.4 |
| | | M117.2b.1 |
| | Other_sequence (92) |
| | Associated_feature (12) |
| Experimental_info | RNAi_result (81) |
| | Expr_pattern (13) |
| | Drives_construct (11) |
| | Construct_product (13) |
| | Antibody | WBAntibody00000448 |
| | Microarray_results (27) |
| | Expression_cluster | WBPaper00024704:Soluble_protein |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00040446:insoluble_protein |
| | | WBPaper00040529:TWE_regulated |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044128:daf-2(e1370)_downregulated |
| | | WBPaper00044128:DietaryRestriction_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050636:aging_regulated_insoluble_protein |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051538:micro-gavity_downregulated_protein |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00054996:membranous_oraganelle_CE |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056900:ERH-2_interacting |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00056900:TOFU-6_interacting |
| | | WBPaper00056900:TOST-1_interacting |
| | | WBPaper00056997:NMAD-1_interacting |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061221:H4K8ac_interacting |
| | | WBPaper00061340:AIN |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ASG |
| | | WBPaper00061340:ASI |
| | | WBPaper00061340:ASJ |
| | | WBPaper00061340:AWA |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RIM |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:nhr-46_2300-unc-108_2961 |
| | | WBPaper00061527:swsn-2.2_209-ets-6 |
| | | WBPaper00061651:AFD_enriched |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:ASER_enriched |
| | | WBPaper00061651:AWC_OFF_enriched |
| | | WBPaper00061651:AWC_ON_enriched |
| | | WBPaper00061651:CEP_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:I4_enriched |
| | | WBPaper00061651:M2_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:RIR_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00062002:Day4-adult_secretome |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062193:hsf-1(RNAi)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064257:UNG-1_interacting |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_1 |
| | | WBPaper00025032:cluster_85 |
| | | WBPaper00025032:cluster_195 |
| | | WBPaper00025032:PAL-1_target_genes |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(23_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | Interaction (448) |
| | WBProcess | WBbiopr:00000017 |
| | | WBbiopr:00000120 |
| Map_info | Map | IV | Position | 5.3063 | Error | 0.001806 |
| | Well_ordered |
| | Positive | Positive_clone | C38H7 |
| | | | M117 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 3263 |
| | | | 3810 |
| | | Multi_point | 1262 |
| | | Pos_neg_data | 3264 |
| | | | 3265 |
| | | | 3266 |
| | | | 6749 |
| | | | 8178 |
| Reference (105) |
| Picture | WBPicture0000013084 |
| Remark | The ftt-1 gene was merged into par-5 following advice from J .Hodgkin (evidence from [Morton DG, Shakes DC, Kemphues K]). krb 02/03/04 |
| | Sequence connection from [Morton DG, Shakes DC, Kemphues K], 02/06/13 krb. |
| Method | Gene |
